KEGG   Ornithorhynchus anatinus (platypus): 100078989Help
Entry
100078989         CDS       T01045                                 

Gene name
SOS1
Definition
(RefSeq) SOS Ras/Rac guanine nucleotide exchange factor 1
  KO
K03099  son of sevenless
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
oaa01521  EGFR tyrosine kinase inhibitor resistance
oaa01522  Endocrine resistance
oaa04010  MAPK signaling pathway
oaa04012  ErbB signaling pathway
oaa04014  Ras signaling pathway
oaa04062  Chemokine signaling pathway
oaa04068  FoxO signaling pathway
oaa04072  Phospholipase D signaling pathway
oaa04150  mTOR signaling pathway
oaa04151  PI3K-Akt signaling pathway
oaa04510  Focal adhesion
oaa04540  Gap junction
oaa04630  Jak-STAT signaling pathway
oaa04650  Natural killer cell mediated cytotoxicity
oaa04660  T cell receptor signaling pathway
oaa04662  B cell receptor signaling pathway
oaa04664  Fc epsilon RI signaling pathway
oaa04714  Thermogenesis
oaa04722  Neurotrophin signaling pathway
oaa04810  Regulation of actin cytoskeleton
oaa04910  Insulin signaling pathway
oaa04912  GnRH signaling pathway
oaa04915  Estrogen signaling pathway
oaa04917  Prolactin signaling pathway
oaa04926  Relaxin signaling pathway
oaa05034  Alcoholism
oaa05160  Hepatitis C
oaa05165  Human papillomavirus infection
oaa05200  Pathways in cancer
oaa05205  Proteoglycans in cancer
oaa05206  MicroRNAs in cancer
oaa05210  Colorectal cancer
oaa05211  Renal cell carcinoma
oaa05213  Endometrial cancer
oaa05214  Glioma
oaa05215  Prostate cancer
oaa05220  Chronic myeloid leukemia
oaa05221  Acute myeloid leukemia
oaa05223  Non-small cell lung cancer
oaa05224  Breast cancer
oaa05225  Hepatocellular carcinoma
oaa05226  Gastric cancer
oaa05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:oaa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100078989 (SOS1)
   04010 MAPK signaling pathway
    100078989 (SOS1)
   04012 ErbB signaling pathway
    100078989 (SOS1)
   04630 Jak-STAT signaling pathway
    100078989 (SOS1)
   04068 FoxO signaling pathway
    100078989 (SOS1)
   04072 Phospholipase D signaling pathway
    100078989 (SOS1)
   04151 PI3K-Akt signaling pathway
    100078989 (SOS1)
   04150 mTOR signaling pathway
    100078989 (SOS1)
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    100078989 (SOS1)
   04540 Gap junction
    100078989 (SOS1)
  Cell motility
   04810 Regulation of actin cytoskeleton
    100078989 (SOS1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    100078989 (SOS1)
   04660 T cell receptor signaling pathway
    100078989 (SOS1)
   04662 B cell receptor signaling pathway
    100078989 (SOS1)
   04664 Fc epsilon RI signaling pathway
    100078989 (SOS1)
   04062 Chemokine signaling pathway
    100078989 (SOS1)
  Endocrine system
   04910 Insulin signaling pathway
    100078989 (SOS1)
   04912 GnRH signaling pathway
    100078989 (SOS1)
   04915 Estrogen signaling pathway
    100078989 (SOS1)
   04917 Prolactin signaling pathway
    100078989 (SOS1)
   04926 Relaxin signaling pathway
    100078989 (SOS1)
  Nervous system
   04722 Neurotrophin signaling pathway
    100078989 (SOS1)
  Environmental adaptation
   04714 Thermogenesis
    100078989 (SOS1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100078989 (SOS1)
   05231 Choline metabolism in cancer
    100078989 (SOS1)
   05206 MicroRNAs in cancer
    100078989 (SOS1)
   05205 Proteoglycans in cancer
    100078989 (SOS1)
   05210 Colorectal cancer
    100078989 (SOS1)
   05225 Hepatocellular carcinoma
    100078989 (SOS1)
   05226 Gastric cancer
    100078989 (SOS1)
   05214 Glioma
    100078989 (SOS1)
   05221 Acute myeloid leukemia
    100078989 (SOS1)
   05220 Chronic myeloid leukemia
    100078989 (SOS1)
   05211 Renal cell carcinoma
    100078989 (SOS1)
   05215 Prostate cancer
    100078989 (SOS1)
   05213 Endometrial cancer
    100078989 (SOS1)
   05224 Breast cancer
    100078989 (SOS1)
   05223 Non-small cell lung cancer
    100078989 (SOS1)
  Substance dependence
   05034 Alcoholism
    100078989 (SOS1)
  Infectious diseases
   05160 Hepatitis C
    100078989 (SOS1)
   05165 Human papillomavirus infection
    100078989 (SOS1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100078989 (SOS1)
   01522 Endocrine resistance
    100078989 (SOS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: RasGEF RasGEF_N RhoGEF Histone PH PH_10 IQ_SEC7_PH PH_13
Motif
Other DBs
NCBI-GeneID: 100078989
NCBI-ProteinID: XP_001509981
Ensembl: ENSOANG00000014976
Position
1
AA seq 1256 aa AA seqDB search
MARNTMELKANKEFCYFGSGLGNGSQEVQMQVHPTLLSTEDALQYVEELILQLLSMLCQA
QPRSVLDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKI
DHQVSVYIVAVLEYISADILKLVGNYVRNIRHFEITKQDIKVAMCADKVLMDMFHQDVED
ISVLSLTDEEPSSSGEQNYYDLVKAFMAEVRQYIRELNLIIKVFREPFASNSKLFSAHDV
ENIFSRIADIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAQDI
LRTGFHGHFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEE
KSEDEEDKECLKQAITALLNLQSSMERICSKSLAKRRLSESACRFYSQQMKGKQLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRLPG
ASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALI
SLQYRSTLERMLDVTMLQEEKEEQMRLPSSELYRFAEPDSEENIVFEENMQPKSGIPIIK
AGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIGRFEIPEPQPTEADRRA
MENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDADLLQRLEEFIGTVR
GKAMKKWVESITKIIQRKKQAQANGPSHNITFESSPPAIEWHISRPGHTETFDLLTLHPI
EIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVET
ENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILE
EAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEFLKRHGKELINFSKRR
KVAEITGEIQQYQNQPYCLRVESDIRRFFENLNPVGNSMEKEFPDYLFNKSLEIEPRNPK
PLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNS
PRTPLTPPPASAASSTTDACSVFDSDHSSPFHSSSDTIFIQVSLPHGPRSASVSSISFTR
STDETPVPPPVPPRRRPESAPAESSPSKMMSKHLDSPPAIPPRQPTSKGYSPRYSVPDAR
TPLSDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGRKSGFVDITLLPFKIQEL
NT seq 3771 nt NT seq  +upstreamnt  +downstreamnt
atggccaggaacactatggaactaaaggccaacaaagaattctgctactttggcagtggc
ttgggcaatggtagtcaagaagttcagatgcaagtccatccgacacttttatctactgag
gacgctctccagtatgttgaagagttaattctacagttgttaagtatgctgtgccaagcc
cagcctcgaagtgttttagatgtagaggagcgtgttcaaaaaagttttcctcatccaatc
gacaagtgggcgatagcggatgcccagtctgctattgaaaagaggaagcgaagaaaccca
ttatctctcccagtagaaaaaattcaccctttattaaaggaagtcctaggttataaaatt
gaccaccaagtttctgtttacatagtagcagtattagaatatatttctgcagatatttta
aagctggttggaaattacgtgcggaatataaggcattttgaaattacaaagcaagacatt
aaagtggcaatgtgtgctgataaggttttgatggatatgttccaccaagatgttgaagac
ataagtgtattatctttgacagatgaagagccttcttcctcaggggagcaaaattactat
gacctagtcaaagcatttatggctgaggttcgacagtatataagggaactcaatcttatc
attaaggtttttagagagccatttgcttccaattcaaagttattttcagctcatgatgta
gaaaatatatttagtcgaatagcagatattcatgagctgagtgtgaagttattgggccat
atcgaagacacagtggaaatgacagatgaaggcagcccccatccattagtaggcagttgc
tttgaagatttagcagaggaactggcattcgatccatatgaatcatacgctcaagatatt
ttacgaactggtttccatggtcattttcttagtcaattatccaagcccggggcagcactc
tatttgcagtcaataggagaaggtttcaaagaagctgttcagtatgttttgcccagatta
cttctggcccctgtctaccactgtctgcattactttgaacttctaaagcaattggaagaa
aagagtgaagatgaagaagacaaggaatgtttaaaacaagctataacagcccttcttaac
cttcagagtagtatggaaagaatatgttccaagagtcttgcgaaaaggaggctaagtgaa
tctgcatgtcgattttatagtcagcagatgaaggggaagcaactagcaattaagaaaatg
aacgagatccagaaaaacattgatggctgggagggaaaagacattggacaatgttgcaac
gaattcatcatggaaggcaccctcacccgtgtaggggccaaacacgagagacacatattt
ctcttcgacggcttgatgatttgctgcaaatccaaccacggccagccgaggcttcccggg
gccagcaacgcagagtaccgtctcaaagagaagttctttatgcggaaggtccaaattaac
gacaaggatgacactaacgaatacaagcacgccttcgagatcatcctaaaggacgagaac
agcgtgatattctcggctaagtcagcggaggaaaaaaacaactggatggccgcattgata
tctttacagtaccggagcaccttggagaggatgctcgatgtgaccatgctgcaggaggag
aaggaagagcagatgaggcttcccagttccgagctctataggtttgcggagccagactct
gaagagaacatcgtgttcgaagaaaacatgcagcccaaatcgggaatccccatcattaaa
gcgggaactgtaattaagcttatagagcgactgacgtaccacatgtacgcagatcccaat
tttgttcggacatttctcaccacatatagatctttctgcaaacctcaagagcttctaagt
cttcttataggaaggtttgaaattccagaacctcagccaaccgaagcggatcggagagcg
atggaaaatggagatcagccccttagcgcagaactcaaaagatttagaaaagaatacatt
cagcccgtgcagttgcgggtattaaatgtatgtcggcactgggtagagcaccacttctat
gatttcgaaagagatgcagatcttcttcagcggttggaagaatttattgggacagtccga
ggtaaagcgatgaaaaaatgggttgaatccatcacaaagataatccagcggaaaaagcag
gcccaagccaacggaccaagccacaacattacatttgaaagttcacctcctgccattgag
tggcatataagcagaccagggcacacagagacttttgacttgctcacactgcacccaata
gaaattgcccgacaactcactttacttgaatctgatctttaccgagctgttcagccatca
gagttagttggaagtgtgtggacaaaggaagataaagaaattaattctcctaacctgcta
aaaatgattaggcacaccactaatctcaccctgtggtttgaaaagtgtattgtagaaaca
gaaaatctggaggagagagtagctgtcgtaagtcgaataattgagatcttacaagtattt
caagaattgaacaattttaatggtgtgctagaagttgtaagtgccatgaactcatctcct
gtatatagactagaccacacatttgagcaaataccgagtcgccaaaagaaaattttagaa
gaagctcatgaattgagtgaagatcactataaaaaatatttggcaaaactcaggtctatt
aatccaccatgcgtgcctttctttgggatttatttgactaatatcttgaaaacagaagaa
ggcaatcccgagtttcttaaaaggcatgggaaagaactgataaactttagcaaaaggagg
aaagtggcagaaataacaggagagatccagcagtaccaaaaccaaccatattgcctacga
gtagaatctgacatcagaaggttctttgaaaatttgaatccagtgggaaatagcatggag
aaggaattcccagattaccttttcaacaagtccctggaaatagagccacgtaatcccaag
cctctaccaagatttcccaaaaaatacagctatcccctcaagtcacctggcgttcgtcca
tccaacccaagacccggtaccatgaggcaccctaccccgctgcagcaggagccaaggaaa
atcagctacagtcggatccccgaaagcgaaaccgagagcacagcgtccgcacccaattct
ccacgaaccccgttaacgccaccccctgcctctgctgcctccagcaccacagacgcttgc
agtgtgttcgattccgaccactcaagtccctttcactcaagcagcgataccatctttatc
caagtttccctgccccatggcccacgatccgcttcagtatcatccatcagctttaccagg
agcaccgatgaaacacccgtccctcccccggtccctccaaggaggcggccagagtccgcc
ccagcggaatcgtctccatccaagatgatgtctaagcatctggacagccctccggcgatc
cctccccggcaacccacgtcgaaaggctattccccacggtactcggtgccggacgcccgg
acccctctgtcggaccctcccgaaagccctcctttactgccgccccgagaacccgtgagg
accccggatgtcttctccagctcaccgctacacctgcagcctccccctctgggccgcaaa
agtggctttgttgacatcactctcctgccctttaaaatacaggaattataa

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