KEGG   Ornithorhynchus anatinus (platypus): 100086270Help
Entry
100086270         CDS       T01045                                 

Gene name
PIK3CB
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:oaa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100086270 (PIK3CB)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100086270 (PIK3CB)
   04015 Rap1 signaling pathway
    100086270 (PIK3CB)
   04012 ErbB signaling pathway
    100086270 (PIK3CB)
   04370 VEGF signaling pathway
    100086270 (PIK3CB)
   04630 Jak-STAT signaling pathway
    100086270 (PIK3CB)
   04668 TNF signaling pathway
    100086270 (PIK3CB)
   04066 HIF-1 signaling pathway
    100086270 (PIK3CB)
   04068 FoxO signaling pathway
    100086270 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    100086270 (PIK3CB)
   04024 cAMP signaling pathway
    100086270 (PIK3CB)
   04022 cGMP - PKG signaling pathway
    100086270 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    100086270 (PIK3CB)
   04152 AMPK signaling pathway
    100086270 (PIK3CB)
   04150 mTOR signaling pathway
    100086270 (PIK3CB)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100086270 (PIK3CB)
  Cell growth and death
   04210 Apoptosis
    100086270 (PIK3CB)
  Cellular commiunity
   04510 Focal adhesion
    100086270 (PIK3CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100086270 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    100086270 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    100086270 (PIK3CB)
   04660 T cell receptor signaling pathway
    100086270 (PIK3CB)
   04662 B cell receptor signaling pathway
    100086270 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    100086270 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    100086270 (PIK3CB)
   04670 Leukocyte transendothelial migration
    100086270 (PIK3CB)
   04062 Chemokine signaling pathway
    100086270 (PIK3CB)
  Endocrine system
   04910 Insulin signaling pathway
    100086270 (PIK3CB)
   04915 Estrogen signaling pathway
    100086270 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    100086270 (PIK3CB)
   04917 Prolactin signaling pathway
    100086270 (PIK3CB)
   04921 Oxytocin signaling pathway
    100086270 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    100086270 (PIK3CB)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100086270 (PIK3CB)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100086270 (PIK3CB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100086270 (PIK3CB)
  Nervous system
   04725 Cholinergic synapse
    100086270 (PIK3CB)
   04722 Neurotrophin signaling pathway
    100086270 (PIK3CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100086270 (PIK3CB)
  Development
   04380 Osteoclast differentiation
    100086270 (PIK3CB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100086270 (PIK3CB)
   05205 Proteoglycans in cancer
    100086270 (PIK3CB)
   05203 Viral carcinogenesis
    100086270 (PIK3CB)
   05210 Colorectal cancer
    100086270 (PIK3CB)
   05212 Pancreatic cancer
    100086270 (PIK3CB)
   05214 Glioma
    100086270 (PIK3CB)
   05221 Acute myeloid leukemia
    100086270 (PIK3CB)
   05220 Chronic myeloid leukemia
    100086270 (PIK3CB)
   05218 Melanoma
    100086270 (PIK3CB)
   05211 Renal cell carcinoma
    100086270 (PIK3CB)
   05215 Prostate cancer
    100086270 (PIK3CB)
   05213 Endometrial cancer
    100086270 (PIK3CB)
   05222 Small cell lung cancer
    100086270 (PIK3CB)
   05223 Non-small cell lung cancer
    100086270 (PIK3CB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100086270 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100086270 (PIK3CB)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100086270 (PIK3CB)
   05166 HTLV-I infection
    100086270 (PIK3CB)
   05162 Measles
    100086270 (PIK3CB)
   05164 Influenza A
    100086270 (PIK3CB)
   05161 Hepatitis B
    100086270 (PIK3CB)
   05160 Hepatitis C
    100086270 (PIK3CB)
   05169 Epstein-Barr virus infection
    100086270 (PIK3CB)
   05146 Amoebiasis
    100086270 (PIK3CB)
   05145 Toxoplasmosis
    100086270 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    100086270 (PIK3CB)
Enzymes [BR:oaa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100086270 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1041 aa AA seqDB search
MMPPAMADVLDIWAVDSQIAHDGPITVDFLLPTGVYVQLDVPREAPISSIKQMLWKQVHN
YPLFSLLTEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRNCDPGEKLDSK
IGVLIGKGLHEFDALEDPEVNDFRSKMRQISEAKIQSLVGLSWMDWLKHTYPPEQEASIL
ENIEDKLYGGHLVVAVHFENCQDVFSFQVSPNMNPLKLNELAIRKRLTIHGKEDEVNPYD
YVLQVSGKLEYVFGDDPLIQFQYIRKCVMNRTLPQLTLVECCNIKKMCEQEMIAIEAAIN
RNSSNLPLPLPPKKTRVVSSVWENSNPFQIVLVKGSKLNTEETVKVHVRAGLFHGTELLC
KPVVSSEIAGRNDHVWSETLEFDINICDLPRMARLCFAVYAVMDKAKTKKSTKAINPSKY
QTIRKAGKVHYPVAWVNTMVFDFKGQLKTGDIILHSWSSFPDELEEMLNPMGTVQTNPYT
ENATALHIKFPENKRQPYYYPPFDKIIEKAAEIASSDSGNMASRGGKKFHVVLKEIMERD
PLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSVKWNKLEDVAQLQALLQIWPKLPPRE
ALELLDFNYPDQYVREYAVGCLKQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERAL
ANRRIGQFLFWHLRSEVHIPAISVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSL
MKLNAVKLSRAKGKEAMHSCLKQNAYREALSDLQSPLNPCVILSELYIEKCKYMDSKMKP
LWIVYNNKVFGGDPVGIIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATG
DRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSC
AGYCVASYVLGIGDRHSDNIMVRKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFI
HVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLK
MAATENPFHCEKQSSNIAHYQ
NT seq 3126 nt NT seq  +upstreamnt  +downstreamnt
atgatgcctcctgctatggcagacgtccttgacatttgggcagtggattcccagatagcg
catgatggccccatcactgtggacttcctcttacctactggggtctatgtccagttggat
gtaccccgggaggctcccatttcttctattaaacagatgctgtggaaacaagtgcacaac
tatcctctgttcagtctccttacggaaattgactcttacatgtttgcttgtgtaaaccaa
actgccgtgtatgaagagctcgaagatgaaacccggaggctctgtgatgttcgacccttt
cttccagttctcaaattggtgacacgaaattgtgatccaggagaaaaattagactctaaa
attggtgtcctcataggaaaaggtcttcatgaatttgatgccttggaagatcctgaggta
aatgatttccgcagcaaaatgcggcagatcagtgaagcgaagatccaatctcttgtggga
ctgtcttggatggactggttaaagcacacgtatccaccagaacaagaggcttcaatcctg
gaaaatattgaagataaactttatggtgggcaccttgtagtggctgtccattttgaaaat
tgtcaggatgtgtttagtttccaagtatcccctaatatgaatcctctcaagctgaatgag
ctggcaatccgaaaacgtctgactatccacgggaaggaagatgaagtcaacccttatgac
tatgtattgcaagtcagtgggaagctggaatatgtgtttggtgatgatccattaattcag
ttccagtatatccgtaagtgtgtgatgaacaggacccttcctcagcttactctcgttgag
tgttgcaacatcaagaagatgtgtgaacaggaaatgattgccatagaagcagctataaat
cgaaattcatccaaccttcccctgcctctgccacccaaaaaaacacgagttgtttctagt
gtttgggaaaatagcaaccctttccaaattgtcctggttaaggggagtaaattgaacaca
gaagaaactgtcaaagtccatgtcagggctggcctctttcatggaactgagctcctttgt
aagcctgtagtaagctcagagatagctgggagaaatgatcacgtttggagcgaaacactg
gaatttgatatcaacatctgcgatttgccaagaatggctcggttgtgctttgctgtttac
gctgtgatggataaagcgaaaaccaaaaagtcgaccaaggcgattaatccctccaagtat
cagaccatcagaaaagctggaaaagtgcactaccctgtcgcatgggtgaataccatggta
tttgattttaaaggacagttgaaaactggagacatcatactgcacagctggtcatcattt
cctgatgaacttgaagaaatgttgaatccaatgggaacagttcaaacaaatccgtatact
gaaaatgcaacagcgctacatattaaattcccagaaaataaaaggcaaccatattactac
cctccctttgataagattattgagaaggcagctgagattgcaagcagtgacagtggcaat
atggcaagtcggggtggcaaaaagtttcacgttgttctcaaagaaatcatggaaagggac
cccctctctcaactgtgtgaaaatgaaatggatctcatttggactttgcgacaagactgc
agagagaatttcccgcaatcattgccaaaattactgctgtcggtaaagtggaataaactt
gaagatgttgctcagcttcaggctcttcttcagatatggcctaaacttcctcctagagaa
gccttggagttgctggattttaattacccagaccagtatgtgagagagtatgcagtggga
tgcttgaaacaaatgagcgatgaagagctctctcaatatcttctgcaacttgtgcaagtt
ctgaaatatgaaccttttctcgactgcgccctctccagatttctattagaaagagcacta
gctaatagaaggataggccaatttctattttggcatcttagatcagaagtgcacattcct
gccatttctgtgcaatttggtgtgatacttgaagcttattgcaggggcagtgttggacac
atgaaagtcctttccaaacaggttgaagcccttaataagctgaagaccttaaatagttta
atgaaactgaatgcagtcaagttaagccgagcaaaaggaaaggaggctatgcatagctgt
ttaaaacaaaatgcttaccgggaagcgctttctgatctccagtcacctctgaatccctgt
gtaatactctccgaactctatattgagaagtgtaaatacatggattctaaaatgaaaccc
ctgtggattgtgtacaacaacaaggtgtttggaggtgatccagtgggaatcatctttaaa
aacggggatgatctgcgacaagatatgttaacactccagatgctgcgcctgatggattta
ctttggaaagaagcaggtctggatctccgaatgctgccttatggttgtttagcaacagga
gaccgctctggtcttattgaagttgttagcacctctgaaacgattgcagatatccaacta
aatagcagtaatgttgctgctgctgctgccttcaacaaagatgctcttttaaactggctc
aaggaatacaattcgggagatgacttggatcgagccattgaggagtttaccctgtcctgt
gctggctactgtgtagcttcttatgttctaggaattggagatagacacagcgacaatatc
atggtccggaagaccggccagctcttccacattgattttggacatattcttggaaacttc
aagtctaaatttggaattaaaagggagcgagtgcctttcattcttacctatgatttcatt
catgtcattcaacaaggaaaaacaggaaacactgaaaaatttggccggttccgtcaatgc
tgcgaagatgcttacctaattcttcgaagacatgggaatcttttcatcactctttttgca
ctgatgttgactgcagggcttcctgaactcacctcggtcaaggatatacagtatcttaag
atggcagcaacagaaaatcctttccactgtgaaaagcaatcaagtaacatagctcactat
cagtaa

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