KEGG PATHWAY: hsa04310

PATHWAY: hsa04310

Entry

hsa04310 Pathway

Name

Wnt signaling pathway - Homo sapiens (human)

Description

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.

Class

Environmental Information Processing; Signal transduction

Pathway map

hsa04310

Wnt signaling pathway

Module

hsa_M00380

SCF-BTRC complex [PATH:hsa04310]

Disease

H00078	Frontotemporal lobar degeneration (FTLD)
H00450	Sclerosing bone dysplasias
H00451	Osteoporosis-pseudoglioma syndrome (OPPG)
H00589	Familial exudative vitreoretinopathy (FEVR)
H00598	46,XX disorders of sex development (Disorders of gonadal development)
H00600	46,XX disorders of sex development (Other)
H00607	46,XY disorders of sex development (Disorders of gonadal development)
H00625	Tooth agenesis
H00636	Tetra-amelia
H00646	Odontoonychodermal dysplasia
H00681	Acne inversa
H00810	Progressive myoclonic epilepsy (PME)
H00857	Oligodontia-colorectal cancer syndrome
H00881	Li-Fraumeni syndrome
H00934	Caudal duplication anomaly
H00947	Pilomatricoma
H00949	Focal dermal hypoplasia
H00979	Caudal regression syndrome and Sirenomelia
H01007	Choroid plexus papilloma
H01023	Juvenile polyposis syndrome
H01025	Familial adenomatous polyposis
H01037	Vesicoureteral reflux
H01307	Nonsyndromic congenital nail disorder (NDNC)

Drug

D10094	Blosozumab (USAN)
D10156	Romosozumab (USAN)

Other DBs

BSID:

83061

GO:

0016055

Organism

Homo sapiens (human) [GN:hsa]

Gene

64840	PORCN; porcupine homolog (Drosophila) [KO:K00181]
7471	WNT1; wingless-type MMTV integration site family, member 1 [KO:K03209]
7472	WNT2; wingless-type MMTV integration site family member 2 [KO:K00182]
7482	WNT2B; wingless-type MMTV integration site family, member 2B [KO:K00182]
7473	WNT3; wingless-type MMTV integration site family, member 3 [KO:K00312]
89780	WNT3A; wingless-type MMTV integration site family, member 3A [KO:K00312]
54361	WNT4; wingless-type MMTV integration site family, member 4 [KO:K00408]
7474	WNT5A; wingless-type MMTV integration site family, member 5A [KO:K00444]
81029	WNT5B; wingless-type MMTV integration site family, member 5B [KO:K00444]
7475	WNT6; wingless-type MMTV integration site family, member 6 [KO:K00445]
7476	WNT7A; wingless-type MMTV integration site family, member 7A [KO:K00572]
7477	WNT7B; wingless-type MMTV integration site family, member 7B [KO:K00572]
7478	WNT8A; wingless-type MMTV integration site family, member 8A [KO:K00714]
7479	WNT8B; wingless-type MMTV integration site family, member 8B [KO:K00714]
7483	WNT9A; wingless-type MMTV integration site family, member 9A [KO:K01064]
7484	WNT9B; wingless-type MMTV integration site family, member 9B [KO:K01064]
7480	WNT10B; wingless-type MMTV integration site family, member 10B [KO:K01357]
80326	WNT10A; wingless-type MMTV integration site family, member 10A [KO:K01357]
7481	WNT11; wingless-type MMTV integration site family, member 11 [KO:K01384]
51384	WNT16; wingless-type MMTV integration site family, member 16 [KO:K01558]
9350	CER1; cerberus 1, DAN family BMP antagonist [KO:K01645]
11197	WIF1; WNT inhibitory factor 1 [KO:K01691]
50964	SOST; sclerostin [KO:K16834]
22943	DKK1; dickkopf 1 homolog (Xenopus laevis) [KO:K02165]
27123	DKK2; dickkopf 2 homolog (Xenopus laevis) [KO:K02165]
27121	DKK4; dickkopf homolog 4 (Xenopus laevis) [KO:K02165]
6422	SFRP1; secreted frizzled-related protein 1 [KO:K02166]
6423	SFRP2; secreted frizzled-related protein 2 [KO:K02176]
6424	SFRP4; secreted frizzled-related protein 4 [KO:K02185]
6425	SFRP5; secreted frizzled-related protein 5 [KO:K02222]
8321	FZD1; frizzled family receptor 1 [KO:K02432]
8324	FZD7; frizzled family receptor 7 [KO:K02432]
2535	FZD2; frizzled family receptor 2 [KO:K02235]
7976	FZD3; frizzled family receptor 3 [KO:K02329]
8322	FZD4; frizzled family receptor 4 [KO:K02354]
7855	FZD5; frizzled family receptor 5 [KO:K02375]
8325	FZD8; frizzled family receptor 8 [KO:K02375]
8323	FZD6; frizzled family receptor 6 [KO:K02376]
11211	FZD10; frizzled family receptor 10 [KO:K02842]
8326	FZD9; frizzled family receptor 9 [KO:K02842]
4041	LRP5; low density lipoprotein receptor-related protein 5 [KO:K03068]
4040	LRP6; low density lipoprotein receptor-related protein 6 [KO:K03068]
25805	BAMBI; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) [KO:K10162]
1454	CSNK1E; casein kinase 1, epsilon [KO:K08960] [EC:2.7.11.1]
1857	DVL3; dishevelled, dsh homolog 3 (Drosophila) [KO:K02353]
1856	DVL2; dishevelled, dsh homolog 2 (Drosophila) [KO:K02353]
1855	DVL1; dishevelled, dsh homolog 1 (Drosophila) [KO:K02353]
10023	FRAT1; frequently rearranged in advanced T-cell lymphomas [KO:K03069]
23401	FRAT2; frequently rearranged in advanced T-cell lymphomas 2 [KO:K03096]
1457	CSNK2A1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
1459	CSNK2A2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
1460	CSNK2B; casein kinase 2, beta polypeptide [KO:K03115]
85407	NKD1; naked cuticle homolog 1 (Drosophila) [KO:K03213]
85409	NKD2; naked cuticle homolog 2 (Drosophila) [KO:K03213]
80319	CXXC4; CXXC finger protein 4 [KO:K03344]
59343	SENP2; SUMO1/sentrin/SMT3 specific peptidase 2 [KO:K03345] [EC:3.4.22.68]
2932	GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
1499	CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa [KO:K02105]
8312	AXIN1; axin 1 [KO:K02157]
8313	AXIN2; axin 2 [KO:K04385]
324	APC; adenomatous polyposis coli [KO:K02085]
10297	APC2; adenomatosis polyposis coli 2 [KO:K02085]
122011	CSNK1A1L; casein kinase 1, alpha 1-like [KO:K08957] [EC:2.7.11.1]
1452	CSNK1A1; casein kinase 1, alpha 1 [KO:K08957] [EC:2.7.11.1]
6932	TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
83439	TCF7L1; transcription factor 7-like 1 (T-cell specific, HMG-box) [KO:K04490]
6934	TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box) [KO:K04491]
51176	LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
56998	CTNNBIP1; catenin, beta interacting protein 1 [KO:K04493]
57680	CHD8; chromodomain helicase DNA binding protein 8 [KO:K04494] [EC:3.6.4.12]
64321	SOX17; SRY (sex determining region Y)-box 17 [KO:K04495]
1487	CTBP1; C-terminal binding protein 1 [KO:K04496]
1488	CTBP2; C-terminal binding protein 2 [KO:K04496]
1387	CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
2033	EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
8607	RUVBL1; RuvB-like 1 (E. coli) [KO:K04499]
4089	SMAD4; SMAD family member 4 [KO:K04501]
6885	MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
51701	NLK; nemo-like kinase [KO:K04468] [EC:2.7.11.24]
4609	MYC; v-myc myelocytomatosis viral oncogene homolog (avian) [KO:K04377]
3725	JUN; jun proto-oncogene [KO:K04448]
8061	FOSL1; FOS-like antigen 1 [KO:K04502]
595	CCND1; cyclin D1 [KO:K04503]
894	CCND2; cyclin D2 [KO:K10151]
896	CCND3; cyclin D3 [KO:K10152]
5467	PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
4316	MMP7; matrix metallopeptidase 7 (matrilysin, uterine) [KO:K01397] [EC:3.4.24.23]
5663	PSEN1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
5566	PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
5567	PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
5568	PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
5613	PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
7157	TP53; tumor protein p53 [KO:K04451]
6477	SIAH1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:6.3.2.19]
27101	CACYBP; calcyclin binding protein [KO:K04507]
6500	SKP1; S-phase kinase-associated protein 1 [KO:K03094]
6907	TBL1X; transducin (beta)-like 1X-linked [KO:K04508]
90665	TBL1Y; transducin (beta)-like 1, Y-linked [KO:K04508]
79718	TBL1XR1; transducin (beta)-like 1 X-linked receptor 1 [KO:K04508]
8945	BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase [KO:K03362]
23291	FBXW11; F-box and WD repeat domain containing 11 [KO:K03362]
8454	CUL1; cullin 1 [KO:K03347]
9978	RBX1; ring-box 1, E3 ubiquitin protein ligase [KO:K03868]
2239	GPC4; glypican 4 [KO:K08110]
57216	VANGL2; VANGL planar cell polarity protein 2 [KO:K04510]
81839	VANGL1; VANGL planar cell polarity protein 1 [KO:K04510]
144165	PRICKLE1; prickle homolog 1 (Drosophila) [KO:K04511]
166336	PRICKLE2; prickle homolog 2 (Drosophila) [KO:K04511]
23002	DAAM1; dishevelled associated activator of morphogenesis 1 [KO:K04512]
23500	DAAM2; dishevelled associated activator of morphogenesis 2 [KO:K04512]
387	RHOA; ras homolog family member A [KO:K04513]
6093	ROCK1; Rho-associated, coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
9475	ROCK2; Rho-associated, coiled-coil containing protein kinase 2 [KO:K04514] [EC:2.7.11.1]
5879	RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
5880	RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
5881	RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
5599	MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602	MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601	MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
23236	PLCB1; phospholipase C, beta 1 (phosphoinositide-specific) [KO:K05858] [EC:3.1.4.11]
5330	PLCB2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
5331	PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) [KO:K05858] [EC:3.1.4.11]
5332	PLCB4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
815	CAMK2A; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
817	CAMK2D; calcium/calmodulin-dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
816	CAMK2B; calcium/calmodulin-dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
818	CAMK2G; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
5530	PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
5532	PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
5533	PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
5534	PPP3R1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
5535	PPP3R2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
11261	CHP1; calcineurin-like EF-hand protein 1 [KO:K06268]
63928	CHP2; calcineurin-like EF-hand protein 2 [KO:K06268]
5578	PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
5579	PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
5582	PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
4776	NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 [KO:K04446]
4772	NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [KO:K04446]
10725	NFAT5; nuclear factor of activated T-cells 5, tonicity-responsive [KO:K04446]
4773	NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [KO:K04446]
4775	NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [KO:K04446]
4088	SMAD3; SMAD family member 3 [KO:K04500]

Compound

C00076

Calcium cation

Reference

PMID:14635791

Authors

Hatsell S, Rowlands T, Hiremath M, Cowin P.

Title

Beta-catenin and Tcfs in mammary development and cancer.

Journal

J Mammary Gland Biol Neoplasia 8:145-58 (2003)

Reference

PMID:14745971

Authors

Yang Y.

Title

Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.

Journal

Birth Defects Res Part C Embryo Today 69:305-17 (2003)

Reference

PMID:12446114

Authors

Kalderon D.

Title

Similarities between the Hedgehog and Wnt signaling pathways.

Journal

Trends Cell Biol 12:523-31 (2002)

Reference

PMID:14530294

Authors

Nusse R.

Title

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.

Journal

Development 130:5297-305 (2003)

Reference

PMID:15102436

Authors

Jope RS, Johnson GV.

Title

The glamour and gloom of glycogen synthase kinase-3.

Journal

Trends Biochem Sci 29:95-102 (2004)

Reference

PMID:12967557

Authors

Veeman MT, Axelrod JD, Moon RT.

Title

A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.

Journal

Dev Cell 5:367-77 (2003)

Reference

PMID:11433294

Authors

Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.

Title

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.

Journal

Nat Cell Biol 3:628-36 (2001)

Reference

PMID:23256519

Authors

Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E

Title

The way Wnt works: Components and mechanism.

Journal

Growth Factors 31:1-31 (2013)

Reference

PMID:19482104

Authors

Carethers JM

Title

Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.

Journal

Gastroenterology 137:33-6 (2009)

Reference

PMID:18838381

Authors

Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG

Title

The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.

Journal

J Biol Chem 283:33053-8 (2008)

KO pathway

ko04310

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG MODULE (1)   
   BioSystems (1)   
Disease (23)   
   KEGG DISEASE (23)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (143)   
   KEGG GENES (143)   
All databases (172)   

Download RDF

DBGET integrated database retrieval system