KEGG   Ornithorhynchus anatinus (platypus): 100086345
Entry
100086345         CDS       T01045                                 
Symbol
ADAM17
Name
(RefSeq) disintegrin and metalloproteinase domain-containing protein 17
  KO
K06059  disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
oaa04148  Efferocytosis
oaa04330  Notch signaling pathway
oaa05010  Alzheimer disease
oaa05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:oaa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    100086345 (ADAM17)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    100086345 (ADAM17)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    100086345 (ADAM17)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100086345 (ADAM17)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:oaa01002]
    100086345 (ADAM17)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:oaa04090]
    100086345 (ADAM17)
Enzymes [BR:oaa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.86  ADAM 17 endopeptidase
     100086345 (ADAM17)
Peptidases and inhibitors [BR:oaa01002]
 Metallo peptidases
  Family M12: astacin/adamalysin family
   100086345 (ADAM17)
CD molecules [BR:oaa04090]
 Proteins
  100086345 (ADAM17)
SSDB
Motif
Pfam: Reprolysin_2 Reprolysin_5 ADAM17_MPD Disintegrin Reprolysin_3 Reprolysin Reprolysin_4 Pep_M12B_propep
Other DBs
NCBI-GeneID: 100086345
NCBI-ProteinID: XP_028906446
Ensembl: ENSOANG00000013331
Position
X1:complement(34222..91650)
AA seq 843 aa
MRGRHRPSGAVSRPRLPVLVVLAVACSLPRVPARLPPQRPRPPHDKLDSMLSDYDILSLS
NIQQHSLRKRDLQAQSHRERLLSFSALHRHFKLYLTSNAERFSQNFKVLVVDGEKETEYP
VKRQDFFTGHVVGEHDSRVLAHIGDGDFTVRINTDGEEYNIEPLWRFINNTWDKRMLVYR
SEDIKNVSRLQSPKVCGYLNIEEEELLPKGLEDRELNRVHVHREKRAVPDPLKNTCKLLV
VADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKEPE
KVKPGEKHFNMAKSYPSEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLG
LAYVGSPRPNSHGGVCPKAYYSPSGKKHIYLNSGLTSTKNYGKTILTKEADLVTTHELGH
NFGAEHDPDIRTDCVPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKDSIFKTIETKAREC
FQERSNKVCGNSRVDEGEECDPGIMNLNSDPCCSSSCMLKTGVQCSDRNSPCCKNCQFET
AQKKCQEAINATCKGQSYCTGNSSECPPPGNAADDTVCLDLGKCKDGVCIPFCEREKNLQ
SCACNETDNSCKVCCRDLSGKCAPYVDADQKNLFLRKGKPCTVGFCDMNGKCEKRIQDVI
ERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYEENTKSL
SLFHPSNVEMLSSMDSASVRIVKPFPAPQPPGRPQSLPSTPAVSSAGAAAPRGDHQRMDT
IQEDPSTDSHVDEDAFEKDPFPNSSSAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKE
TEC
NT seq 2532 nt   +upstreamnt  +downstreamnt
atgcggggccgccaccggccgagcggggccgtgtcccgtccccgcctccccgtcttggtc
gtcctggcggtggcctgctcgctgccgcgggtcccggcccgcctgccgccccagcgaccc
cgacccccgcacgataaacttgattccatgctctcagactatgatatcctttctctgtca
aacatccagcagcactcattaagaaaaagagatctacaggcacagtcacatagagaaaga
ctcctgagtttttcagccttgcataggcactttaaattatacctaacatcaaatgctgaa
cgtttttcgcaaaatttcaaagtgttggtagtggatggagaaaaagagaccgaatatcct
gtaaaaaggcaagacttcttcaccggacacgtagttggtgagcatgattccagggttctg
gcacatataggtgatggtgacttcacagtaagaatcaacactgacggggaagaatataac
atagagccactttggagattcattaataatacttgggacaagagaatgttggtttatagg
tctgaagatatcaagaatgtttcacgtttgcaatctccaaaagtgtgtggttatttgaat
attgaggaggaagagctgctacctaaaggcctagaagaccgagagctaaatagagtgcat
gtgcatcgggagaagagagctgttccggatcctctgaagaatacatgcaagttgttggta
gttgcagaccatcgtttttacaagtacatgggtagaggggaagagagcacaactacaaat
tacttaatagagttaattgacagagttgatgacatctaccgtaatacgtcctgggataat
gcaggttttaaaggttatggaatccagatagaacagattcgcattttgaaggagcctgaa
aaggtaaaacctggtgaaaaacactttaatatggctaaaagttaccccagtgaagagaag
gatgcttgggatgtgaagatgttactggagcaattcagtttcgacatagccgaggaagct
tctaaagtctgcctcgctcatcttttcacgtaccaagactttgatatgggaactcttgga
ttagcttatgttggatctccgcggccaaacagtcacggaggtgtttgtccgaaggcttat
tatagcccatctggaaaaaaacacatttatctgaacagcggtttgacaagcacaaaaaat
tatggcaaaaccatccttacaaaggaagctgatttggtgactactcatgaattgggacac
aactttggagcagaacatgatcctgatattagaactgattgtgttccaaatgaagatcaa
ggaggaaaatatgtcatgtatccaatagctgtaagcggagatcatgagaacaataagatg
ttttcaaactgcagtaaggattccatcttcaagaccatcgagactaaagctcgggagtgt
ttccaagagcgcagcaacaaggtgtgtgggaactctagggtggatgagggagaagagtgt
gaccctggcatcatgaacctcaacagcgatccctgctgcagcagcagttgcatgctgaaa
acaggagtgcagtgcagtgatcggaacagtccttgttgtaagaactgtcaatttgagact
gcccagaaaaaatgccaggaggcgatcaatgcgacctgcaaaggacagtcttactgcact
gggaacagcagtgaatgtccccctcctggaaatgccgcagatgataccgtatgtttggac
ctggggaagtgcaaagatggtgtttgcattcctttctgtgagagagagaagaatctccaa
tcctgtgcatgcaacgaaaccgacaactcttgcaaagtctgctgccgggatctttctggt
aaatgtgctccttatgttgatgctgaccagaagaacctatttttgaggaaagggaaaccc
tgtactgtaggattctgtgacatgaatggtaaatgtgagaagcgaatccaggatgtgatt
gagcgattctgggattttattgaccaacttagcatcaatacatttgggaagttcttagcg
gacaacatagttggttcggtactggttttctccttgatattttggattcccttcagtatc
cttgtccactgtgtggacaagaaattggataaacaatatgaggagaacacaaaatcttta
tctttgttccaccctagtaacgtcgagatgctgagcagcatggattcggcgtcggttcgc
atcgtcaagccatttcctgcccctcagccccccgggaggcctcagtctctgccatccact
ccagccgtgtcctcggcaggggccgcggcgcccaggggagaccaccagaggatggacacc
attcaggaagaccccagtactgactctcacgtcgacgaagatgcttttgagaaggaccct
ttcccaaatagcagttcggctgcaaaatcttttgaggatctcacagaccatcctgtaact
agaagcgagaaggcagcctccttcaaattacagcgccagaatcgggtcgacagtaaagaa
acagagtgttag

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (38)   

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