KEGG   Ornithorhynchus anatinus (platypus): 100078508Help
Entry
100078508         CDS       T01045                                 

Gene name
PLCB1
Definition
phospholipase C, beta 1 (phosphoinositide-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:oaa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100078508 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100078508 (PLCB1)
   04310 Wnt signaling pathway
    100078508 (PLCB1)
   04020 Calcium signaling pathway
    100078508 (PLCB1)
   04070 Phosphatidylinositol signaling system
    100078508 (PLCB1)
   04022 cGMP - PKG signaling pathway
    100078508 (PLCB1)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    100078508 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100078508 (PLCB1)
   04062 Chemokine signaling pathway
    100078508 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    100078508 (PLCB1)
   04912 GnRH signaling pathway
    100078508 (PLCB1)
   04915 Estrogen signaling pathway
    100078508 (PLCB1)
   04921 Oxytocin signaling pathway
    100078508 (PLCB1)
   04918 Thyroid hormone synthesis
    100078508 (PLCB1)
   04919 Thyroid hormone signaling pathway
    100078508 (PLCB1)
   04916 Melanogenesis
    100078508 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100078508 (PLCB1)
   04270 Vascular smooth muscle contraction
    100078508 (PLCB1)
  Digestive system
   04970 Salivary secretion
    100078508 (PLCB1)
   04971 Gastric acid secretion
    100078508 (PLCB1)
   04972 Pancreatic secretion
    100078508 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100078508 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    100078508 (PLCB1)
   04725 Cholinergic synapse
    100078508 (PLCB1)
   04728 Dopaminergic synapse
    100078508 (PLCB1)
   04726 Serotonergic synapse
    100078508 (PLCB1)
   04720 Long-term potentiation
    100078508 (PLCB1)
   04730 Long-term depression
    100078508 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    100078508 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100078508 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    100078508 (PLCB1)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100078508 (PLCB1)
   05016 Huntington's disease
    100078508 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    100078508 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    100078508 (PLCB1)
   05143 African trypanosomiasis
    100078508 (PLCB1)
Enzymes [BR:oaa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100078508 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1233 aa AA seqDB search
MAGAQPGVHALQLKPVCVSDHLKKGTKFVKWDDDSTVVTPIILKTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEELAKEWADEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNICPRPEIDNIFSEFGAKSRPYL
TVDQMMEFINFKQRDPRLNEILYPPLKQEQVQQLIEKYEPNNNLAKKGQISVDGFMRYLS
GEENGVVPPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVTVLSGREECLWAQLHSSNIQGPSPISLQA
GEGASKAMMGAIPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVK
NKKKSHKSSEGSAKKKLSEQASNTYSDTSSVFEPSSPGTGEADIESDDDDDDEDDCKKSS
MDEGTAGSEAMATEEMSNLVNYIQPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPV
EFVEYNKMQLSRIYPKGTRVDSSNYMPQVFWNAGCQMVALNFQTVDLAMQINMGMYEYNG
KSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGL
PVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRLLPV
QAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRA
KQLAALTLEDEDEVKKEAEPGETPSETNNEPRPTPAENGVNHSASLAPKPPSQVVHSQPT
PGSVKAPAKSEDLIQSVLTEVEAQTIEELKQQKAFVKLQKKHYKEMKDLVKRHHKKTTDL
IKEHTTKYNEIQNDYLRRRAVLEKTAKRDSKKKSEASSPDHGSSTIEQDLAALDAEMTQK
LIELKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQSNQLKKLKEICEKE
KKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEDAQSKRHEKL
LEKHKEIRQQILDEKPKLQVELDQEYQDKFKRLPLEILEFVQEAMKGKISEDGEQISAPP
SLATDSGKLNHKPPQNEEGLEEDNPEKVFDTPL
NT seq 3702 nt NT seq  +upstreamnt  +downstreamnt
atggccggggcacagccgggagttcacgctctgcagctcaaacccgtctgcgtctcggac
cacctgaagaagggcaccaaattcgtcaaatgggatgatgattccaccgtggtgacccca
attattctgaagactgacccccagggatttttcttttactggacggatcaaaataaggag
acagagcttttggatctcagcctcgttaaggatgccagatgtgggaaacatgccaaagct
cctaaggatccgaaattgcgagaattgttggatgtggggaacataggacgcctggaacat
cgtatgataactgtagtgtatggtccagatttggttaacatctcccatttgaacttagtg
gcatttcaagaagaactagcgaaggaatgggcagatgaggtcttcagtttggcaacaaat
ttgctggcccaaaacatgtcaagggatgcatttctggaaaaagcctacaccaaactaaaa
ctgcaggtcactccagaagggcgaattcctctcaaaaacatctaccgcttgttttcagca
gaccgaaaacgagtagaaactgcattagaagcttgtagtcttccgtcttcgaggaatgat
tcgatacctcaagaagacttcacaccagaagtgtacagagtattcctaaacaatatttgc
cctcgaccagaaattgacaacatcttttcagagttcggtgcaaagagtagaccgtaccta
actgtggatcagatgatggagtttatcaattttaagcaacgggatcctcggctgaatgaa
atcctttacccacctttaaagcaggagcaagtccaacagctgattgagaagtacgaaccc
aacaataatttagcaaaaaaaggacagatatcagtggatggatttatgcgctatctgagt
ggagaagaaaatggagtggttccccctgagaaactggatttgaatgaagatatgtctcag
ccactctctcattatttcatcaattcttcccacaacacctacctcacagctggccagctg
gctgggaactcctcagtagagatgtatcgccaagtgctcttgtcaggttgccgttgcgta
gagctggactgttggaaagggcgaacggcagaagaggagccagttatcacgcatggattc
accatgacaacggaaatctcctttaaggaagtgacagtcttgagtggaagagaagaatgt
ttatgggcccagctccattcctccaatatacaaggaccctcacctatatccttgcaggct
ggggaaggagctagtaaagcaatgatgggggcgatccctaaacagcaagccaagatggca
gaatattgccgactaatatttggtgacgcgctgctcatggaaccactggaaaaataccca
cttgagtctggagttcctcttcccagccccatggatttaatgtataaaatactggtgaaa
aataaaaaaaaatctcacaagtcttccgaaggaagtgcgaaaaagaagctttccgagcaa
gcatccaatacgtacagcgacacgtccagtgtgtttgaaccctcgtctcctggaacggga
gaggctgatattgaaagtgatgatgatgacgatgatgaagatgactgtaaaaaatcatca
atggatgagggtactgctggaagcgaagccatggccactgaagaaatgtcaaacctggtg
aactatattcagccagtcaagtttgaatcctttgagacatcaaaaaagcgcaacaagagt
tttgaaatgtcatcttttgtggaaaccaaaggacttgaacaacttacaaagtctccagtg
gagtttgtagagtataacaagatgcagcttagccggatttatccaaagggaacgagagta
gattcttcaaactatatgcctcaagtcttctggaatgctggttgtcaaatggtggctctt
aactttcaaactgtagatctggctatgcaaatcaacatggggatgtatgaatataatgga
aaaagtgggtatagactaaagccagagttcatgagaagaccagacaagcattttgaccca
tttactgaaggtatcgtggatgggatagtagccaacaccttatctgttaagataatttct
ggccagtttctttctgataagaaagtcgggacttacgtagaagtagatatgtttggtttg
cccgtggacaccaggcgcaaagcgtttaagaccaagacatctcaaggaaatgctgtgaat
cctgtctgggaagaagaaccaattgttttcaagaaggtggtccttccttctctggcgtgc
ttaaggatagccgtttatgaagaaggaggtaaatttataggccaccggttactgcccgtc
caagcaattcgaccaggttatcactacatctgtctgaggaatgaaagaaatcaacctttg
atgctcccagctgtttttgtatacatagaagttaaagactatgtcccagatacttatgca
gatgttattgaagcattatccaatccaatccggtatgtgaatttgatggagcagagagct
aaacagctggcagcactcacactggaagatgaagatgaagtaaagaaagaggcggaacct
ggagaaactccatcggaaactaataatgagccgagaccaacgcccgcagaaaatggagtc
aatcacagcgcgtccctggcaccaaaaccaccttcacaggttgtccacagtcagccaaca
ccaggttctgtaaaagcacctgcaaaatcagaagatcttattcagagtgtccttacagaa
gtggaagcgcaaactattgaggaactgaaacaacagaaggcctttgttaaacttcagaag
aaacactacaaagaaatgaaggaccttgtcaagaggcaccataagaaaaccactgatctt
atcaaagagcacactacaaagtataatgaaatccagaatgattacttgaggcgcagagcc
gtcttggaaaaaacagcaaaaagagatagcaagaaaaaatctgaagcaagcagtcccgat
catggttcttcaacaattgaacaagaccttgctgctcttgatgcagaaatgacccagaag
ttaatagaattgaaggacaaacagcagcagcaacttctgaatctccgtcaggagcagtat
tacagtgaaaagtaccagaagcgagaacatattaagcttctgattcagaagctaacagat
gtggcagaggagtgccagagcaatcagttaaaaaagctaaaagagatttgtgaaaaagaa
aagaaagaattaaagaaaaaaatggataagaagagacaggagaagataactgaagccaaa
tcaaaggacaaaagtcaaatggaggaggagaagactgaaatgatccggtcatatattcaa
gaagtggtgcaatatattaagagattagaagatgcacaaagtaaacggcacgagaaactc
ttagagaaacacaaggagatccgtcagcaaatactggacgaaaaacctaagttgcaggtt
gaacttgatcaagaataccaagataaattcaaaagactccccctggaaattctggagttt
gttcaggaagcgatgaaaggaaagatcagtgaagatggagagcagatttctgcccctccc
tctctggccacagacagtggaaaactgaaccataagcctccacaaaacgaggagggattg
gaagaagacaatcctgaaaaagtgtttgatacgcccctctaa

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