KEGG   Pteropus alecto (black flying fox): 102882079
Entry
102882079         CDS       T02993                                 
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
pale  Pteropus alecto (black flying fox)
Pathway
pale01521  EGFR tyrosine kinase inhibitor resistance
pale04062  Chemokine signaling pathway
pale04148  Efferocytosis
pale04151  PI3K-Akt signaling pathway
pale04217  Necroptosis
pale04550  Signaling pathways regulating pluripotency of stem cells
pale04630  JAK-STAT signaling pathway
pale04658  Th1 and Th2 cell differentiation
pale04659  Th17 cell differentiation
pale04725  Cholinergic synapse
pale04917  Prolactin signaling pathway
pale04920  Adipocytokine signaling pathway
pale04933  AGE-RAGE signaling pathway in diabetic complications
pale04935  Growth hormone synthesis, secretion and action
pale05140  Leishmaniasis
pale05145  Toxoplasmosis
pale05152  Tuberculosis
pale05161  Hepatitis B
pale05164  Influenza A
pale05167  Kaposi sarcoma-associated herpesvirus infection
pale05168  Herpes simplex virus 1 infection
pale05200  Pathways in cancer
pale05207  Chemical carcinogenesis - receptor activation
pale05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pale05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pale00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    102882079 (JAK2)
   04151 PI3K-Akt signaling pathway
    102882079 (JAK2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    102882079 (JAK2)
  09143 Cell growth and death
   04217 Necroptosis
    102882079 (JAK2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    102882079 (JAK2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    102882079 (JAK2)
   04659 Th17 cell differentiation
    102882079 (JAK2)
   04062 Chemokine signaling pathway
    102882079 (JAK2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    102882079 (JAK2)
   04917 Prolactin signaling pathway
    102882079 (JAK2)
   04935 Growth hormone synthesis, secretion and action
    102882079 (JAK2)
  09156 Nervous system
   04725 Cholinergic synapse
    102882079 (JAK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102882079 (JAK2)
   05207 Chemical carcinogenesis - receptor activation
    102882079 (JAK2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102882079 (JAK2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    102882079 (JAK2)
   05164 Influenza A
    102882079 (JAK2)
   05168 Herpes simplex virus 1 infection
    102882079 (JAK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102882079 (JAK2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    102882079 (JAK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102882079 (JAK2)
   05140 Leishmaniasis
    102882079 (JAK2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102882079 (JAK2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102882079 (JAK2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102882079 (JAK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pale01001]
    102882079 (JAK2)
Enzymes [BR:pale01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     102882079 (JAK2)
Protein kinases [BR:pale01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   102882079 (JAK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl ABC1 FERM_C_FAK1 Kinase-like RIO1 FERM_M
Other DBs
NCBI-GeneID: 102882079
NCBI-ProteinID: XP_006918443
Position
Unknown
AA seq 1132 aa
MEMACLTMTEMEGTSMSPVHQNGDIPGNANSVKQIDSVLQVYLYHSLGKTEGDYLKFPSG
EYVAEEICVAASKACGITPVYHSMFALMNETERMWYPPNHVFHVDDSARHNVLYRIRYYF
PYWYCNGSNRTYRHGISRGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLG
MAVLDMMRIAKEKDQTPLDIYSSVSYKTFLPKCVRAKIQEYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR
GKRKESETLTEQDLQLYCDFPDIIDVSIKQANQEVSNESRIVTIHKQDGKNLEVELNSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPTVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCNPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLNGTKKNFSNLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGISDVPTSPTLLRHNNVNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA
MHFLEEKTLFHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKSLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRHLALRVDQIRDSMAG
NT seq 3399 nt   +upstreamnt  +downstreamnt
atggaaatggcttgccttacaatgacggaaatggaaggaacatccatgtctcctgtacat
cagaatggtgatattcctggaaatgccaattctgtgaagcaaatagactcagttctacag
gtgtatctttatcattcccttgggaaaactgagggcgattacctgaagtttccaagtggg
gagtatgttgcagaagaaatttgtgttgctgcttctaaagcctgtggaatcacacctgtg
tatcatagtatgtttgctttaatgaatgaaacagaaaggatgtggtatccacccaaccat
gtcttccatgtagatgactcagccagacataatgtactctacagaataagatattacttt
ccttactggtattgtaatggcagcaacagaacctatcgacatggaatatctcgaggtgct
gaagctcctcttcttgacgactttgtcatgtcgtacctttttgctcagtggcgtcatgat
tttttgcatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg
atggcagtgttagatatgatgagaatagctaaagaaaaggatcaaaccccactggacatc
tatagctctgtcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagaa
tatcatattttgacaaggaaaagaataaggtacagatttcgcagatttattgagcaattc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacgtaaagaaagtgagacactgacagaacaggatttacagttatattgtgatttt
cctgatattattgatgtcagtattaagcaggcaaaccaggaagtctcaaatgaaagcaga
attgtcactatccataagcaagatggtaaaaatctggaagttgaacttaactcattaaga
gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat
cattacctctgtaaagaagtagcgcctccaacggtgcttgaaaatatacaaagcaactgt
catggcccaatttcaatggattttgccatcagtaaactgaagaaagcaggtaatcagact
ggactctatgtacttcgatgcaatcctaaggactttaataaatattttttgacttttgct
gtagagcgagaaaatgtcattgaatataagcattgtttgattacaaaaaatgaaaatgga
gaatacaacctaaacggaactaagaagaacttcagtaatcttaaagatcttttgaattgc
taccagatggaaactgttcgctcagacaatataattttccagtttacgaaatgctgtccc
ccaaagccaaaagataaatcaaaccttctagtctttagaaccaatggtatttctgatgta
ccaacctcaccaacattattgaggcataataacgtgaaccaaatggtttttcacaaaatt
agaaatgaagatttgatatttaatgaaagccttggccaaggcacttttacaaaaattttt
aaaggtgtaagaagagaagtgggagactatggtcaactgcatgaaacagaagtcctttta
aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagtatg
atgagccagctttctcacaagcatctggttttaaattatggagtatgtgtctgtggagag
gagaatattctggttcaggagtttgtgaaatttggatcattagacacatatttgaaaaag
aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaaaccctttttcatgggaatgtgtgcgccaaaaatattcta
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaagagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaagtctaaacttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataagcctctcagtgctttggattctcaa
agaaaactacagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta
gcaaatcttattaataattgtatggattatgaaccagattttagaccttctttcagagcc
attatacgagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac
atgctaccaaatatgaggataggtgccctggggttttctggtgcttttgaagaccgagac
cctacacagtttgaagagagacacttgaaatttctgcagcaactaggcaagggtaatttt
gggagtgtggagatgtgccggtatgaccctctacaagacaacactggggaggtggtggct
gtgaaaaagctccagcacagcactgaagagcacctcagagattttgaaagggaaattgaa
atccttaaatctctacagcatgacaacattgtaaagtacaagggagtgtgctacagtgct
ggccggcgtaacctaagattaattatggaatatttaccatatggaagtttacgagactat
cttcaaaagcataaagaacggatagatcataaaaaacttctgcagtacacatctcaaata
tgcaagggtatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaagg
aatatattggtggagaatgaaaacagagttaaaattggagattttgggttaaccaaagtc
ttgccacaagacaaagaatactataaagtgaaagaacctggtgaaagtcccatattctgg
tatgctccagaatcactgacagagagcaagttttctgtggcctcagatgtttggagtttt
ggagtagttctttatgaacttttcacatatattgagaagagtaaaagtcctccagcggaa
ttcatgcgtatgattggcaatgacaaacaagggcagatgattgtatttcatttgatagaa
ctcctgaagaataatggaagattaccaagaccagatggatgcccagatgagatttatgta
atcatgacagaatgctggaacaataatgtaaatcaacgcccctctttcagacacctcgct
cttcgagttgatcaaataagggacagcatggctggataa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (25)   
   KEGG PATHWAY (25)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (10)   
   Pfam (10)   
All databases (59)   

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