KEGG T01045: 100090501

Ornithorhynchus anatinus (platypus): 100090501

Entry

100090501 CDS T01045

Gene name

FLT1

Definition

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Orthology

K05096

FMS-like tyrosine kinase 1 [EC:2.7.10.1]

Organism

oaa Ornithorhynchus anatinus (platypus)

Pathway

oaa04060	Cytokine-cytokine receptor interaction
oaa04066	HIF-1 signaling pathway
oaa04144	Endocytosis
oaa04151	PI3K-Akt signaling pathway
oaa04510	Focal adhesion
oaa05202	Transcriptional misregulation in cancer
oaa05323	Rheumatoid arthritis

Class

Environmental Information Processing; Signal transduction; HIF-1 signaling pathway [PATH:oaa04066]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:oaa04151]
Environmental Information Processing; Signaling molecules and interaction; Cytokine-cytokine receptor interaction [PATH:oaa04060]
Cellular Processes; Transport and catabolism; Endocytosis [PATH:oaa04144]
Cellular Processes; Cell communication; Focal adhesion [PATH:oaa04510]
Human Diseases; Cancers; Transcriptional misregulation in cancers [PATH:oaa05202]
Human Diseases; Immune diseases; Rheumatoid arthritis [PATH:oaa05323]

SSDB

Motif

Pfam:

Pkinase_Tyr I-set Ig_2 Pkinase Ig_3 ig V-set C1-set C2-set_2

Other DBs

NCBI-GI:

345319004

NCBI-GeneID:

100090501

Position

AA seq 1330 aa
MPSGDISVESMFEEKSVLRIDEGSSSGSKLKGPELNLKGTQHVLQAGQTLHLKCRGEAEH
SWSLPETVSKESKKLSVTTSVCGRNSKQFCSTLTLSRAQACHSGYFGCKYLSRPVSKKKK
VESTIYIFINDTGSPFIELNSAIPQVVYMAEGKEMVIPCRVSAPDIPVVLRKFPRETLIP
DGKTIIWDSRKGFIISKATYKFIGLLSCETTINGVLYSTKYLTHRPTNTIIDVQVDPSNP
IKLLRGHTLSLNCTVTAALNTRVQMTWSYPGKAHSRASITQRIDQSQYGTNVFYSFLVID
KVNHRDKGLYTCQVKSGPSVRSVNETVHVYEKPFITVKPRKQQVLETVAGKHSYRLSVKV
KAFPSPEIIWLKDGLPASERSTRYAARGSTLLIKDVAEEDAGDYTISLGIRQSSLKKNLT
IPLIVNVKPQIYEKAVSSFPDPNLHPLASRQVLTCTVYGVPRPTIRWIWHPCSQNHSKAR
SDSCSNTEGPFILTAESNIGNRIQSITQRMAVIEGKNKMASTLVIAEARSSGVYSCVAAN
KVGQVERNISFYVTDVPNGFHINLAKVPTEGEDLVLSCTVNKFLYRDITWILLRTVSNRT
MHHSISKQNAAVSGEFSVTLNLTIKNVSREDSGTYACRARNVYTGEEILQKKEVTIRELE
APFLLRDLVDQIVTINNSTSLDCRAGGVPEPQITWFKDNHEIQLEPGIVLGPGSGTLLID
RVTEEDEGLYRCTATNRRGSAGGSAYITVRGTPDKTRLELITLTCTCVAATLFWLLLTLF
IRKLKRPGSVAVKTDYLSLIVDPEELPLDEQCDRLPYDASKWEFARERLKLGKSLGRGAF
GKVVQAAAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGPHLNVVNLLGAC
TRHGGPLMVIVEYCKYGNLSHYLKSKRALFFLNKDAALQAAEPRKTKEEPEPGLRPGLGR
AASSESLASSGFQEERSLSEGEEEEEEGAFYKRPITMEDLISYSFQVARGMEFLSSKKCI
HRDLAARNILLSDNNVVKICDFGLARDIYKNPDYVRKGDARLPLKWMAPESIFDKVYSTQ
SDVWSYGVLLWEIFSLGASPYPGVQIDEDFCSRLKEGTRMRAPEFATAEIYQTMLDCWHR
NPEERPRFNELVEKLGDLLQASVEQDGKDYIPLSTALPAPAGSASRPPAPRQPYFQEDVS
APRSSSKSIDSIRYVNAFEFGRSQRLRTCAELSSRGRSMFEDYRASSSLVLASGELQRCP
WSGNKAKGPFVLGLNVSSWSKESGLGAPSARAPVARAQRRFTCDTSALDRMACCVPAGPA
PLGRGLPAPT

NT seq 3993 nt +upstreamnt +downstreamnt
atgccgagtggtgacatcagtgttgaaagcatgtttgaagaaaagagtgtcttgaggatt
gacgaaggatctagttcagggtcaaagttgaaaggtcccgaactgaatttgaaaggcaca
caacacgtcctgcaggcaggccagacgctccacctcaagtgcaggggagaagcagagcat
tcgtggtctttgcctgaaacagtcagcaaggagagtaaaaagctgagcgtgaccacatcc
gtctgcggaagaaacagcaagcagttctgcagcaccctgacactcagccgggcacaagcg
tgtcactcgggctactttggctgcaagtatttatcccgcccagtgtccaagaagaagaaa
gtcgaatccacaatctacatatttattaatgatacaggcagccctttcatagagctgaac
agtgccataccccaagtggtgtacatggctgaagggaaggagatggtcatcccctgtcgt
gtcagcgccccggacatccccgtggtgttaagaaagtttccacgagaaaccttgattcca
gatgggaagaccataatctgggatagccggaaaggctttataatatccaaggcgacgtat
aaattcataggactcctgagctgtgaaaccacgatcaacggggttctgtatagcacaaaa
tatctcacccaccgaccaaccaatacgattatcgacgttcaggtggacccctcgaatcca
atcaaattgctgcgaggtcacactctgtccctcaactgtactgtgacggctgccttgaat
accagagtccagatgacgtggagttacccgggcaaagcacacagcagggcctcgatcaca
caacgcatcgaccaaagtcagtatgggaccaatgtattctacagttttcttgtaattgat
aaagtgaaccaccgagacaaaggcctttatacgtgtcaagtgaagagcgggccgtccgtc
agatctgttaacgagacagtgcacgtctatgaaaaaccgttcatcaccgtgaaacctcga
aagcagcaggtgcttgagaccgtagctggcaagcactcctatcggctctctgtgaaagtg
aaggcgttcccctctccggagatcatatggctgaaggacggcctcccggcgtccgagagg
tccacccgctacgcggcccgaggctccaccctcctcatcaaagatgtggccgaagaggac
gcgggggattacacgatctcgctgggcatccggcagtccagtttaaaaaagaatctcacc
atccctctgatcgtgaacgtgaagccacagatctatgagaaagccgtgtcgtcctttcca
gatcccaatctccacccgctggccagcaggcaggtcctgacttgcacagtttatggcgtg
ccccggcctacaattaggtggatttggcatccctgtagccagaatcattccaaagcaagg
tcggattcctgctctaacaccgaggggcccttcatcctgactgctgaaagcaacattggg
aacaggatccaaagcattacccagcgcatggccgtcatagaagggaagaacaagatggcc
agcaccctggtgatagctgaggcgcgatcatctggagtctacagctgtgtggcggccaat
aaagtcgggcaggtggagagaaacattagcttttacgtcacagacgtccccaacggattt
cacattaacttggcgaaagtgcccaccgaaggggaagatctagtgttgtcctgcacagtc
aacaagttcctctacagagatatcacctggatcctgttgcggaccgtgagcaaccgaacg
atgcaccacagcatcagcaaacaaaacgcggccgtcagcggagagttctccgtcaccctg
aatctcaccatcaagaacgtttctcgggaagactctggcacctatgcctgcagagccagg
aacgtatatacgggggaggaaattctgcaaaagaaagaagtgaccattagagagctcgaa
gcgccattcctcctgagggaccttgtggatcagatcgtgaccatcaacaactccaccagt
ttagactgccgggccgggggggtccctgagccccaaataacctggtttaaagacaaccac
gagatccagctggagccaggcatcgtcctggggccaggaagcggcacgctgctgatcgac
cgggtgacagaggaggacgaagggctgtaccgttgcacggcgaccaaccgccggggatcc
gcggggggctctgcctacatcaccgtccgagggaccccggacaaaacccgcctggagctc
atcacgctgacctgcacctgtgtggccgccacgctcttctggctcctgttaacgcttttc
atccgcaagctgaaacggccgggttctgtggcagtgaagacagactacctgtctctcatc
gtggacccagaggaactgcccctggatgagcagtgtgacaggctcccttacgacgccagc
aaatgggagtttgcccgagaaagactcaagctgggcaagtctctgggccgaggggcgttc
gggaaggtggtccaagcagctgccttcggcatcaagaagtctcccacgtgtaggacggtg
gccgtgaaaatgctgaaagagggggcaacagccagcgagtacaaagccctgatgacagag
ctgaagatcctgactcacatcggcccccacctgaacgtggtgaacctgctgggagcctgt
actagacacggaggccccctgatggtgattgtggagtactgcaaatatggaaacttgtcc
cactacctcaagagcaaacgagccttgttcttcctcaacaaggatgccgccctgcaggcc
gccgagccccggaaaaccaaggaggagccggagccgggcctccggcccgggttgggaagg
gcagccagcagtgagagcttggcgagctccggcttccaggaagagcgaagtctgagtgaa
ggcgaggaggaggaggaggagggggcgttctacaagcggcccatcaccatggaagacctg
atttcatacagcttccaagtcgccaggggcatggagttcttgtcatccaaaaagtgcatc
caccgcgacctggccgcccgcaacatcctcctgtcggacaacaacgtggtgaagatctgt
gacttcggcctcgccagggacatctacaagaatcccgactacgtgcgcaaaggagacgcc
cggctccccctcaagtggatggccccagagtccatcttcgacaaggtctacagtacgcag
agcgacgtgtggtcctatggggtgctgctctgggagatcttctctttgggggcgtccccc
tacccaggggtgcagatcgatgaggatttctgcagccgcctaaaggaaggcaccaggatg
cgggcaccagagttcgccacagctgaaatttaccagactatgctggactgctggcatcgc
aaccctgaggagaggccccgctttaacgagctggtggaaaagctcggggacctgctgcaa
gccagtgtggaacaggatggtaaggattacatccccctgagcaccgcactgcctgccccc
gctgggtcggcatcccggcccccggccccgcgtcagccctatttccaagaagatgtttca
gctcccagatccagctcgaagagcatcgacagcatcagatacgttaatgctttcgaattt
ggccgatcccagcggctgaggacctgtgcagagctctcgtcccggggccgctccatgttt
gaggattaccgggccagcagcagcctggtcctggcctcaggggaacttcagcgctgcccc
tggagcggaaacaaagccaaaggacccttcgtcctgggcctgaacgtgagcagctggagc
aaggagtcgggcctgggggcccccagtgcccgtgcccccgttgcccgtgctcagcgccgc
ttcacgtgcgacacctcagcgctggacaggatggcgtgctgtgtgcccgcgggccctgcc
ccgctgggccggggccttcccgcccccacctaa

All links

Pathway (7)   
   KEGG PATHWAY (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (9)   
   Pfam (9)   
All databases (24)   

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