KEGG   Pteropus alecto (black flying fox): 102879346Help
Entry
102879346         CDS       T02993                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
pale  Pteropus alecto (black flying fox)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:pale00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    102879346 (INSR)
   04015 Rap1 signaling pathway
    102879346 (INSR)
   04010 MAPK signaling pathway
    102879346 (INSR)
   04066 HIF-1 signaling pathway
    102879346 (INSR)
   04068 FoxO signaling pathway
    102879346 (INSR)
   04072 Phospholipase D signaling pathway
    102879346 (INSR)
   04022 cGMP - PKG signaling pathway
    102879346 (INSR)
   04151 PI3K-Akt signaling pathway
    102879346 (INSR)
   04152 AMPK signaling pathway
    102879346 (INSR)
   04150 mTOR signaling pathway
    102879346 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    102879346 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    102879346 (INSR)
   04923 Regulation of lipolysis in adipocyte
    102879346 (INSR)
   04913 Ovarian Steroidogenesis
    102879346 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102879346 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    102879346 (INSR)
   04213 Longevity regulating pathway - multiple species
    102879346 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    102879346 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    102879346 (INSR)
   04931 Insulin resistance
    102879346 (INSR)
Enzymes [BR:pale01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     102879346 (INSR)
Protein kinases [BR:pale01001]
 Tyrosine protein kinases
  InsR family [OT]
   102879346 (INSR)
Enzyme-linked receptors [BR:pale01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   102879346 (INSR)
Cytokine receptors [BR:pale04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   102879346 (INSR)
CD molecules [BR:pale04090]
 Proteins
  102879346 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
Un
AA seq 1341 aa AA seqDB search
AAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMI
TDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYSLMNITRGSV
RIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQ
FVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSEPGDPTKCTACRNFYLDGRC
VETCPPPYYHFQDWRCVNFSFCLHLHNKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSS
NLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEAN
LGLIEEISGYLKIRRSYALVSLAFFRKLRLIRGDTLEVGNYSFYALDNQNLRQLWDWSKH
HLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSN
IRTSFDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPP
LRSNDPKSQSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSV
PLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELYELDYCLKGLKLPSRT
WSPPSESEGSQKHNQSEYDDAAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPR
PSRKRRALGDVENVTTVAPTAPSFPNTSWTSVPTSLEEHRPFEKVVNKESLVISGLRHFT
GYRIELQACNQDAPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKE
PNGLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSW
TEATYFYVTDYHVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNP
EYLSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVK
TVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRS
LRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGD
FGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTASSDMWSFGVVLWEITSLAEQPY
QGLSNEQVLKFVMDGGYLDQPDNCPERLTELMRMCWQFNPKMRPTFLEIVDLLKDDLHPS
FPEVSFFHSEENKAPESEELEMEFEDMESVPLDRSSHSQREEDGGSTLGLKRNYEDHVPY
THMNGGKKNGRVLTLPRSSPS
NT seq 4026 nt NT seq  +upstreamnt  +downstreamnt
gccgccggccatctgtaccccggagaggtatgtcccggcatggatatccggaacaacctc
acgaggctgcacgagctggccaactgctcggtcatcgaaggacatttgcagatactgttg
atgttcaaaacgaggcctgaggacttccgagacctcagtttccccaaactcatcatgatc
actgattacttgctgctcttccgggtctatgggctggagagcctgaaggacctgttcccc
aacctcacggtcatccggggctcccgtctcttcttcaactacgcgctggtcatcttcgag
atggttcacctgaaggagcttggcctctacagcctgatgaacatcacccggggctctgtc
cgcatcgagaagaacaatgagctctgttacctggccaccatcgactggtcacgcatcctg
gattcggtggaggataattacatcgtgctgaacaaggacgacaacgaggagtgtggggac
atctgtccaggcactgcgaagggcaagaccaactgccctgccaccgtcatcaacgggcag
tttgtggagcggtgttggactcacagccattgccagaaagtctgcccgaccatctgtaaa
tcgcacggctgcaccgccgaaggcctctgctgccacagcgagtgcctgggcaactgctcc
gagcccggcgaccccaccaagtgcacggcctgccgcaacttctacctggacggccggtgt
gtggagacctgcccgcccccgtactaccacttccaggactggcgttgcgtgaacttcagc
ttctgcctgcacctgcacaacaaatgcaagaactctcggaggcagggctgccaccagtat
gtcattcacaataataagtgcatccctgaatgtccctccggatacacgatgaattccagc
aacctgatgtgcactccgtgtctaggcccttgtcccaaggtctgtcacctcctggaagga
gagaagaccatcgactcggtgacgtccgcccaggagctccgaggctgcaccgtcatcaat
gggagccttatcatcaacattcgagggggcaacaatctggcagctgagctagaggccaac
ctcggcctcattgaagaaatttcagggtatctgaaaatccgccgttcctacgccctcgtg
tctcttgccttcttccggaagctacgtctgattcggggggataccttggaagtcgggaac
tactctttctatgccttggacaaccagaacctgaggcagctgtgggactggagcaaacac
cacctcaccatcactcaggggaaactcttcttccactataatcccaagctctgcttgtcg
gaaattcacaaaatggaggaagtttcaggaaccaaggggcgccaggagaggaacgacatc
gccctgaagaccaatggggaccaggcatcctgtgaaaatgaattacttaaattttctaac
attcggacgtcttttgacaagatcttgctgaaatgggagccgtactggccccccgacttc
cgagacctcctaggcttcatgctgttctacaaagaggccccttatcagaatgtgacagag
ttcgatgggcaggatgcatgtggctccaacagctggacggtggtggacattgacccacct
ttgaggtccaacgaccctaagtcacagagccaccccgggtggctgatgcggggtctgaag
ccctggacccagtatgccatcttcgtcaagaccttggtcaccttttctgatgaacgtcgc
acatatggggccaagagtgacatcatctatgtccagacagatgccaccaatccttctgtc
cccctggaccccatctcggtttccaactcctcatcccagatcatcctgaagtggaagcct
ccttctgaccccaacggcaacatcactcactacctggttttctgggagaggcaggcagag
gacagtgagctgtatgagctggattattgcctcaaagggctgaagctgccctcccggacc
tggtctccgccgtcggagtcggagggttcccagaagcacaaccagagtgagtacgatgat
gccgccggcgaatgctgctcctgccccaagaccgactctcagatcctgaaggagctagag
gagtcgtcgttccggaagacattcgaggactacctgcacaatgtggtttttgtccccagg
ccatcgaggaagcgcagggcccttggcgacgtggagaatgtgacgacggtcgcacccacg
gccccgagttttcccaacacctcctggaccagtgtgcccacgagcttggaggagcaccgg
cccttcgagaaagtggtgaacaaagagtcgctggtcatctccggcctgcgccacttcacc
ggctatcgcatcgagctgcaggcttgcaaccaggatgcgcccgaggaaaggtgcagtgtg
gcagcctacgtcagcgccaggaccatgccggaagccaaggcagatgacatcgttggcccc
gtgacccacgaaatcttcgagaacaacgttgttcacttgatgtggcaggagccgaaggaa
cccaacggtctgattgtgctgtatgaagtgagctatcgacgatacggcgatgaggagctg
cacctctgtgtctcccgcaggcatttcgctctggagcggggctgcaggctgcgtgggctg
cccccggggaattacagcgtgcgagtgcgggccacctccctggcaggcaatggctcctgg
acggaagccacctatttctacgtgacagactaccacgtcccatcaaatattgcaaaaatt
atcatcggtcccctcatctttgtcttcctcttcagcgttgtgatcggaagcatttatctg
ttcctgaggaagaggcagccagatgggcccctgggaccgctgtatgcttcttcaaaccct
gagtacctcagtgccagtgatgtgttcccctgttctgtgtatgtgccggacgagtgggag
gtgcctcgggagaagatcaccctcctgcgagagctggggcagggctccttcggcatggtg
tatgagggcaacgccaaggacatcatcaagggtgaggcagagacccgggtggcggtgaag
acggtcaacgagtcggccagcctgcgtgagcgcatcgagtttctcaacgaggcctcggtc
atgaagggcttcacctgccatcacgtggtccgcctcctgggggtggtgtccaaggggcag
ccgacactggtggtgatggagctgatggcccatggagacctgaagagctaccttcgttcc
ctgcggcctgaggctgagaacaaccctggccgccctcccccgaccctgcaagagatgatc
cagatggcggcggagatcgcggacgggatggcgtacctgaacgccaagaagttcgtgcac
cgggacctcgcagctcgaaactgcatggttgcccatgatttcaccgtcaaaatcggagac
tttggaatgaccagagacatctacgagacggattactaccggaaagggggcaagggcctg
ctccccgtgcggtggatggcgccggaatccctgaaggatggggtcttcactgcttcttca
gacatgtggtccttcggcgtggtcctctgggaaatcaccagcttggcagaacagccttac
caaggcctgtctaatgagcaggtgttgaaatttgtcatggatggagggtatctggatcaa
cccgacaattgtccagagagactcaccgagctgatgcgcatgtgctggcagttcaacccc
aagatgcggccgaccttcctggagatcgtcgacctgctcaaggacgacctgcaccccagc
tttccggaagtttccttcttccacagtgaggagaacaaggcgcccgagagcgaggagttg
gagatggagtttgaggacatggagagcgtccccctggaccggtcctcacactctcagagg
gaagaggacggagggtccacgctgggcctgaagcggaattacgaggatcacgtcccctac
acccacatgaacgggggcaagaaaaacgggcgggtcctgactctgccacggtctagtcct
tcctaa

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