Tryptophan metabolism

Melatonin biosynthesis, tryptophan => serotonin => melatonin [PATH:hsa00380]

Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:hsa00380]

Glutaric acidemia

Acatalasia

Brunner syndrome

Delayed sleep phase syndrome

Peters anomaly

Aromatic L-amino acid decarboxylase (AADC) deficiency

Primary congenital glaucoma (PCG)

Cyanamide (JP16)

Disulfiram (JP16/USP/INN)

Methyldopa hydrate (JP16)

Phenelzine sulfate (USP)

Carbidopa hydrate (JP16)

Selegiline hydrochloride (JAN/USP)

Tranylcypromine sulfate (USP XXI)

Lazabemide hydrochloride (JAN/USAN)

Amezinium metilsulfate (JAN)

Benserazide hydrochloride (JP16)

Safrazine hydrochloride (JAN)

Toloxatone (INN)

Brofaromine (INN)

Moclobemide (USAN/INN)

Rasagiline mesylate (USAN)

Befloxatone (INN)

Pargyline hydrochloride (USAN)

Iproniazid (INN)

Isocarboxazid (INN)

Cimoxatone (INN)

Benserazide (USAN/INN)

Ladostigil tartrate (USAN)

Clorgiline (INN)

Caroxazone (USAN/INN)

Selegiline (USAN/INN)

Mofegiline hydrochloride (USAN)

Lazabemide (USAN/INN)

Milacemide hydrochloride (USAN)

Minaprine (USAN/INN)

Minaprine hydrochloride (USAN)

Nialamide (INN)

Iproclozide (INN)

Iproniazid phosphate

Methyldopa (INN)

Phenelzine (BAN)

Pirlindole (INN)

Pirlindole hydrochloride

Pargyline (INN)

Rasagiline (USAN/INN)

Tranylcypromine (INN)

TDO2; tryptophan 2,3-dioxygenase [KO:K00453] [EC:1.13.11.11]

IDO1; indoleamine 2,3-dioxygenase 1 [KO:K00463] [EC:1.13.11.52]

IDO2; indoleamine 2,3-dioxygenase 2 [KO:K00463] [EC:1.13.11.52]

AFMID; arylformamidase [KO:K01432] [EC:3.5.1.9]

KMO; kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) [KO:K00486] [EC:1.14.13.9]

KYNU; kynureninase [KO:K01556] [EC:3.7.1.3]

HAAO; 3-hydroxyanthranilate 3,4-dioxygenase [KO:K00452] [EC:1.13.11.6]

ACMSD; aminocarboxymuconate semialdehyde decarboxylase [KO:K03392] [EC:4.1.1.45]

OGDHL; oxoglutarate dehydrogenase-like [KO:K00164] [EC:1.2.4.2]

OGDH; oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) [KO:K00164] [EC:1.2.4.2]

GCDH; glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]

HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [KO:K07515] [EC:1.1.1.211 4.2.1.17]

EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:5.3.3.8 1.1.1.35 4.2.1.17]

ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial [KO:K07511] [EC:4.2.1.17]

HADH; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]

ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]

ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]

CCBL2; cysteine conjugate-beta lyase 2 [KO:K00816] [EC:2.6.1.64 4.4.1.13 2.6.1.7]

CCBL1; cysteine conjugate-beta lyase, cytoplasmic [KO:K00816] [EC:2.6.1.64 4.4.1.13 2.6.1.7]

AADAT; aminoadipate aminotransferase [KO:K00825] [EC:2.6.1.39 2.6.1.7]

TPH2; tryptophan hydroxylase 2 [KO:K00502] [EC:1.14.16.4]

TPH1; tryptophan hydroxylase 1 [KO:K00502] [EC:1.14.16.4]

DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) [KO:K01593] [EC:4.1.1.28]

MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]

MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]

ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]

ALDH3A2; aldehyde dehydrogenase 3 family, member A2 [KO:K00128] [EC:1.2.1.3]

ALDH1B1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]

ALDH7A1; aldehyde dehydrogenase 7 family, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]

ALDH9A1; aldehyde dehydrogenase 9 family, member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]

AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]

ASMT; acetylserotonin O-methyltransferase [KO:K00543] [EC:2.1.1.4]

AANAT; aralkylamine N-acetyltransferase [KO:K00669] [EC:2.3.1.87]

CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1 [KO:K07408] [EC:1.14.14.1]

CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 [KO:K07409] [EC:1.14.14.1]

CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 [KO:K07410] [EC:1.14.14.1]

INMT; indolethylamine N-methyltransferase [KO:K00562] [EC:2.1.1.96 2.1.1.49]

IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]

ABP1; amiloride binding protein 1 (amine oxidase (copper-containing)) [KO:K11182] [EC:1.4.3.22]

CAT; catalase [KO:K03781] [EC:1.11.1.6]

FAD

Acetyl-CoA

L-Tryptophan

Anthranilate

2-Oxoadipate

L-Kynurenine

Indolepyruvate

Acetoacetyl-CoA

Tryptamine

Indole

Glutaryl-CoA

3-Hydroxyanthranilate

Indole-3-acetaldehyde

5-Hydroxy-L-tryptophan

Serotonin

Crotonoyl-CoA

Indole-3-acetate

Indole-3-ethanol

N-Acetylserotonin

7,8-Dihydroxykynurenate

(S)-3-Hydroxybutanoyl-CoA

7,8-Dihydro-7,8-dihydroxykynurenate

4-(2-Aminophenyl)-2,4-dioxobutanoate

FADH2

Melatonin

4-Hydroxy-2-quinolinecarboxylic acid

2-Aminophenol

Indolelactate

2-Aminophenoxazin-3-one

N-Acetylisatin

2-Aminomuconate

N-Acetylindoxyl

Xanthurenic acid

(Indol-3-yl)acetamide

L-Formylkynurenine

2,3-Dihydroxyindole

Indole-3-acetaldehyde oxime

3-Indoleacetonitrile

3-Hydroxy-L-kynurenine

(Indol-3-yl)glycolaldehyde

gamma-Oxalocrotonate

2-Formylaminobenzaldehyde

Quinolinate

2-Aminomuconate semialdehyde

2-Amino-3-carboxymuconate semialdehyde

5-Hydroxyindoleacetaldehyde

5-Hydroxyindoleacetate

3-Hydroxykynurenamine

4,8-Dihydroxyquinoline

5-Hydroxykynurenamine

4,6-Dihydroxyquinoline

Cinnavalininate

5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate

Formyl-N-acetyl-5-methoxykynurenamine

6-Hydroxymelatonin

3-Methylindolepyruvate

4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate

5-Hydroxyindolepyruvate

Formyl-5-hydroxykynurenamine

5-Hydroxy-N-formylkynurenine

5-Hydroxykynurenine

4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate

Formylanthranilate

5-(2'-Formylethyl)-4,6-dihydroxypicolinate

5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate

5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate

Indoxyl

5-Methoxytryptamine

5-Methoxyindoleacetate

6-Hydroxykynurenate

8-Methoxykynurenate

3-Methoxyanthranilate

5-Hydroxyindoleacetylglycine

3-Methyldioxyindole

2-Formaminobenzoylacetate

Glucobrassicin

N-Methylserotonin

N-Methyltryptamine

Indolylmethylthiohydroximate

Indolylmethyl-desulfoglucosinolate

S-(Indolylmethylthiohydroximoyl)-L-cysteine

N-Hydroxyl-tryptamine