KEGG   PATHWAY: map01056Help
Entry
map01056                    Pathway                                

Name
Biosynthesis of type II polyketide backbone
Class
Metabolism; Metabolism of terpenoids and polyketides
BRITE hierarchy
Pathway map
Biosynthesis of type II polyketide backbone
map01056

All organismsOrtholog table
Reference
  Authors
Rawlings BJ
  Title
Biosynthesis of polyketides (other than actinomycete macrolides).
  Journal
Nat Prod Rep 16:425-84 (1999)
Reference
  Authors
Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A
  Title
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.
  Journal
Nat Prod Rep 24:162-90 (2007)
Reference
  Authors
Moore BS, Hertweck C
  Title
Biosynthesis and attachment of novel bacterial polyketide synthase starter units.
  Journal
Nat Prod Rep 19:70-99 (2002)
Reference
  Authors
Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM
  Title
An antibiotic factory caught in action.
  Journal
Nat Struct Mol Biol 11:888-93 (2004)
Reference
  Authors
Ridley CP, Lee HY, Khosla C
  Title
Evolution of polyketide synthases in bacteria.
  Journal
Proc Natl Acad Sci U S A 105:4595-600 (2008)
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
Reference
  Authors
Petkovic H, Thamchaipenet A, Zhou LH, Hranueli D, Raspor P, Waterman PG, Hunter IS
  Title
Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths.
  Journal
J Biol Chem 274:32829-34 (1999)
Reference
  Authors
Zhou H, Li Y, Tang Y
  Title
Cyclization of aromatic polyketides from bacteria and fungi.
  Journal
Nat Prod Rep 27:839-68 (2010)
Reference
  Authors
Korman TP, Tan YH, Wong J, Luo R, Tsai SC
  Title
Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase.
  Journal
Biochemistry 47:1837-47 (2008)
Reference
PMID:9375253
  Authors
Kantola J, Blanco G, Hautala A, Kunnari T, Hakala J, Mendez C, Ylihonko K, Mantsala P, Salas J
  Title
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.
  Journal
Chem Biol 4:751-5 (1997)
Reference
  Authors
Kunnari T, Ylihonko K, Hautala A, Klika KD, Mantsala P, Hakala J
  Title
Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants.
  Journal
Bioorg Med Chem Lett 9:2639-42 (1999)
Reference
  Authors
Tsai SC, Ames BD
  Title
Structural enzymology of polyketide synthases.
  Journal
Methods Enzymol 459:17-47 (2009)
Reference
  Authors
Korman TP, Hill JA, Vu TN, Tsai SC
  Title
Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.
  Journal
Biochemistry 43:14529-38 (2004)
Reference
  Authors
Hadfield AT, Limpkin C, Teartasin W, Simpson TJ, Crosby J, Crump MP
  Title
The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding.
  Journal
Structure 12:1865-75 (2004)
Reference
  Authors
Kantola J, Kunnari T, Hautala A, Hakala J, Ylihonko K, Mantsala P
  Title
Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.
  Journal
Microbiology 146 ( Pt 1):155-63 (2000)
Reference
PMID:2394677
  Authors
Bartel PL, Zhu CB, Lampel JS, Dosch DC, Connors NC, Strohl WR, Beale JM Jr, Floss HG
  Title
Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions.
  Journal
J Bacteriol 172:4816-26 (1990)
Reference
  Authors
Arthur CJ, Szafranska AE, Long J, Mills J, Cox RJ, Findlow SC, Simpson TJ, Crump MP, Crosby J
  Title
The malonyl transferase activity of type II polyketide synthase acyl carrier proteins.
  Journal
Chem Biol 13:587-96 (2006)
Reference
  Authors
Schneider G
  Title
Enzymes in the biosynthesis of aromatic polyketide antibiotics.
  Journal
Curr Opin Struct Biol 15:629-36 (2005)
Reference
PMID:1548230
  Authors
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
  Title
Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN  gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.
  Journal
J Bacteriol 174:1810-20 (1992)
Reference
  Authors
Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC
  Title
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides.
  Journal
Proc Natl Acad Sci U S A 105:5349-54 (2008)
Reference
  Authors
Lombo F, Menendez N, Salas JA, Mendez C
  Title
The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives.
  Journal
Appl Microbiol Biotechnol 73:1-14 (2006)
Reference
  Authors
Krohn K (ed).
  Title
Anthracycline Chemistry and Biology I : Biological Occurence and Biosynthesis, Synthesis and Chemistry
  Journal
Topics in Current Chemistry 282 (2008)
KO pathway
 

DBGET integrated database retrieval system