KEGG   PATHWAY: hsa00380Help
Entry
hsa00380                    Pathway                                

Name
Tryptophan metabolism - Homo sapiens (human)
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Tryptophan metabolism
hsa00380

All organismsOrtholog table
Module
Melatonin biosynthesis, tryptophan => serotonin => melatonin [PATH:hsa00380]
Disease
H00178  
Glutaric acidemia
H00203  
Acatalasia
H00548  
Brunner syndrome
H00689  
Delayed sleep phase syndrome
H01075  
Peters anomaly
H01161  
Aromatic L-amino acid decarboxylase (AADC) deficiency
H01203  
Primary congenital glaucoma (PCG)
H01364  
3-Hydroxyacyl-CoA dehydrogenase deficiency
Drug
D00123  
Cyanamide (JP16)
D00131  
Disulfiram (JP16/USP/INN)
D00405  
Methyldopa hydrate (JP16)
D00505  
Phenelzine sulfate (USP)
D00558  
Carbidopa hydrate (JP16)
D00785  
Selegiline hydrochloride (JAN/USP)
D00826  
Tranylcypromine sulfate (USP XXI)
D01097  
Lazabemide hydrochloride (JAN/USAN)
D01304  
Amezinium metilsulfate (JAN)
D01653  
Benserazide hydrochloride (JP16)
D01888  
Safrazine hydrochloride (JAN)
D02559  
Toloxatone (INN)
D02560  
Brofaromine (INN)
D02561  
Moclobemide (USAN/INN)
D02562  
Rasagiline mesylate (USAN)
D02563  
Befloxatone (INN)
D02564  
Pargyline hydrochloride (USAN)
D02579  
Iproniazid (INN)
D02580  
Isocarboxazid (INN)
D02581  
Cimoxatone (INN)
D03082  
Benserazide (USAN/INN)
D03239  
Ladostigil tartrate (USAN)
D03248  
Clorgiline (INN)
D03409  
Caroxazone (USAN/INN)
D03731  
Selegiline (USAN/INN)
D03733  
Mofegiline hydrochloride (USAN)
D04681  
Lazabemide (USAN/INN)
D05033  
Milacemide hydrochloride (USAN)
D05039  
Minaprine (USAN/INN)
D05040  
Minaprine hydrochloride (USAN)
D07337  
Nialamide (INN)
D07338  
Iproclozide (INN)
D08085  
Iproniazid phosphate
D08205  
Methyldopa (INN)
D08349  
Phenelzine (BAN)
D08392  
Pirlindole (INN)
D08393  
Pirlindole hydrochloride
D08453  
Pargyline (INN)
D08469  
Rasagiline (USAN/INN)
D08625  
Tranylcypromine (INN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
6999  
TDO2; tryptophan 2,3-dioxygenase [KO:K00453] [EC:1.13.11.11]
3620  
IDO1; indoleamine 2,3-dioxygenase 1 [KO:K00463] [EC:1.13.11.52]
169355  
IDO2; indoleamine 2,3-dioxygenase 2 [KO:K00463] [EC:1.13.11.52]
125061  
AFMID; arylformamidase [KO:K01432] [EC:3.5.1.9]
8564  
KMO; kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) [KO:K00486] [EC:1.14.13.9]
8942  
KYNU; kynureninase [KO:K01556] [EC:3.7.1.3]
23498  
HAAO; 3-hydroxyanthranilate 3,4-dioxygenase [KO:K00452] [EC:1.13.11.6]
130013  
ACMSD; aminocarboxymuconate semialdehyde decarboxylase [KO:K03392] [EC:4.1.1.45]
55753  
OGDHL; oxoglutarate dehydrogenase-like [KO:K00164] [EC:1.2.4.2]
4967  
OGDH; oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) [KO:K00164] [EC:1.2.4.2]
2639  
GCDH; glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
3030  
HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [KO:K07515] [EC:1.1.1.211 4.2.1.17]
1962  
EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:5.3.3.8 1.1.1.35 4.2.1.17]
1892  
ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial [KO:K07511] [EC:4.2.1.17]
3033  
HADH; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]
39  
ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
38  
ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
56267  
CCBL2; cysteine conjugate-beta lyase 2 [KO:K00816] [EC:2.6.1.64 4.4.1.13 2.6.1.7]
883  
CCBL1; cysteine conjugate-beta lyase, cytoplasmic [KO:K00816] [EC:2.6.1.64 4.4.1.13 2.6.1.7]
51166  
AADAT; aminoadipate aminotransferase [KO:K00825] [EC:2.6.1.39 2.6.1.7]
121278  
TPH2; tryptophan hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
7166  
TPH1; tryptophan hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
1644  
DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) [KO:K01593] [EC:4.1.1.28]
4129  
MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4128  
MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
217  
ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
224  
ALDH3A2; aldehyde dehydrogenase 3 family, member A2 [KO:K00128] [EC:1.2.1.3]
219  
ALDH1B1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
501  
ALDH7A1; aldehyde dehydrogenase 7 family, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
223  
ALDH9A1; aldehyde dehydrogenase 9 family, member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
316  
AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
438  
ASMT; acetylserotonin O-methyltransferase [KO:K00543] [EC:2.1.1.4]
15  
AANAT; aralkylamine N-acetyltransferase [KO:K00669] [EC:2.3.1.87]
1543  
CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1 [KO:K07408] [EC:1.14.14.1]
1544  
CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2 [KO:K07409] [EC:1.14.14.1]
1545  
CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 [KO:K07410] [EC:1.14.14.1]
11185  
INMT; indolethylamine N-methyltransferase [KO:K00562] [EC:2.1.1.96 2.1.1.49]
259307  
IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
26  
AOC1; amine oxidase, copper containing 1 [KO:K11182] [EC:1.4.3.22]
847  
CAT; catalase [KO:K03781] [EC:1.11.1.6]
Compound
C00016  
FAD
C00024  
Acetyl-CoA
C00078  
L-Tryptophan
C00108  
Anthranilate
C00322  
2-Oxoadipate
C00328  
L-Kynurenine
C00331  
Indolepyruvate
C00332  
Acetoacetyl-CoA
C00398  
Tryptamine
C00463  
Indole
C00527  
Glutaryl-CoA
C00632  
3-Hydroxyanthranilate
C00637  
Indole-3-acetaldehyde
C00643  
5-Hydroxy-L-tryptophan
C00780  
Serotonin
C00877  
Crotonoyl-CoA
C00954  
Indole-3-acetate
C00955  
Indole-3-ethanol
C00978  
N-Acetylserotonin
C01111  
7,8-Dihydroxykynurenate
C01144  
(S)-3-Hydroxybutanoyl-CoA
C01249  
7,8-Dihydro-7,8-dihydroxykynurenate
C01252  
4-(2-Aminophenyl)-2,4-dioxobutanoate
C01352  
FADH2
C01598  
Melatonin
C01717  
4-Hydroxy-2-quinolinecarboxylic acid
C01987  
2-Aminophenol
C02043  
Indolelactate
C02161  
2-Aminophenoxazin-3-one
C02172  
N-Acetylisatin
C02220  
2-Aminomuconate
C02298  
N-Acetylindoxyl
C02470  
Xanthurenic acid
C02693  
(Indol-3-yl)acetamide
C02700  
L-Formylkynurenine
C02775  
2,3-Dihydroxyindole
C02937  
Indole-3-acetaldehyde oxime
C02938  
3-Indoleacetonitrile
C03227  
3-Hydroxy-L-kynurenine
C03230  
(Indol-3-yl)glycolaldehyde
C03453  
gamma-Oxalocrotonate
C03574  
2-Formylaminobenzaldehyde
C03722  
Quinolinate
C03824  
2-Aminomuconate semialdehyde
C04409  
2-Amino-3-carboxymuconate semialdehyde
C05634  
5-Hydroxyindoleacetaldehyde
C05635  
5-Hydroxyindoleacetate
C05636  
3-Hydroxykynurenamine
C05637  
4,8-Dihydroxyquinoline
C05638  
5-Hydroxykynurenamine
C05639  
4,6-Dihydroxyquinoline
C05640  
Cinnavalininate
C05641  
5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  
Formyl-N-acetyl-5-methoxykynurenamine
C05643  
6-Hydroxymelatonin
C05644  
3-Methylindolepyruvate
C05645  
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  
5-Hydroxyindolepyruvate
C05647  
Formyl-5-hydroxykynurenamine
C05648  
5-Hydroxy-N-formylkynurenine
C05651  
5-Hydroxykynurenine
C05652  
4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  
Formylanthranilate
C05654  
5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  
5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  
5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  
Indoxyl
C05659  
5-Methoxytryptamine
C05660  
5-Methoxyindoleacetate
C05663  
6-Hydroxykynurenate
C05830  
8-Methoxykynurenate
C05831  
3-Methoxyanthranilate
C05832  
5-Hydroxyindoleacetylglycine
C05834  
3-Methyldioxyindole
C05835  
2-Formaminobenzoylacetate
C05837  
Glucobrassicin
C06212  
N-Methylserotonin
C06213  
N-Methyltryptamine
C16516  
Indolylmethylthiohydroximate
C16517  
Indolylmethyl-desulfoglucosinolate
C16518  
S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  
N-Hydroxyl-tryptamine
Reference
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)
KO pathway
 

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