KEGG   Orcinus orca (killer whale): 101273162
Entry
101273162         CDS       T05247                                 
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X6
  KO
K08844  leucine-rich repeat kinase 2 [EC:2.7.11.1]
Organism
oor  Orcinus orca (killer whale)
Pathway
oor05012  Parkinson disease
oor05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:oor00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    101273162 (LRRK2)
   05022 Pathways of neurodegeneration - multiple diseases
    101273162 (LRRK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oor01001]
    101273162 (LRRK2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oor04131]
    101273162 (LRRK2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:oor04147]
    101273162 (LRRK2)
Enzymes [BR:oor01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101273162 (LRRK2)
Protein kinases [BR:oor01001]
 Serine/threonine kinases: TKL group
  LRRK family
   101273162 (LRRK2)
Membrane trafficking [BR:oor04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    101273162 (LRRK2)
Exosome [BR:oor04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   101273162 (LRRK2)
SSDB
Motif
Pfam: LRR_8 Roc Pkinase PK_Tyr_Ser-Thr COR LRR_4 Ras LRR_9 Arf T2SSE Ank_2 LRR_6 G-alpha AAA_22 AAA_16 nSTAND3 ABC_tran PduV-EutP MMR_HSR1 AAA_7 Kdo NACHT GTP_EFTU MobB TrwB_AAD_bind AAA_29 FtsK_SpoIIIE TniB ResIII NB-ARC AAA_23 SRP54
Other DBs
NCBI-GeneID: 101273162
NCBI-ProteinID: XP_033268242
Position
11:31434874..31594211
AA seq 2038 aa
MASGSCQDCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQDKN
VHVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGHDWEVLGVHQLIL
KMLTVHNASVNLSTVGLKALDLLLTSGKITLLILDEENDIFLLIFDAMRTFSANDEVQKL
GCKALHVLFERVSEEQLTEFVENKDYMILLSTLKHFKDEEEIVFHVLHCLYSLAIPCSNV
EVLMSGNVRCYNIVVEAMIAFPISEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
QQYSENAALQIAALSCLALLTETIFLNQDLEEKNENQENDDEEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDTM
AAVARKIITVMRSHETSVSVQLEALRAILHFIVPGIPEESREDTEYQHKLSMVKKQCFRN
DIHKLVLAALNRFIGNPGIQKCGLKVISSIAHFPDALEVLSLEDAIDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCIGTGHLLAKVLISSLQRFKDIGEIQMKGFQTILTVLELSV
SFSKLLVHHSFDSVIFHQLSSNIMEQKDQQFLNLCCKCFAKLAMDEELKSVMLERACDQN
NSIMVECLLLLGADANRAKEAASLICQVCEKASSPKVVELLLNSGSREQDVRKALTISIG
KGDSQIISLLLKRLALDLANNSICLGGFCMGKIEPSWLGPLFPDKTSNLRKETNIGSTLA
RMVLRYQMKSAVEEGTASGSSGTFSEEILDKFDEWTFIPESYVDSVFAQSDDLDSEGSEG
SFLVKKKSNSISVGEFYRDPALQRCSPNLQRHSNSLGPMFDHEDLLKRKRKILTSDDSLR
ASKFQSHMRHSESISSLSSEREYITSLDLSANELRDIDALSQKSCISGHLEHLEKLELHQ
NALTSFPQQLCETLKCLTHLDLQSNKFTSFPPYLLKMNCIANLDVSRNDIGPSVVLDRAV
RCSTLKQFNLSYNQLSFLPENLGDVVEKLEQLILEGNKISGIYSPLSLKELKILNLSKNH
ISSLSEDFLETCPKVESLSARMNFLAAMPFLPSSMTSLKLSQNRFTCVPEAILNLPHLRS
LDMSNNDIQYLPGPVHWRSLNLRELLFSHNQISILDLSEKACAWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKIKKSDLGMQGATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGCEEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPVEFPVIDQKRLLQLVKEH
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGCPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPTGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDNLMKKVEEGDLLVNPDQPRLTVPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRASYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGVRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGG
NT seq 6117 nt   +upstreamnt  +downstreamnt
atggccagtggcagctgccaagactgcgaggaggaggatgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagacgctggtccaaatcctg
gaggatatgctcgtgttcacctacgccgaccacgcctccaagttatttcaagacaaaaat
gtccacgtgcctctgttgatcgtcttggactcgtatatgagagtcgctagtgtgcagcag
gtgggttggtcacttttatgcaaattaatagaaatctgtccaaatacaatgcaaagctta
atgggtccccaggatattggacatgattgggaagtcctaggggttcaccaactgattctt
aaaatgctaacagttcataatgccagtgtcaacctgtcaacagttggattgaaggcctta
gatcttctcctaacttcaggtaaaatcactttgctgatactggatgaagaaaatgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgacgaagtccagaaactt
ggatgcaaagctttacatgtgctgtttgagagagtttcagaggagcaactgactgaattt
gttgagaataaagattatatgatattgctaagtacattaaaacattttaaagatgaagag
gaaattgtgtttcatgtactgcactgtttatattccctagcaattccttgcagtaatgtt
gaagtcctcatgagtggcaatgtcaggtgttataatattgtggtagaagccatgatagca
ttccctatcagtgaaaaaatccaagaagtgagttgctgcttgctccataggcttacatta
ggtaatttttttaatattctggtattaaacgaggtgcatgagtttgtggtgaaagctgtg
cagcagtattcagagaatgcagcattacagattgcagcactcagctgtttagctctcctc
actgagaccattttcttaaatcaagacttagaggaaaagaatgagaatcaggagaatgat
gatgaagaagaagataaattgttttggctggaagcctgctacaaagcattaacgtggcat
agaaagaacaagcatgtgcaggaggctgcatgttgggccctgaataatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccagttcccagctcacagggaa
gtgatgctctcgatgctgatgcattcttcatcaaaagaagtcttccaggcatctgcaaat
gcattgtcgactctgttagaacaaaatgttaatttcagaaagatcctgttatcaaaagga
atatatctgaatgtattggagttaatgcagaagcatatacattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatctttttgaaggaagtaacacttccctggatacaatg
gcagcagtggcccgcaaaataataacagttatgagaagtcatgagacgtcagtatcagtg
cagctggaggcacttcgagctattttacattttatagttccaggcatcccagaagaatcc
agggaagatactgaatatcagcataagctaagtatggttaaaaaacagtgtttcaggaat
gatattcacaaattggtcctagcggctttgaacaggttcattggaaatcctgggattcag
aaatgtggattaaaagtaatttcttctatagcacattttcctgatgcattagaggtgtta
tccctggaagatgctattgattcggtgcttcacacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatgtttgattacaaagaagaatttatgc
ataggcactgggcatctgctggcaaaagttctgatttccagcctacaacgatttaaggat
attggtgaaatacagatgaaaggatttcagacaatcttgacggtactggaattgtcagtg
tctttttccaagctgctggtgcatcattcctttgattcagtaatattccatcagttgtcc
tccaacatcatggagcaaaaggatcaacagtttctaaatctttgttgcaagtgctttgca
aaattggccatggatgaagagttaaaaagtgtgatgctagagagagcatgtgatcagaat
aacagcatcatggtcgaatgcttgcttctgttgggagcggatgccaatcgagcaaaagaa
gcagcttctttaatttgtcaggtatgtgagaaagcgagcagtcccaaagtggtagaactg
ttactgaatagtggatcccgtgagcaggatgtacggaaagctctaacaatcagcattggg
aaaggcgacagccaaatcatcagcttactcttaaagaggcttgccctggatctggccaat
aatagcatctgccttggaggattttgtatgggaaaaattgaaccttcttggcttggtcct
ctatttccagataagacatctaatttaagaaaagagacaaatataggatccaccctagcg
agaatggtgctcagatatcagatgaaaagtgctgtggaagaaggaacagcctcaggcagc
agtgggactttttctgaagaaatacttgataaatttgatgaatggaccttcattcctgag
tcttatgttgacagtgtatttgctcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaaagaaatcaaattcaattagcgtaggagaattttaccgagatcct
gccttgcagcgttgctcaccaaatttgcaaagacattccaattcattgggacccatgttt
gatcatgaagatttactgaagagaaaaagaaaaatattgacttcagatgattcactcaga
gcatcaaaattccaatcacatatgaggcattcagagagcatttcttccctgtcttctgag
agagaatatattacatctttagacctttcagcaaatgaactaagagatattgatgccctg
agccagaaatcctgtataagtggtcatttggagcatcttgaaaagctggaacttcaccag
aatgcactcacgagctttccacaacaactatgtgaaactctgaagtgtttgacacatttg
gacctgcaaagtaataaatttacatcatttcccccttacttgttgaaaatgaattgtatt
gccaaccttgacgtctctcgaaacgacattggaccctcagtagttttggatcgggctgtg
aggtgctcaaccttgaaacagtttaacctgtcctacaatcagctatcttttcttcctgag
aatctcggtgatgtggtagagaaacttgaacagctcattttagaaggaaataaaatatca
ggaatatattcccctttgagcctgaaggaactgaagattttaaaccttagtaaaaaccac
atttcatctctatcagaggactttcttgagacttgtcctaaagtggagagtttaagtgcc
agaatgaattttcttgctgctatgccttttttgccttcttccatgacaagcctaaaatta
tctcaaaacagatttacatgtgttccagaagcaattttaaatcttccacacctgcggtcc
ttagatatgagcaacaatgatattcaatatctaccaggtcctgtgcactggagatctttg
aacttaagggaactcttgtttagtcataatcagatcagtatcttggacttgagtgaaaaa
gcatgtgcatggtctagagtagagaaactacatctttctcataataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctcttgatgttagttacaacttggag
ctgagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcatcttaattttgattttaaacacataggatgtaaagccaaagacatcataagg
tttcttcaacagcggttaaaaaaagctgtgccctataaccgaatgaaacttatgattgtg
ggaaataccgggagtggtaagaccaccttgttgcagcaattaatgaaaatcaagaaatca
gatcttgggatgcaaggtgccacagttggcatagacgtgaaagactggcccatccaaata
agaggcaaagggaagaaagaccttattctaaatgtgtgggattttgcaggttgtgaggaa
ttctacagcactcacccccactttatgacccaacgagccctgtatcttgctgtctatgac
ctcagcaaagggcaagctgaagttgatgccatgaagccttggctcttcaatataaaggct
cgtgcttcttcgtcccctgtgattcttgttgggacacatttggatgtttctgatgagaag
cagcgcaaagcctgtatcagtaaaatcaccaaggagctcttgaacaaacgagggtttcct
gcaatacgggattaccactttgtaaatgccactgaggaatccgatgctttggcaaaactt
cggaaaaccatcataaatgagagcctcaatttcaagatccgagatcagcctgttgttggg
cagctgattccagactgctatgtagaacttgagaaaatcattttatcagagcgtaaaaat
gtgccagttgaatttcctgtaattgaccagaaacgattattacaacttgtgaaagaacat
cagctgcagttagatgaaaatgagcttcctcatgcagttcacttcctaaatgaatcaggg
gtcctccttcattttcaagacccagccttgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcccagattttgacagtgaaagtggagggctgtccaaag
catcctaagggaattatttcacgtagagatgtggaaaaatttctttcaaagaaaaagaga
tttccaaagaactacatgtcacagtactttaaactcttagaaaaattccagattgccttg
ccaacaggagaagaatatttgctggttccaagcagtttgtcggaccacagacctgtaata
gagcttccccattgtgagaactctgaaattatcattcgactgtatgaaatgccttatttt
ccaatgggcttttggtcgagattaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttattgcttggtaggatctgaagtcttagataatcacccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttttgggccaagtt
gtggaccacattgactctctcatggaagagtggtttccagggttattggagattgatatt
tgtggtgaaggagaaactctgttgaagaagtgggcattatatagttttaatgatggtgaa
gaacatcagaaaatcttacttgacaacttgatgaagaaagtagaagaaggagacctccta
gtgaatccagaccaaccaaggctcaccgttccaatatctcagattgctcctgacttgatt
ttggctgacctgcctagaaatattatgttgaataatgatgaattggaatttgaacaagct
ccagagtttcttttaggtgacggcagttttggatctgtttatcgagcgtcctatgaagga
gaagaagtggctgtgaagatttttaataaacatacatcacttagactgttaagacaagag
ctggtggtgctttgccacctccaccatcccagcttaatatctttgctggcagctggggtt
cgtcctcgaatgttggtgatggagttagcctccaagggttccctggatcgcctgcttcaa
caagacaaagccagtctcaccagaacgctgcagcacaggattgcactacatgtggctgat
ggtctgagatacctccactcagccatgattatataccgtgacttgaagccccacaacgtg
ttgcttttcaccctgtatcccaatgccgccatcattgccaagattgcggactatgggatt
gctcagtactgctgtagaatggggataaaaacgtcagagggcacaccaggtgggtga

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   RefGene (27)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (6)   
   RefSeq(pep) (6)   
DNA sequence (7)   
   RefSeq(nuc) (7)   
Protein domain (32)   
   Pfam (32)   
All databases (85)   

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