KEGG T01215: HMPREF0675

Propionibacterium acnes SK137: HMPREF0675_5143

Entry

HMPREF0675_5143 CDS T01215

Definition

biotin-requiring enzyme

Orthology

K00627

pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12]

Organism

pak Propionibacterium acnes SK137

Pathway

pak00010	Glycolysis / Gluconeogenesis
pak00020	Citrate cycle (TCA cycle)
pak00620	Pyruvate metabolism
pak01100	Metabolic pathways
pak01110	Biosynthesis of secondary metabolites
pak01120	Microbial metabolism in diverse environments

Module

pak_M00307

Pyruvate oxidation, pyruvate => acetyl-CoA

Class

Metabolism; Carbohydrate metabolism; Glycolysis / Gluconeogenesis [PATH:pak00010]
Metabolism; Carbohydrate metabolism; Citrate cycle (TCA cycle) [PATH:pak00020]
Metabolism; Carbohydrate metabolism; Pyruvate metabolism [PATH:pak00620]

SSDB

Motif

Pfam:

2-oxoacid_dh Biotin_lipoyl E3_binding Biotin_lipoyl_2 HlyD_3 DUF3248 GCV_H

Other DBs

NCBI-GI:

295131603

NCBI-GeneID:

9074285

UniProt:

D4HAT8

Position

complement(2201994..2203418)

AA seq 474 aa
MKNYCMPDPGEGLTEGEVVSWRVSPGDTVKINDVLCEVETAKSIVELPSPFAGTVAKLCA
EPGETVAVGEPLVTIDDGSDDQPEEEPEFLVGHLTAESGRRRRRRRGAAVSAERAPEKAL
QTPTLKTGPETDVEPVPEPVQPTQPRRQDPPRMDRAGHVLAKPPARRLAADLGIDLSTVT
GTGPQGAVTRSDVKAAAEAGRQAAPEPPVVGASAGDAEFATLSVMSRRLLGGAPTEPDGH
TRRVPVRGVRKVTAKAMKDSLDTKALVTAFLTCDVTPTMDLVARLRADRRFKGLRVSPLT
IWCKAVCLAMGRTPVVNARWDDAADQIVFRDQINLGIAAATPRGLMVPVVRNAQDMTMLE
LAEEITRIVAIAKEGKLQPTDYTDGTFSITNVGVFGLDAGTPVVNRTESAILVLGTIARR
PWVVGTGDDEEVVPRWVTTMSLGFDHRLIDGEEGSTFLHDVAEILSDPASAMLY

NT seq 1425 nt +upstreamnt +downstreamnt
gtgaagaactactgcatgcccgacccgggcgaagggctcaccgagggagaggtcgtctcc
tggcgggtgtctcccggtgacaccgtcaagatcaacgacgtgctgtgcgaggtcgagacg
gccaagtcgatcgtcgaactccccagccctttcgccgggaccgtggcgaagctgtgtgcc
gagcccggcgagacggtggctgtgggagagccactggtgaccattgacgacggttccgac
gaccaacccgaggaggagccggagttcctcgtcggtcacctgaccgcggagtccggacgt
cgacgccgtcgtcgcaggggagctgcggtgtcggctgaaagggcacccgagaaggccctc
cagacgccgaccctcaagaccggtccagagactgatgtcgagcccgttcccgaacctgtg
cagccgacacagcccaggcgccaggatccgccgcgcatggaccgcgccgggcatgtcctc
gccaagcccccggcccgacgtctggctgccgacctcggcatcgacctctcgacggtgacg
ggcaccggcccgcagggggcggtgacgaggagcgacgtcaaggcggcagcggaggccggt
cgtcaagccgcgcctgaaccacctgtcgtcggtgcctctgctggcgacgctgagttcgcg
accctgtcggtgatgtctcgtcgtctcctcggcggtgccccgaccgagcctgacggccac
actcgcagggtcccggtgcgcggcgtccgcaaagtgactgccaaggcgatgaaggattcc
ctggacaccaaggccctcgtgacggccttcctcacctgcgacgtcaccccgacgatggac
ctcgtcgcccggctgcgtgccgaccgcaggttcaagggactgcgcgtctccccgctgacc
atctggtgcaaggcggtgtgcctggcgatgggacgcaccccggtcgtcaacgcccgctgg
gacgacgccgccgaccagatcgtcttccgcgaccagatcaacctcggcatcgccgcggcc
accccgcgcggcctcatggtgcccgtggtgcgcaacgcccaggacatgacgatgctcgag
ctggccgaggagatcacccgcatcgtcgccatcgccaaggagggaaagctccagcccacc
gactacaccgacggcaccttctcgatcaccaatgttggggtgtttggccttgacgcaggg
actccggtcgtcaaccgcaccgaatcggcgatcctcgttctcgggacgatcgctcgacgt
ccgtgggtcgtcgggaccggtgacgatgaggaggtcgtgcccaggtgggtgacgacgatg
agcctcggcttcgaccatcgcctcattgacggcgaggagggctcgaccttcctccatgac
gttgcggagattctctcggacccggcctcggcaatgctgtactga

All links

Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (27)   

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