KEGG   Ovis aries (sheep): 443515
Entry
443515            CDS       T03117                                 
Symbol
IGF1R
Name
(RefSeq) insulin-like growth factor 1 receptor
  KO
K05087  insulin-like growth factor 1 receptor [EC:2.7.10.1]
Organism
oas  Ovis aries (sheep)
Pathway
oas01521  EGFR tyrosine kinase inhibitor resistance
oas01522  Endocrine resistance
oas04010  MAPK signaling pathway
oas04014  Ras signaling pathway
oas04015  Rap1 signaling pathway
oas04066  HIF-1 signaling pathway
oas04068  FoxO signaling pathway
oas04114  Oocyte meiosis
oas04140  Autophagy - animal
oas04144  Endocytosis
oas04150  mTOR signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04152  AMPK signaling pathway
oas04211  Longevity regulating pathway
oas04213  Longevity regulating pathway - multiple species
oas04510  Focal adhesion
oas04520  Adherens junction
oas04550  Signaling pathways regulating pluripotency of stem cells
oas04730  Long-term depression
oas04913  Ovarian steroidogenesis
oas04914  Progesterone-mediated oocyte maturation
oas05200  Pathways in cancer
oas05202  Transcriptional misregulation in cancer
oas05205  Proteoglycans in cancer
oas05214  Glioma
oas05215  Prostate cancer
oas05218  Melanoma
oas05224  Breast cancer
oas05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    443515 (IGF1R)
   04014 Ras signaling pathway
    443515 (IGF1R)
   04015 Rap1 signaling pathway
    443515 (IGF1R)
   04066 HIF-1 signaling pathway
    443515 (IGF1R)
   04068 FoxO signaling pathway
    443515 (IGF1R)
   04151 PI3K-Akt signaling pathway
    443515 (IGF1R)
   04152 AMPK signaling pathway
    443515 (IGF1R)
   04150 mTOR signaling pathway
    443515 (IGF1R)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    443515 (IGF1R)
   04140 Autophagy - animal
    443515 (IGF1R)
  09143 Cell growth and death
   04114 Oocyte meiosis
    443515 (IGF1R)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    443515 (IGF1R)
   04520 Adherens junction
    443515 (IGF1R)
   04550 Signaling pathways regulating pluripotency of stem cells
    443515 (IGF1R)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    443515 (IGF1R)
   04914 Progesterone-mediated oocyte maturation
    443515 (IGF1R)
  09156 Nervous system
   04730 Long-term depression
    443515 (IGF1R)
  09149 Aging
   04211 Longevity regulating pathway
    443515 (IGF1R)
   04213 Longevity regulating pathway - multiple species
    443515 (IGF1R)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    443515 (IGF1R)
   05202 Transcriptional misregulation in cancer
    443515 (IGF1R)
   05205 Proteoglycans in cancer
    443515 (IGF1R)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    443515 (IGF1R)
   05214 Glioma
    443515 (IGF1R)
   05218 Melanoma
    443515 (IGF1R)
   05215 Prostate cancer
    443515 (IGF1R)
   05224 Breast cancer
    443515 (IGF1R)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    443515 (IGF1R)
   01522 Endocrine resistance
    443515 (IGF1R)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oas01001]
    443515 (IGF1R)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:oas04090]
    443515 (IGF1R)
Enzymes [BR:oas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     443515 (IGF1R)
Protein kinases [BR:oas01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   443515 (IGF1R)
CD molecules [BR:oas04090]
 Proteins
  443515 (IGF1R)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like fn3 Kinase-like DUF4476
Other DBs
NCBI-GeneID: 443515
NCBI-ProteinID: XP_027812816
EnsemblRapid: ENSOARG00020005176
Position
18:7199205..7503235
AA seq 1367 aa
MKSSSGGGSPTSLWGLLFFAAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAASNNYIVGNKPPKECGD
LCPGTMEEKPLCEKTTINNEYNYRCWTTNRCQKMCPSACGKRACTETHECCHPECLGSCS
APDNATACVACRHYYYAGICVPSCPPNTYRFEGWRCVDRDFCANIPNAESSDSEGFVIHD
GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRQILGEEQLEGNYSF
YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
NNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSYLYRH
NYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
VFENFLHNAIFVPRPERKRREVMQIANTTMSSRSRNTTVLDTYNITDPEELETEYPFFES
RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
YTARIQATSLSGNGSWTEPVFFYVQAKTTYENFIHLMIALPIAVLLIVGGLVIMLYVFHR
KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG
VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME
LMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN
CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGV
VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL
EIISSVKDEMEAGFREVSFYYSEENKPPEPEELDLEPENMESVPLDPSASSASLPLPDRH
SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
NT seq 4104 nt   +upstreamnt  +downstreamnt
atgaagtctagctccggaggagggtccccgacctcgctgtggggactcctgtttttcgcc
gccgcgctctcgctctggcccacgagtggagaaatctgcgggccgggcatcgacatccgc
aacgactaccagcagctgaagcgcctggagaactgcacggtgatcgagggctacctccac
atcctgctcatttccaaggctgaggactaccgcagctaccgcttccccaagctcaccgtc
atcaccgagtacctgctgctgttccgcgtggccggcctcgagagcctgggcgacctcttc
cccaacctcacggtcatccgcggctggaagctcttctacaactacgccctggtcatcttc
gagatgaccaacctcaaggacatcgggctctacaacctgcggaatatcacccgtggggcc
atccggatcgagaagaacgccgacctctgctacctgtccacggtggactggtccctgatc
ctggacgccgcatccaacaactacattgtggggaacaagccccccaaggaatgcggggac
ctgtgcccggggacgatggaggagaagccgctgtgcgagaagacgaccatcaacaacgag
tacaactaccgctgctggaccacaaaccgctgccagaaaatgtgtcccagcgcgtgcggg
aagcgggcgtgcacggagacccacgagtgctgccaccccgagtgcctgggcagctgcagc
gcgcccgacaacgccacggcctgcgtggcctgccgccactactactacgccggcatctgc
gtgcccagctgcccgcccaacacctaccgcttcgagggctggcgctgcgtggaccgcgac
ttctgcgccaacatccccaacgccgagagcagcgactccgagggcttcgtcatccacgac
ggcgagtgcatgcaggagtgcccgtcgggcttcatccgcaacgggagccagagcatgtac
tgcatcccttgcgaaggcccttgtcccaaagtgtgtgaggaagaaaagaagacaaagacc
attgattctgtcacttctgctcagatgctccaaggatgcaccatcttcaaaggcaatctg
ctcatcaacatccgacgtggcaataacatcgcttcggaactggagaacttcatggggctc
atcgaggtggtgacgggctacgtgaagatccgccactcccacgccttggtctccttgtcc
ttcctgaagaacctgcgccagatcctaggggaggagcagctagaggggaactactccttc
tacgtccttgacaaccagaacctgcagcagctgtgggactgggaccaccgcaacctgacc
atcaaagctgggaaaatgtacttcgcgttcaatcccaagctgtgtgtctcggagatttac
cgcatggaggaagtgacggggactaaggggcgccagagcaaaggcgacataaacaccagg
aacaacggggagagagcctcctgtgaaagtgacgtcctgcatttcacctccaccaccacg
tcgaagaaccgaatcatcatcacctggcaccggtaccggccccccgactaccgggacctc
atcagcttcaccgtctactacaaggaagccccctttaaaaacgtcacggagtatgatggg
caggacgcctgcggctccaacagctggaacatggtggacgtggacctcccgcccaacaag
gacgtggagcctggcattttgctgcacgggctgaagccctggacgcagtacgccgtttac
gtgaaggccgtgaccctcaccatggtggagaacgaccacatccgtggggccaagagcgag
atcctgtacattcgcaccaatgcatcagttccttccatccccctggatgtcctctcggcc
tcaaactcctcttctcagctgatcgtgaagtggaacccgccctccctgcccaacggcaac
ctgagctactacatcgtgcgctggcagcgccagccccaggatagctacctgtaccggcac
aactactgctccaaagacaaaatccccatcaggaagtatgccgacggcaccatcgatgtc
gaggaggtgacggagaaccccaagaccgaggtgtgcggcggggagaaagggccgtgctgc
gcttgccccaaaaccgaagccgagaagcaggcggagaaggaggaggccgagtaccgcaag
gtcttcgagaacttcctgcacaacgccatcttcgtgcccagacccgaacggaagcggagg
gaggtcatgcagatcgccaacaccaccatgtccagccggagcaggaacaccacggtgctg
gacacctacaacatcacagacccggaagagctcgagactgagtaccctttcttcgagagc
agagtggacaacaaggagagaactgtcatctccaacctccggccttttactctgtaccga
atcgacatccacagctgtaaccacgaggctgagaagcttggctgcagcgcctctaacttt
gtctttgcaagaaccatgcctgcagaaggagcagatgacattcctgggccagtgacctgg
gagccaaggcctgagaactccatctttttaaaatggccagaacctgagaatcccaatgga
ttgatcctcatgtatgaaataaaatatggatcccaagtggaggatcagcgggaatgtgtg
tccagacaggagtacaggaagtatggaggagccaagctaaaccggctcaacccagggaac
tacacagcccggatccaggccacctctctctctgggaatgggtcatggacggagcctgtg
ttcttctatgttcaggccaagacgacatatgagaacttcatccacctgatgattgctctg
cccattgcggttctgttgatagtgggaggcttggttataatgctgtatgtcttccataga
aaaagaaataacagcaggctgggaaatggagtgctgtatgcctctgtgaacccggagtat
ttcagtgcagctgatgtgtacgtgcctgacgagtgggaggtggcccgggagaagatcacc
atgagccgcgagctgggccagggctccttcgggatggtctacgaaggcgtggccaagggc
gtggtcaaggatgagcccgagaccagggtggccattaagacggtgaacgaggccgccagc
atgcgcgagcggatcgagttcctcaacgaggcctcggtgatgaaggagttcaactgtcac
cacgtggtgcgcttgctgggcgtggtgtcccagggccagccgacgctggtcatcatggaa
ctgatgacccggggggacctcaagagttacctccggtctctgaggccagaaatggagaat
aatccagtcctagcacctcccagcctaagcaaaatgatccagatggctggcgagattgca
gatggcatggcatacctcaacgccaataagtttgtccacagagacctcgctgcccggaac
tgcatggtggccgaagatttcacagtcaaaatcggagattttgggatgacaagagacatc
tatgagacggactattaccggaagggggggaaggggctgctgcccgtccgctggatgtcc
cccgagtccctcaaggatggagtcttcaccactcactctgacgtctggtccttcggggtc
gtcctctgggagatcgccacgctggccgagcagccataccagggcctgtccaacgagcag
gtccttcgctttgtcatggagggcggccttctggacaagccggacaactgtcctgacatg
ctgtttgagctgatgcgcatgtgctggcagtacaaccccaagatgcggccctcgttcctg
gagatcatcagcagcgtcaaggacgagatggaggcgggcttccgggaggtctccttctac
tacagcgaggagaacaagccgcccgagccggaggagctggacctggagcccgagaacatg
gagagcgtgccgctggacccctcggcctcctctgcctccctgccgctgcccgacagacac
tcaggacacaaggctgagaacggcccgggcccgggcgtgctggtcctgcgggccagcttc
gacgagcggcagccgtacgcccacatgaacgggggccgcaagaatgagcgcgccctgccg
ctgccccagtcctcgacctgctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (29)   
   KEGG PATHWAY (29)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   ENSEMBLRAPID (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
Protein domain (7)   
   Pfam (7)   
All databases (55)   

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