KEGG   Ovis aries (sheep): 443431Help
Entry
443431            CDS       T03117                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor isoform X1
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
oas  Ovis aries (sheep)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:oas00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    443431 (INSR)
   04015 Rap1 signaling pathway
    443431 (INSR)
   04010 MAPK signaling pathway
    443431 (INSR)
   04066 HIF-1 signaling pathway
    443431 (INSR)
   04068 FoxO signaling pathway
    443431 (INSR)
   04072 Phospholipase D signaling pathway
    443431 (INSR)
   04022 cGMP - PKG signaling pathway
    443431 (INSR)
   04151 PI3K-Akt signaling pathway
    443431 (INSR)
   04152 AMPK signaling pathway
    443431 (INSR)
   04150 mTOR signaling pathway
    443431 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    443431 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    443431 (INSR)
   04923 Regulation of lipolysis in adipocyte
    443431 (INSR)
   04913 Ovarian Steroidogenesis
    443431 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    443431 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    443431 (INSR)
   04213 Longevity regulating pathway - multiple species
    443431 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    443431 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    443431 (INSR)
   04931 Insulin resistance
    443431 (INSR)
Enzymes [BR:oas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     443431 (INSR)
Protein kinases [BR:oas01001]
 Tyrosine protein kinases
  InsR family [OT]
   443431 (INSR)
Enzyme-linked receptors [BR:oas01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   443431 (INSR)
Cytokine receptors [BR:oas04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   443431 (INSR)
CD molecules [BR:oas04090]
 Proteins
  443431 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Ensembl: 
UniProt: 
Position
5
AA seq 1382 aa AA seqDB search
MGAGGGSGAAAVLLLVVVAALLVGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL
QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTSEGLCCHSECL
GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKTSRRQG
CHQYVIHNNKCVPECPSGYTMNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC
TIINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
EIGNYSFYALDNQNLRQLWDWGKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPTRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE
RQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSEYEESAGECCSCPKTDSQIL
KELEESSFRKTFEDYLHNVVFIPRKSSSGPVAEDARPSRKRRALGDVGNVTAAVPTVLGF
PNSSSTSTPTSSEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYV
SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGEEELHLCV
SRRHYAVERGCRLRGLLPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIG
PLIFVFLFSVVIGSICLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR
EKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKG
FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA
AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV
RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN
CPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEME
FEDMESVPLDRSSHAQREEAGVRDGGSALGLKRNYDEHIPYTHMNGGKKNGRILTLPRSN
PS
NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt
atgggcgccgggggcgggagcggggcggcagccgtgctgctgctggtggtcgtcgccgcg
ctgctggtgggcgccgcgggccacctgtaccctggagaagtgtgccccggtatggatatc
cggaataatctcacccggctgcatgagctggccaactgctcggtcattgaaggacatttg
cagattctgttgatgttcaaaacgagacctgaggacttccgagacctcagtttccccaaa
ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag
gacttgttccccaacctcacggtcatccgaggctcgcgcctcttctttaattatgcactg
gtcatctttgagatggttcacctgaaggagcttggcctctacagcctgatgaacatcacc
cgggggtctgtccgcatcgagaagaacaatgaactctgctacctggccaccatcgactgg
tctcgaatcctggattccgtggaggataattacatcgtgctgaacaaagacgacaatgag
gagtgtggggacatttgtccaggcaccgccaagggcaagaccaactgccctgccactgtc
atcaacgggcagtttgtggagcggtgctggacacacagccactgccagaaagtgtgtccg
actatctgtaagtcacatggctgcacctctgagggtctctgctgccacagcgagtgcttg
ggcaactgctcagagcccgacgaccccaccaagtgcgtggcctgtcgcaacttctacctg
gacggcaggtgcgtggagacctgcccgcccccttactaccacttccaagactggcgctgc
gtgaacttcagcttctgccaggacctgcacaacaaatgcaagacctctcggaggcaaggc
tgccaccagtatgtcattcacaacaacaagtgcgtccccgagtgcccctctggctacacg
atgaattctagcaacttgatgtgtaccccttgcctgggcccctgtcccaaggtgtgccac
ctcctggaaggtgagaagaccatcgattcagtgacatctgcccaggagcttcgaggctgc
accatcatcaacggaagcttaatcatcaacattcgagggggcaacaacctggcagctgag
ctagaggccaaccttggactcattgaagaaatttcaggatatctgaaaatccgccggtcc
tatgccctggtgtcactttccttcttccggaagttacgtctgattcgaggggagaccttg
gaaattgggaactactctttctacgccttggacaaccagaacctaaggcagctatgggac
tggggcaaacacaacctcaccatcactcaggggaaactcttcttccactataaccccaaa
ctgtgcctgtcggaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggag
agaaatgacattgctctaaagaccaatggggaccaggcatcctgtgaaaatgaattactt
aaattttcttacattcggacatcttatgacaagatcttgctgaaatgggagccgtattgg
cctcctgacttccgagacctcctggggttcatgttgttctacaaagaggccccttaccag
aatgtgacagaatttgatgggcaggatgcgtgtggctccaacagctggacagtggtggat
attgacccgcctacaaggtccaacgaccccaagtcacagaaccatcctgggtggctgatg
cgtggtctcaagccctggacccagtatgccatctttgtcaagaccctggtcaccttttct
gatgaacgccgtacatacggagccaagagtgacatcatctatgtccagacagacgccact
aatccttccgtccccctggatcccatctcagtttctaattcctcgtcccagattattctg
aagtggaagcctccctccgaccccaatggcaatatcacacactacttggtgttctgggag
aggcaggcggaagatagtgagctgtatgaactggattattgcctcaaagggttgaagctg
ccctcccggacctggtctccaccgttcgagtcggaggggtcccagaagcacaaccagagt
gagtatgaggagtctgctggcgaatgctgctcctgcccgaagaccgactctcagatcctc
aaggagctggaggagtcctcgttcaggaaaacgtttgaagattacctgcacaacgtggtt
ttcatccccagaaaatcatcttcaggccctgttgccgaggacgctaggccttcgaggaaa
cgcagagcccttggtgacgtggggaatgtgacagcagccgtgcccactgttctggggttc
cccaatagctcctccaccagcacacccacaagctcagaggagcacagacccttcgagaaa
gtggtgaacaaggagtcgctggtcatctccggcctgcgtcactttactgggtatcgcatt
gagcttcaggcttgcaaccaagattcccccgaggagaggtgtagcgtggctgcctatgtc
agcgccaggaccatgcctgaagccaaggcagatgatattgtcggccccgtgacccatgaa
atcttcgagaacaacgtcgttcacttgatgtggcaggagcccaaggaacccaacggtctg
attgtgctgtatgaagtgagttaccgacgatatggcgaggaggagctgcacctctgcgtc
tcccgccggcattatgctgtggagcgcggctgccggctgcgcgggctgctgcctgggaat
tacagcgtgcgagttcgggctacctccctggcaggcaatgggtcttggacggaagccacc
tacttctacgtgacagactatttagacgtgccatcaaatattgcaaagatcatcatcggt
cccctcatctttgtctttctcttcagtgttgtgattggaagtatttgtctattcctgaga
aagaggcagccagatgggccactgggaccattgtatgcttcttcaaacccagagtacctc
agtgccagcgatgtgttcccatgctctgtgtatgtgccggacgagtgggaggtgcctcga
gagaagatcacgctcctgcgagaactgggtcaaggctccttcggcatggtgtacgagggc
aacgccagggacattgtcaagggtgaggcggagacccgcgtggcagtgaagacggtcaac
gagtcggccagcctgcgagagcggatcgagtttctcaacgaggcttcggtcatgaagggc
ttcacctgccaccatgtggtccgcctcctgggggtggtgtccaaaggccagccaacgctg
gtggtgatggagttgatggctcacggagacctgaagagttacctccgttccctgcggcct
gaggctgagaataaccccggccgccctccccctaccctgcaagaaatgattcagatggcg
gcagagatcgccgatgggatggcatacctgaacgctaagaagttcgtgcaccgggatctt
gcagcccggaactgcatggttgcccacgactttaccgtcaaaattggagacttcggaatg
acaagagacatctatgaaacggattactaccggaaagggggcaaaggtctgctccccgtg
cggtggatggcacctgaatccctcaaggacggagtcttcaccacctcttcagacatgtgg
tctttcggtgtggtcctttgggaaattaccagcttggctgaacagccttaccaaggtcta
tcaaatgagcaggtgctgaaatttgtcatggatggagggtacctggatcaacctgacaat
tgtccagagagagtcaccgacctgatgcggatgtgctggcagttcaaccccaagatgcgt
ccaaccttcctggagatcgtggacctgctcaaggatgacctgcaccccagctttcccgaa
gtgtccttcttccacagcgaggagaacaaggcgcccgagagcgaggagctggaaatggag
tttgaggacatggagagcgtgcccctggaccggtcctcgcacgcgcagagagaggaggcc
ggggtccgggacggagggtcggcgctggggctaaagcgaaactatgacgagcacatcccc
tatacccacatgaacgggggcaagaaaaacggacggattctgactttgccccggtcaaat
ccttcctaa

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