KEGG   Orcinus orca (killer whale): 101272740
Entry
101272740         CDS       T05247                                 
Symbol
CACNA1C
Name
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1C isoform X7
  KO
K04850  voltage-dependent calcium channel L type alpha-1C
Organism
oor  Orcinus orca (killer whale)
Pathway
oor04010  MAPK signaling pathway
oor04020  Calcium signaling pathway
oor04022  cGMP-PKG signaling pathway
oor04024  cAMP signaling pathway
oor04260  Cardiac muscle contraction
oor04261  Adrenergic signaling in cardiomyocytes
oor04270  Vascular smooth muscle contraction
oor04713  Circadian entrainment
oor04720  Long-term potentiation
oor04723  Retrograde endocannabinoid signaling
oor04724  Glutamatergic synapse
oor04725  Cholinergic synapse
oor04726  Serotonergic synapse
oor04727  GABAergic synapse
oor04728  Dopaminergic synapse
oor04742  Taste transduction
oor04911  Insulin secretion
oor04912  GnRH signaling pathway
oor04921  Oxytocin signaling pathway
oor04924  Renin secretion
oor04925  Aldosterone synthesis and secretion
oor04927  Cortisol synthesis and secretion
oor04929  GnRH secretion
oor04930  Type II diabetes mellitus
oor04934  Cushing syndrome
oor04935  Growth hormone synthesis, secretion and action
oor05010  Alzheimer disease
oor05020  Prion disease
oor05022  Pathways of neurodegeneration - multiple diseases
oor05031  Amphetamine addiction
oor05207  Chemical carcinogenesis - receptor activation
oor05410  Hypertrophic cardiomyopathy
oor05412  Arrhythmogenic right ventricular cardiomyopathy
oor05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:oor00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101272740 (CACNA1C)
   04020 Calcium signaling pathway
    101272740 (CACNA1C)
   04024 cAMP signaling pathway
    101272740 (CACNA1C)
   04022 cGMP-PKG signaling pathway
    101272740 (CACNA1C)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    101272740 (CACNA1C)
   04929 GnRH secretion
    101272740 (CACNA1C)
   04912 GnRH signaling pathway
    101272740 (CACNA1C)
   04921 Oxytocin signaling pathway
    101272740 (CACNA1C)
   04935 Growth hormone synthesis, secretion and action
    101272740 (CACNA1C)
   04924 Renin secretion
    101272740 (CACNA1C)
   04925 Aldosterone synthesis and secretion
    101272740 (CACNA1C)
   04927 Cortisol synthesis and secretion
    101272740 (CACNA1C)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    101272740 (CACNA1C)
   04261 Adrenergic signaling in cardiomyocytes
    101272740 (CACNA1C)
   04270 Vascular smooth muscle contraction
    101272740 (CACNA1C)
  09156 Nervous system
   04724 Glutamatergic synapse
    101272740 (CACNA1C)
   04727 GABAergic synapse
    101272740 (CACNA1C)
   04725 Cholinergic synapse
    101272740 (CACNA1C)
   04728 Dopaminergic synapse
    101272740 (CACNA1C)
   04726 Serotonergic synapse
    101272740 (CACNA1C)
   04720 Long-term potentiation
    101272740 (CACNA1C)
   04723 Retrograde endocannabinoid signaling
    101272740 (CACNA1C)
  09157 Sensory system
   04742 Taste transduction
    101272740 (CACNA1C)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101272740 (CACNA1C)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    101272740 (CACNA1C)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101272740 (CACNA1C)
   05020 Prion disease
    101272740 (CACNA1C)
   05022 Pathways of neurodegeneration - multiple diseases
    101272740 (CACNA1C)
  09165 Substance dependence
   05031 Amphetamine addiction
    101272740 (CACNA1C)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    101272740 (CACNA1C)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    101272740 (CACNA1C)
   05414 Dilated cardiomyopathy
    101272740 (CACNA1C)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101272740 (CACNA1C)
   04934 Cushing syndrome
    101272740 (CACNA1C)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:oor04040]
    101272740 (CACNA1C)
Ion channels [BR:oor04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   101272740 (CACNA1C)
SSDB
Motif
Pfam: Ion_trans Ca_chan_IQ GPHH CAC1F_C PKD_channel
Other DBs
NCBI-GeneID: 101272740
NCBI-ProteinID: XP_012394726
Position
11:complement(1451965..1914259)
AA seq 2187 aa
MVNENTRMYIPEENHQGPSYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAAR
QAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTMATRPPRALLCLTLKNPIRRACISI
VEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVVA
YGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFR
VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYN
QEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCI
TMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGD
FQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGLDEEKPRNMSMPTSETESVNTENVA
GGDIEGESCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSSVFYWLVIFLVFLNTLT
IASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGI
LETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFL
FIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG
GPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLAR
TASPEKRQEVVEKPAVEETKEEKIELKSITADGESPPATKINMDDLQPNENEDKSSYPNL
ETTGDEEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSPSNRFRLQCHRIVNDSI
FTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFT
SIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLR
VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS
SKQTEAECKGNYVTYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL
YRSIDSHTEDKGPIYNYRVEISVFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCE
LDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHY
GQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGHFSDPWNVFDCLIVIGSVIDVILS
ETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPFMNAEENSRISITFFRLFRV
MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEI
NRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPGSSAEGEAPCGSSFAV
FYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIK
HLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIK
TEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK
RKEQGLVGKPPQRNALSLQAGLRTLHDLGPEIRRAISGDLTAEEELDKAMKEAVSAASED
DIFRRAGGLFGNHVGYYPSDSRSTFPQTFTTQRPLHISKAGTSQGDAESPSHEKLVDSTF
TPSSYSSMGSNANINNANNTALGRCPCPAGQPGAVSISTVEGRGPPLSPAVQVQGASWRL
SSQRCPSRDSLIAMVCQDEAPRDETCGLRMDEDAEYGSEPSLICTEMLSYQDDENRQLAP
PEEDRRDIHLSPKRGFLRSASLGRRASFHLECLKRQKNPGGDISQKTVLPLHLVHHQALA
VAGLSPLLQRSHPPGALPPPHATPPATPGPAWPLRPVPTLRLEGAESSDKLTSSFPSVHC
GPWAGEPTPCGASGGIRRARPVSLTVPSPAGPQGRPFHGSASSLVEAVLISEGLGQFAQD
PRFLKATTQELADACDMTIEEMESAADNILSGGARQSPNGTLLPCAHCRDPGPDREGGAE
DAAWAPSPEPRQGGEEPRDSRAFASSL
NT seq 6564 nt   +upstreamnt  +downstreamnt
atggtcaatgaaaacacgaggatgtacattccggaggaaaaccaccaaggtcccagctat
gggagcccgcgcccggctcacgccaacatgaatgccaacgcggccgcggggctggcacct
gagcacatccccacaccgggggccgccctgtcctggcaggcagccattgatgcggcccgg
caggccaagctgatgggcagcgctggcaacgccaccatctccacggtcagctccacgcag
cggaagcggcagcagtacgggaagcccaagaaacagggcagcacgatggccacgcgcccg
ccccgtgccctgctctgcctgaccctcaagaaccccatccggagggcatgcatcagcatc
gtggagtggaagccatttgaaatcattattttactgactatttttgccaactgtgtggcc
ttagcgatctacattcccttcccagaggacgactcgaacgccaccaactccaacctggaa
cgggtggagtatctctttctcatcatttttactgtggaagcatttttaaaagtcgtagcc
tacgggctgctctttcaccccaacgcttacctccgcaacggctggaacttgctggatttt
atcattgtggttgtcgggcttttcagtgcaatcttagagcaagccaccaaagccgacggg
gccaacgccctgggagggaagggggctggattcgacgtgaaggcgctcagggcgttccgc
gtgctgcggcctctgcggctggtgtccggggtcccgagtctccaggtggtcctgaactcc
atcatcaaggccatggtgccgctgctgcacatcgccctgctcgtgctcttcgtcattatc
atctacgccatcatcgggctggagctcttcatggggaagatgcacaagacctgctacaac
caggagggcatcgcagatgtcccagcagaagacgacccctccccctgtgccctggagacg
ggccacggccggcagtgccagaatggcacggtgtgcaagccgggctgggatgggcccaag
cacggcatcaccaacttcgacaactttgccttcgccatgctgaccgtgttccagtgcatc
accatggagggctggaccgacgtcctctactgggtcaatgatgccgtgggaagggactgg
ccctggatctattttgttacactaatcatcatagggtcgttttttgtacttaacttggtc
ctcggtgtccttagcggagagttttccaaagagagggagaaggccaaggcccggggcgac
ttccagaagctgcgggagaagcagcagctggaagaggacctgaagggctacctggactgg
atcacgcaggcggaggacatcgaccccgagaacgaggacgagggcttggacgaggagaaa
ccccgaaacatgagcatgcccaccagtgagaccgagtctgtcaacacggaaaacgtggct
ggaggcgacatcgagggagagagctgcggggccaggctggcccacaggatctccaagtcg
aagtttagccgctactggcgccgctggaatcggttctgcaggcggaagtgccgcgcggcc
gtgaagtcgagcgtcttctactggcttgtcatcttcctggttttcctcaacacgctcacc
atcgcctctgagcactacaaccagccccactggctcacggaagtccaagacacggccaac
aaggcgctgctggccctgttcacggcggagatgctgctcaagatgtacagcctggggctg
caggcctacttcgtgtccctgttcaaccgcttcgactgcttcatcgtgtgcggcggcatc
ctggagaccatcctggtggagaccaagatcatgtcgcccctgggcatctccgtgctgaga
tgcgtacgcctcctgcggatattcaagatcacgaggtactggaactccctgagcaacctg
gtggcgtccctgctgaactctgtgcgctccatcgcctccctgcttctgctgctgtttctt
ttcatcatcatcttctccctcctgggcatgcagctcttcggggggaagttcaactttgat
gagatgcagacccggaggagcacgttcgataacttcccccagtccctcctcaccgtgttt
cagatcctgaccggggaggactggaattcggtgatgtatgatgggatcatggcttatggc
ggcccctcttttccagggatgttagtctgtatttacttcatcatcctcttcatctgtgga
aattatatcctactgaatgtgttcttggccattgctgtggacaacctggctgacgccgag
agcctcacctctgcccagaaggaggaggaagaagagaaggagaggaagaagctggccagg
actgccagcccagagaagagacaagaggtggtggagaagccggccgtggaggagaccaag
gaggagaaaatcgagctgaaatccatcactgcggatggagagtccccccctgccaccaag
atcaacatggacgacctccagcccaacgagaatgaggacaagagttcctaccccaacctg
gaaaccacaggagacgaggaggaggagcctgagatgcccgtgggcccccgtccccgcccc
ctctctgagctgcacctgaaggagaaggcggtgcccatgccagaagccagcgccttcttc
atcttcagcccgagcaacaggttccgcctccagtgccaccgcatcgtcaacgactccatc
ttcaccaacctgatcctcttcttcatcttgctcagcagcatctccctggctgctgaggac
cccgtccagcacacctccttcaggaaccacattctgttttattttgacattgttttcact
accattttcaccattgaaattgctctgaagatcctaggcaacgcagactatgtcttcact
agtatctttacgttagaaattatcctcaagatgaccgcctacggggccttcctgcacaag
ggctccttctgccggaactacttcaacatcctggacctactggtggtcagcgtgtccctc
atctccttcggcatccagtccagcgccatcaatgtggtgaagatcttgcgggtcctgagg
gtgctgagacccctgagggccatcaacagggccaaggggctgaagcacgtggtgcagtgc
gtgttcgtggccatccgcaccatcgggaacatcgtgatcgtcaccacgctgctgcagttc
atgttcgcctgcatcggggtccagctcttcaagggcaagctctacacctgctcggacagt
tccaaacagacagaggccgaatgcaaggggaactacgtcacatacaaggacggggaggtg
gatcaccccatcatccagccccgcagctgggagaacagcaagtttgactttgacaatgtc
ctggcggctatgatggccctgttcaccgtctccacctttgaggggtggccagagctgctg
taccgctccatcgactcccacacggaggacaagggccccatttacaactaccgcgtggag
atctccgtcttcttcatcatctacatcatcatcatcgccttcttcatgatgaacatcttc
gtgggcttcgtcattgtcaccttccaggagcagggggagcaggagtacaagaactgcgag
ctggacaagaaccagcggcagtgcgtggagtacgcgctgaaggcccggcccctgcggagg
tacatccccaagaaccagcaccagtacaaggtgtggtacgtggtcaactccacctacttc
gagtacctgatgttcgtcctcatcctgctgaacaccatctgcctggccatgcagcactac
gggcagagctgcctgttcaaaatcgccatgaacattctcaacatgctgttcaccggcctc
ttcacggtggagatgattctgaagctcattgccttcaagcccaagggccactttagtgac
ccctggaatgtctttgactgcctcatcgtaattggcagcgtaattgacgtcattctcagt
gagacgaatcactatttctgtgatgcatggaacacgtttgacgccttgattgttgttggt
agcattgttgacatagccatcaccgaggtaaacccagctgaacatacccaatgctctccc
tttatgaacgcggaggagaactcccgcatctccatcaccttcttccgcctcttccgggtc
atgcgtctggtcaagctgctgagccgtggggagggcatccggacgctgctgtggacgttc
atcaagtccttccaggccctgccctacgtcgccctcctgatcgtgatgctgttctttatc
tacgccgtcatcgggatgcaggtgttcgggaaaatcgccctgaatgacacgacagagatc
aacaggaacaacaacttccagaccttcccccaggctgtgctgctgctcttcaggtgcgcc
accggggaggcgtggcaggacatcatgctggcctgcatgccgggcaagaagtgcgcgccc
gagtcggagccgggcagcagcgccgagggggaggcgccctgcggcagcagcttcgccgtc
ttctacttcatcagcttctacatgctctgcgcctttctgatcatcaacctcttcgtagct
gtcatcatggacaactttgactacctgacaagggactggtccattctgggtccccaccac
ctggacgaattcaagcgaatctgggcggagtatgatcctgaagccaagggtcgcatcaag
cacctggatgtggtgaccctgctccggaggattcagccgcccctgggctttgggaagctg
tgcccgcaccgcgtggcgtgcaaacgcctggtctccatgaacatgcccctgaacagcgac
gggacggtcatgttcaacgccaccctgtttgccctggtccggacggccctgaggatcaaa
acggaagggaacctggaacaggccaacgaggagctgcgggccatcatcaagaagatctgg
aagcggaccagcatgaagctgctggaccaggtggttccgcctgcgggagatgatgaggtc
acggtgggcaagttttacgctactttcctgatccaagagtatttccggaaattcaagaag
cgcaaagagcagggcctggtgggcaagcccccccagaggaacgccctgtccctgcaggct
ggtctgcgcaccctgcatgacctcgggcccgagatccgccgggccatctccggggacctg
accgccgaggaggagctggacaaggccatgaaggaggctgtgtccgcggcctcggaagat
gacatcttcaggagggccggtggcctgttcggcaaccacgtgggctactaccccagcgac
agccggagcaccttcccccagaccttcaccacccagcgccctctgcacatcagcaaggcg
ggcaccagccagggggacgcggagtcgccctcccacgagaaactggtggattccaccttc
acccccagcagctactcgtccatgggttccaacgccaacatcaacaacgccaacaacacc
gccctgggccgctgcccctgccctgccggccagcccggtgctgtcagcatcagcaccgtg
gagggccgtgggccccccttgtctcctgctgtccaggtgcagggggcctcgtggaggctc
agctcccagaggtgcccctcccgggacagcctgatagccatggtgtgtcaggacgaggcc
cctcgggatgagacttgtggcctgaggatggatgaggacgccgagtacggcagcgagccc
agcctgatctgcacggagatgctctcctaccaggacgatgagaatcggcagctggcgccc
cccgaggaggacaggagagacatccatctctctccgaagaggggcttcctgcgctctgcc
tccctaggtcgaagggcctccttccaccttgagtgtctgaagcgacagaagaatccaggg
ggagacatctctcagaagacagttctgcctctgcatctcgttcaccatcaggcgctggcg
gtggcgggcctgagccccctcctgcagagaagccatccccctggcgccctccccccgccg
catgcaacgccccctgccacgcctggcccggcctggcccctgcggcctgtgcccaccctg
cggctggagggggccgagtccagcgacaagctcaccagcagcttcccatccgtccactgc
ggcccctgggccggggagcccacgccctgcggggccagcggcggcatccggagggcccgg
cccgtgtccctcactgtgcccagcccggcagggccccagggccggcccttccacggcagc
gccagcagcctggtggaggcggtcttgatctcagaaggactggggcagtttgctcaggat
cccaggttcctcaaggccaccacccaggagctggccgacgcctgcgacatgaccatcgag
gagatggagagcgcggccgacaacatcctcagcgggggcgcccggcagagccccaacggt
accctgctcccgtgtgcacactgcagggacccggggccagaccgagaggggggcgcggag
gacgcggcctgggcgcccagccccgagccccgccagggcggagaggagccccgggacagc
agggccttcgccagcagcctgtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (34)   
   KEGG PATHWAY (34)   
Genome (1)   
   KEGG GENOME (1)   
Gene (42)   
   KEGG ORTHOLOGY (1)   
   RefGene (38)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (11)   
   RefSeq(pep) (11)   
DNA sequence (11)   
   RefSeq(nuc) (11)   
Protein domain (5)   
   Pfam (5)   
All databases (106)   

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