KEGG   PATHWAY: hsa04360Help
Entry
hsa04360                    Pathway                                

Name
Axon guidance - Homo sapiens (human)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development
BRITE hierarchy
Pathway map
Axon guidance
hsa04360

All organismsOrtholog table
Disease
H00577  
Syndromic X-linked mental retardation with epilepsy or seizures
H00698  
Nemaline myopathy
H00764  
Cri du chat syndrome
H01034  
L1 syndrome
H01202  
Cataract
H01287  
Congenital mirror movements (CMM)
Drug
D10028  
Valategrast hydrochloride (USAN)
D10494  
Vesencumab (USAN/INN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
9423  
NTN1; netrin 1 [KO:K06843]
1630  
DCC; deleted in colorectal carcinoma [KO:K06765]
5879  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
5880  
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
5881  
RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
3983  
ABLIM1; actin binding LIM protein 1 [KO:K07520]
22885  
ABLIM3; actin binding LIM protein family, member 3 [KO:K07520]
84448  
ABLIM2; actin binding LIM protein family, member 2 [KO:K07520]
5530  
PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
5532  
PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
5533  
PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
5534  
PPP3R1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
5535  
PPP3R2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
4773  
NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [KO:K17332]
4775  
NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [KO:K17333]
4776  
NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 [KO:K17334]
387  
RHOA; ras homolog family member A [KO:K04513]
6093  
ROCK1; Rho-associated, coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
9475  
ROCK2; Rho-associated, coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
90249  
UNC5A; unc-5 homolog A (C. elegans) [KO:K07521]
219699  
UNC5B; unc-5 homolog B (C. elegans) [KO:K07521]
8633  
UNC5C; unc-5 homolog C (C. elegans) [KO:K07521]
137970  
UNC5D; unc-5 homolog D (C. elegans) [KO:K07521]
4917  
NTN3; netrin 3 [KO:K06844]
59277  
NTN4; netrin 4 [KO:K06845]
22854  
NTNG1; netrin G1 [KO:K07522]
84628  
NTNG2; netrin G2 [KO:K16359]
57689  
LRRC4C; leucine rich repeat containing 4C [KO:K07523]
64101  
LRRC4; leucine rich repeat containing 4 [KO:K16351]
1942  
EFNA1; ephrin-A1 [KO:K05462]
1943  
EFNA2; ephrin-A2 [KO:K05462]
1944  
EFNA3; ephrin-A3 [KO:K05462]
1945  
EFNA4; ephrin-A4 [KO:K05462]
1946  
EFNA5; ephrin-A5 [KO:K05462]
2534  
FYN; FYN oncogene related to SRC, FGR, YES [KO:K05703] [EC:2.7.10.2]
1947  
EFNB1; ephrin-B1 [KO:K05463]
1948  
EFNB2; ephrin-B2 [KO:K05463]
1949  
EFNB3; ephrin-B3 [KO:K05463]
5747  
PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
5998  
RGS3; regulator of G-protein signaling 3 [KO:K07524]
2041  
EPHA1; EPH receptor A1 [KO:K05102] [EC:2.7.10.1]
1969  
EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
2042  
EPHA3; EPH receptor A3 [KO:K05104] [EC:2.7.10.1]
2043  
EPHA4; EPH receptor A4 [KO:K05105] [EC:2.7.10.1]
2044  
EPHA5; EPH receptor A5 [KO:K05106] [EC:2.7.10.1]
285220  
EPHA6; EPH receptor A6 [KO:K05107] [EC:2.7.10.1]
2045  
EPHA7; EPH receptor A7 [KO:K05108] [EC:2.7.10.1]
2046  
EPHA8; EPH receptor A8 [KO:K05109] [EC:2.7.10.1]
2047  
EPHB1; EPH receptor B1 [KO:K05110] [EC:2.7.10.1]
2048  
EPHB2; EPH receptor B2 [KO:K05111] [EC:2.7.10.1]
2049  
EPHB3; EPH receptor B3 [KO:K05112] [EC:2.7.10.1]
2050  
EPHB4; EPH receptor B4 [KO:K05113] [EC:2.7.10.1]
2051  
EPHB6; EPH receptor B6 [KO:K05114] [EC:2.7.10.1]
25  
ABL1; c-abl oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
25791  
NGEF; neuronal guanine nucleotide exchange factor [KO:K07525]
998  
CDC42; cell division cycle 42 [KO:K04393]
5058  
PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
5062  
PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
5063  
PAK3; p21 protein (Cdc42/Rac)-activated kinase 3 [KO:K05733] [EC:2.7.11.1]
10298  
PAK4; p21 protein (Cdc42/Rac)-activated kinase 4 [KO:K05734] [EC:2.7.11.1]
56924  
PAK6; p21 protein (Cdc42/Rac)-activated kinase 6 [KO:K05735] [EC:2.7.11.1]
57144  
PAK7; p21 protein (Cdc42/Rac)-activated kinase 7 [KO:K05736] [EC:2.7.11.1]
5921  
RASA1; RAS p21 protein activator (GTPase activating protein) 1 [KO:K04352]
3265  
HRAS; Harvey rat sarcoma viral oncogene homolog [KO:K02833]
3845  
KRAS; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
4893  
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
7852  
CXCR4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
2770  
GNAI1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 [KO:K04630]
2773  
GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [KO:K04630]
2771  
GNAI2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [KO:K04630]
6585  
SLIT1; slit homolog 1 (Drosophila) [KO:K06838]
9353  
SLIT2; slit homolog 2 (Drosophila) [KO:K06839]
6586  
SLIT3; slit homolog 3 (Drosophila) [KO:K06850]
6091  
ROBO1; roundabout, axon guidance receptor, homolog 1 (Drosophila) [KO:K06753]
6092  
ROBO2; roundabout, axon guidance receptor, homolog 2 (Drosophila) [KO:K06754]
64221  
ROBO3; roundabout, axon guidance receptor, homolog 3 (Drosophila) [KO:K06755]
23380  
SRGAP2; SLIT-ROBO Rho GTPase activating protein 2 [KO:K07526]
57522  
SRGAP1; SLIT-ROBO Rho GTPase activating protein 1 [KO:K07526]
9901  
SRGAP3; SLIT-ROBO Rho GTPase activating protein 3 [KO:K07526]
10371  
SEMA3A; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A [KO:K06840]
7869  
SEMA3B; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B [KO:K06840]
10512  
SEMA3C; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C [KO:K06840]
223117  
SEMA3D; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D [KO:K06840]
9723  
SEMA3E; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E [KO:K06840]
6405  
SEMA3F; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F [KO:K06840]
56920  
SEMA3G; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G [KO:K06840]
5362  
PLXNA2; plexin A2 [KO:K06820]
55558  
PLXNA3; plexin A3 [KO:K06820]
5361  
PLXNA1; plexin A1 [KO:K06820]
8829  
NRP1; neuropilin 1 [KO:K06724]
3897  
L1CAM; L1 cell adhesion molecule [KO:K06550]
2932  
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
1020  
CDK5; cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
2242  
FES; feline sarcoma oncogene [KO:K07527] [EC:2.7.10.2]
1808  
DPYSL2; dihydropyrimidinase-like 2 [KO:K07528]
56896  
DPYSL5; dihydropyrimidinase-like 5 [KO:K07529]
3984  
LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
3985  
LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
1072  
CFL1; cofilin 1 (non-muscle) [KO:K05765]
1073  
CFL2; cofilin 2 (muscle) [KO:K05765]
29984  
RHOD; ras homolog family member D [KO:K07530]
27289  
RND1; Rho family GTPase 1 [KO:K07531]
10505  
SEMA4F; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F [KO:K06521]
10507  
SEMA4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D [KO:K06521]
10509  
SEMA4B; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B [KO:K06521]
54910  
SEMA4C; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C [KO:K06521]
57715  
SEMA4G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G [KO:K06521]
64218  
SEMA4A; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A [KO:K06521]
9037  
SEMA5A; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [KO:K06841]
54437  
SEMA5B; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B [KO:K06841]
57556  
SEMA6A; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A [KO:K06842]
10501  
SEMA6B; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B [KO:K06842]
10500  
SEMA6C; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C [KO:K06842]
80031  
SEMA6D; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D [KO:K06842]
5364  
PLXNB1; plexin B1 [KO:K06821]
23654  
PLXNB2; plexin B2 [KO:K06821]
5365  
PLXNB3; plexin B3 [KO:K06821]
4233  
MET; met proto-oncogene [KO:K05099] [EC:2.7.10.1]
23365  
ARHGEF12; Rho guanine nucleotide exchange factor (GEF) 12 [KO:K07532]
8482  
SEMA7A; semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) [KO:K06529]
3688  
ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
10154  
PLXNC1; plexin C1 [KO:K06572]
4690  
NCK1; NCK adaptor protein 1 [KO:K07365]
6387  
CXCL12; chemokine (C-X-C motif) ligand 12 [KO:K10031]
8440  
NCK2; NCK adaptor protein 2 [KO:K07365]
Compound
C00076  
Calcium cation
Reference
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
Reference
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
Reference
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
Reference
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
Reference
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
Reference
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
Reference
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
Reference
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
Reference
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
Reference
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
KO pathway
 

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