KEGG   PATHWAY: pae00860Help
Entry
pae00860                    Pathway                                

Name
Porphyrin and chlorophyll metabolism - Pseudomonas aeruginosa PAO1
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Porphyrin and chlorophyll metabolism
pae00860

All organismsOrtholog table
Module
Cobalamin biosynthesis, cobinamide => cobalamin [PATH:pae00860]
Other DBs
BSID: 
GO: 
Organism
Pseudomonas aeruginosa PAO1 [GN:pae]
Gene
PA3134  
gltX; glutamyl-tRNA synthetase [KO:K01885] [EC:6.1.1.17]
PA4666  
hemA; glutamyl-tRNA reductase [KO:K02492] [EC:1.2.1.70]
PA3977  
hemL; glutamate-1-semialdehyde aminotransferase [KO:K01845] [EC:5.4.3.8]
PA4088  
aminotransferase; K01845 glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8] [KO:K01845] [EC:5.4.3.8]
PA5523  
aminotransferase; K01845 glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8] [KO:K01845] [EC:5.4.3.8]
PA5243  
hemB; delta-aminolevulinic acid dehydratase [KO:K01698] [EC:4.2.1.24]
PA5260  
hemC; porphobilinogen deaminase [KO:K01749] [EC:2.5.1.61]
PA5259  
hemD; uroporphyrinogen-III synthase [KO:K01719] [EC:4.2.1.75]
PA5258  
hypothetical protein; K02496 uroporphyrin-III C-methyltransferase [EC:2.1.1.107] [KO:K02496] [EC:2.1.1.107]
PA2611  
cysG; siroheme synthase [KO:K02302] [EC:4.99.1.4 1.3.1.76 2.1.1.107]
PA1778  
cobA; uroporphyrin-III C-methyltransferase [KO:K02303] [EC:2.1.1.107]
PA0510  
uroporphyrin-III C-methyltransferase; K02303 uroporphyrin-III C-methyltransferase [EC:2.1.1.107] [KO:K02303] [EC:2.1.1.107]
PA5034  
hemE; uroporphyrinogen decarboxylase [KO:K01599] [EC:4.1.1.37]
PA0024  
hemF; coproporphyrinogen III oxidase [KO:K00228] [EC:1.3.3.3]
PA0386  
coproporphyrinogen III oxidase; K02495 oxygen-independent coproporphyrinogen III oxidase [EC:1.3.99.22] [KO:K02495] [EC:1.3.99.22]
PA1546  
hemN; coproporphyrinogen III oxidase [KO:K02495] [EC:1.3.99.22]
PA4655  
hemH; ferrochelatase [KO:K01772] [EC:4.99.1.1]
PA0113  
protoheme IX farnesyltransferase; K02301 protoheme IX farnesyltransferase [EC:2.5.1.-] [KO:K02301] [EC:2.5.1.-]
PA1321  
cyoE; protoheme IX farnesyltransferase [KO:K02301] [EC:2.5.1.-]
PA0112  
hypothetical protein; K02259 cytochrome c oxidase assembly protein subunit 15 [KO:K02259]
PA2904  
cobI; precorrin-2 C(20)-methyltransferase [KO:K03394] [EC:2.1.1.151 2.1.1.130]
PA2906  
oxidoreductase; K02229 precorrin-3B synthase [EC:1.14.13.83] [KO:K02229] [EC:1.14.13.83]
PA2947  
hypothetical protein; K02189 cobalt-precorrin 5A hydrolase [EC:3.7.1.12] [KO:K02189] [EC:3.7.1.12]
PA2903  
cobJ; precorrin-3 methylase CobJ [KO:K13541] [EC:2.1.1.131 3.7.1.12]
PA2948  
cobM; precorrin-3 methylase [KO:K05936] [EC:2.1.1.271 2.1.1.133]
PA2909  
cobalt-precorrin-6x reductase; K05895 precorrin-6A/cobalt-precorrin-6A reductase [EC:1.3.1.54 1.3.1.106] [KO:K05895] [EC:1.3.1.106 1.3.1.54]
PA2908  
cbiD; cobalt-precorrin-6A synthase [KO:K02188] [EC:2.1.1.195]
PA2907  
cobL; precorrin-6y-dependent methyltransferase CobL [KO:K00595] [EC:2.1.1.132]
PA2905  
cobH; precorrin-8X methylmutase [KO:K06042] [EC:5.4.99.60 5.4.99.61]
PA1273  
cobB; cobyrinic acid a,c-diamide synthase [KO:K02224] [EC:6.3.5.11 6.3.5.9]
PA1923  
cobaltochelatase subunit CobN; K02230 cobaltochelatase CobN [EC:6.6.1.2] [KO:K02230] [EC:6.6.1.2]
PA2944  
cobN; cobaltochelatase subunit CobN [KO:K02230] [EC:6.6.1.2]
PA1272  
cobO; cob(I)yrinic acid a,c-diamide adenosyltransferase [KO:K00798] [EC:2.5.1.17]
PA4399  
hypothetical protein; K00798 cob(I)alamin adenosyltransferase [EC:2.5.1.17] [KO:K00798] [EC:2.5.1.17]
PA1277  
cobQ; cobyric acid synthase [KO:K02232] [EC:6.3.5.10]
PA1275  
cobD; cobalamin biosynthesis protein [KO:K02227] [EC:6.3.1.10]
PA1276  
cobC; threonine-phosphate decarboxylase [KO:K02225]
PA1278  
cobP; adenosylcobinamide kinase [KO:K02231] [EC:2.7.7.62 2.7.1.156]
PA1281  
cobV; cobalamin synthase [KO:K02233] [EC:2.7.8.26]
PA1279  
cobU; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [KO:K00768] [EC:2.4.2.21]
PA1280  
hypothetical protein; K02226 alpha-ribazole phosphatase [EC:3.1.3.73] [KO:K02226] [EC:3.1.3.73]
PA2942  
magnesium chelatase; K03405 magnesium chelatase subunit I [EC:6.6.1.1] [KO:K03405] [EC:6.6.1.1]
Compound
C00025  
L-Glutamate
C00032  
Heme
C00037  
Glycine
C00188  
L-Threonine
C00194  
Cobamide coenzyme
C00430  
5-Aminolevulinate
C00486  
Bilirubin
C00500  
Biliverdin
C00524  
Cytochrome c
C00541  
Cob(II)alamin
C00748  
Siroheme
C00853  
Cob(I)alamin
C00931  
Porphobilinogen
C00992  
Aquacob(III)alamin
C01024  
Hydroxymethylbilane
C01051  
Uroporphyrinogen III
C01079  
Protoporphyrinogen IX
C01708  
Hemoglobin
C02139  
Chlorophyllide
C02191  
Protoporphyrin
C02463  
Precorrin 2
C02469  
Uroporphyrin III
C02800  
4,5-Dioxopentanoate
C02823  
Cyanocobalamin
C02880  
Protochlorophyllide
C02987  
L-Glutamyl-tRNA(Glu)
C03029  
Transferrin[Fe(II)]2
C03114  
Dimethylbenzimidazole
C03179  
Transferrin[Fe(III)]2
C03194  
(R)-1-Aminopropan-2-ol
C03263  
Coproporphyrinogen III
C03516  
Magnesium protoporphyrin
C03741  
(S)-4-Amino-5-oxopentanoate
C04122  
D-1-Aminopropan-2-ol O-phosphate
C04536  
Magnesium protoporphyrin monomethyl ester
C04778  
N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole
C05306  
Chlorophyll a
C05307  
Chlorophyll b
C05766  
Uroporphyrinogen I
C05767  
Uroporphyrin I
C05768  
Coproporphyrinogen I
C05769  
Coproporphyrin I
C05770  
Coproporphyrin III
C05772  
Precorrin 3A
C05773  
Cobyrinate
C05774  
Cobinamide
C05775  
alpha-Ribazole
C05777  
Coenzyme F430
C05778  
Sirohydrochlorin
C05779  
Apoferritin
C05780  
Apotransferrin
C05781  
Oxyhemoglobin
C05782  
Myoglobin
C05783  
Cytochrome a
C05784  
Catalase
C05785  
Peroxidase
C05786  
(3Z)-Phycocyanobilin
C05787  
Bilirubin beta-diglucuronide
C05789  
L-Urobilinogen
C05790  
I-Urobilinogen
C05791  
D-Urobilinogen
C05793  
L-Urobilin
C05794  
Urobilin
C05795  
D-Urobilin
C05797  
Pheophytin a
C05798  
Bacterio-pheophytins
C05912  
(3Z)-Phycoerythrobilin
C05913  
(3Z)-Phytochromobilin
C06319  
Precorrin 6Y
C06320  
Precorrin 6X
C06399  
Hydrogenobyrinate
C06406  
Precorrin 3B
C06407  
Precorrin 4
C06408  
Precorrin 8X
C06416  
Precorrin 5
C06503  
Hydrogenobyrinate a,c diamide
C06504  
Cob(II)yrinate a,c diamide
C06505  
Cob(I)yrinate a,c diamide
C06506  
Adenosyl cobyrinate a,c diamide
C06507  
Adenosyl cobyrinate hexaamide
C06508  
Adenosyl cobinamide
C06509  
Adenosyl cobinamide phosphate
C06510  
Adenosine-GDP-cobinamide
C11242  
Bacterio-chlorophyll a
C11243  
Bacterio-chlorophyll b
C11538  
Cobalt-sirohydrochlorin
C11539  
Cobalt-precorrin 3
C11540  
Cobalt-precorrin 4
C11542  
Cobalt-precorrin 6
C11543  
Cobalt-dihydro-precorrin 6
C11545  
Cobalt-precorrin 8
C11630  
15,16-Dihydrobiliverdin
C11829  
13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester
C11830  
13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester
C11831  
Divinylprotochlorophyllide
C11832  
Divinyl chlorophyllide a
C11850  
Divinylchlorophyll a
C11851  
Zn-Bacterio-chlorophyll a
C12147  
L-Threonine O-3-phosphate
C14818  
Fe2+
C14819  
Fe3+
C15670  
Heme A
C15672  
Heme O
C16242  
Cobalt-precorrin 5A
C16243  
Cobalt-precorrin 5B
C16244  
Cobalt-precorrin 7
C16540  
7(1)-Hydroxychlorophyllide a
C16541  
Chlorophyllide b
C17401  
Cobalt-factor III
C18021  
Pheophorbide a
C18022  
Red chlorophyll catabolite
C18064  
Pyropheophorbide a
C18098  
Primary fluorescent chlorophyll catabolite
C18151  
7(1)-Hydroxychlorophyll a
C18152  
3-Vinylbacteriochlorophyllide a
C18153  
3-Hydroxyethylbacteriochlorophyllide a
C18154  
3-Hydroxyethylchlorophyllide a
C18155  
Bacteriochlorophyllide a
C18156  
Bacteriochlorophyllide b
C18157  
3-Vinylbacteriochlorophyllide d
C18160  
Bacteriochlorophyllide d
C18161  
Bacteriochlorophyllide c
C18162  
Bacteriochlorophyll d
C18163  
Bacteriochlorophyll c
Reference
PMID:9461500
  Authors
Woodcock SC, Raux E, Levillayer F, Thermes C, Rambach A, Warren MJ.
  Title
Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of sirohaem synthase (CysG) on sirohaem and cobalamin biosynthesis.
  Journal
Biochem J 330:121-9 (1998)
Reference
  Authors
Johansson P, Hederstedt L
  Title
Organization of genes for tetrapyrrole biosynthesis in gram--positive bacteria.
  Journal
Microbiology 145 ( Pt 3):529-38 (1999)
Reference
  Authors
Maggio-Hall LA, Escalante-Semerena JC.
  Title
In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes.
  Journal
Proc Natl Acad Sci USA 96:11798-803 (1999)
Reference
  Authors
Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ.
  Title
The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway.
  Journal
J Biol Chem 275:40316-23 (2000)
Reference
  Authors
Scott AI, Roessner CA.
  Title
Biosynthesis of cobalamin (vitamin B(12)).
  Journal
Biochem Soc Trans 30:613-20 (2002)
Reference
  Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
  Title
The biosynthesis of adenosylcobalamin (vitamin B12).
  Journal
Nat Prod Rep 19:390-412 (2002)
Reference
  Authors
Roessner CA, Huang KX, Warren MJ, Raux E, Scott AI.
  Title
Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. shermanii).
  Journal
Microbiology 148:1845-53 (2002)
Reference
  Authors
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
  Title
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
  Journal
Plant Cell 13:965-78 (2001)
Reference
  Authors
Chew AG, Bryant DA
  Title
Chlorophyll biosynthesis in bacteria: the origins of structural and functional diversity.
  Journal
Annu Rev Microbiol 61:113-29 (2007)
Reference
  Authors
Frigaard NU, Chew AG, Li H, Maresca JA, Bryant DA
  Title
Chlorobium tepidum: insights into the structure, physiology, and metabolism of a  green sulfur bacterium derived from the complete genome sequence.
  Journal
Photosynth Res 78:93-117 (2003)
Reference
  Authors
Deery E, Schroeder S, Lawrence AD, Taylor SL, Seyedarabi A, Waterman J, Wilson KS, Brown D, Geeves MA, Howard MJ, Pickersgill RW, Warren MJ
  Title
An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis.
  Journal
Nat Chem Biol 8:933-40 (2012)
Reference
  Authors
Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SE, Warren MJ
  Title
Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12).
  Journal
Proc Natl Acad Sci U S A 110:14906-11 (2013)
KO pathway
 

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