KEGG   PATHWAY: mmu04310Help
Entry
mmu04310                    Pathway                                

Name
Wnt signaling pathway - Mus musculus (mouse)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Wnt signaling pathway
mmu04310

All organismsOrtholog table
Module
SCF-BTRC complex [PATH:mmu04310]
Wnt signaling [PATH:mmu04310]
Other DBs
BSID: 
GO: 
Organism
Mus musculus (mouse) [GN:mmu]
Gene
53627  
Porcn; porcupine homolog (Drosophila) [KO:K00181]
22408  
Wnt1; wingless-type MMTV integration site family, member 1 [KO:K03209]
22413  
Wnt2; wingless-type MMTV integration site family, member 2 [KO:K00182]
22414  
Wnt2b; wingless-type MMTV integration site family, member 2B [KO:K00182]
22415  
Wnt3; wingless-type MMTV integration site family, member 3 [KO:K00312]
22416  
Wnt3a; wingless-type MMTV integration site family, member 3A [KO:K00312]
22417  
Wnt4; wingless-type MMTV integration site family, member 4 [KO:K00408]
22418  
Wnt5a; wingless-type MMTV integration site family, member 5A [KO:K00444]
22419  
Wnt5b; wingless-type MMTV integration site family, member 5B [KO:K00444]
22420  
Wnt6; wingless-type MMTV integration site family, member 6 [KO:K00445]
22421  
Wnt7a; wingless-type MMTV integration site family, member 7A [KO:K00572]
22422  
Wnt7b; wingless-type MMTV integration site family, member 7B [KO:K00572]
20890  
Wnt8a; wingless-type MMTV integration site family, member 8A [KO:K00714]
22423  
Wnt8b; wingless-type MMTV integration site family, member 8B [KO:K00714]
216795  
Wnt9a; wingless-type MMTV integration site family, member 9A [KO:K01064]
22412  
Wnt9b; wingless-type MMTV integration site family, member 9B [KO:K01064]
22410  
Wnt10b; wingless-type MMTV integration site family, member 10B [KO:K01357]
22409  
Wnt10a; wingless-type MMTV integration site family, member 10A [KO:K01357]
22411  
Wnt11; wingless-type MMTV integration site family, member 11 [KO:K01384]
93735  
Wnt16; wingless-type MMTV integration site family, member 16 [KO:K01558]
12622  
Cer1; cerberus 1 homolog (Xenopus laevis) [KO:K01645]
24117  
Wif1; Wnt inhibitory factor 1 [KO:K01691]
74499  
Sost; sclerostin [KO:K16834]
13380  
Dkk1; dickkopf homolog 1 (Xenopus laevis) [KO:K02165]
56811  
Dkk2; dickkopf homolog 2 (Xenopus laevis) [KO:K02165]
234130  
Dkk4; dickkopf homolog 4 (Xenopus laevis) [KO:K02165]
20377  
Sfrp1; secreted frizzled-related protein 1 [KO:K02166]
20319  
Sfrp2; secreted frizzled-related protein 2 [KO:K02176]
20379  
Sfrp4; secreted frizzled-related protein 4 [KO:K02185]
54612  
Sfrp5; secreted frizzled-related sequence protein 5 [KO:K02222]
14362  
Fzd1; frizzled homolog 1 (Drosophila) [KO:K02432]
14369  
Fzd7; frizzled homolog 7 (Drosophila) [KO:K02432]
57265  
Fzd2; frizzled homolog 2 (Drosophila) [KO:K02235]
14365  
Fzd3; frizzled homolog 3 (Drosophila) [KO:K02329]
14366  
Fzd4; frizzled homolog 4 (Drosophila) [KO:K02354]
14367  
Fzd5; frizzled homolog 5 (Drosophila) [KO:K02375]
14370  
Fzd8; frizzled homolog 8 (Drosophila) [KO:K02375]
14368  
Fzd6; frizzled homolog 6 (Drosophila) [KO:K02376]
93897  
Fzd10; frizzled homolog 10 (Drosophila) [KO:K02842]
14371  
Fzd9; frizzled homolog 9 (Drosophila) [KO:K02842]
16973  
Lrp5; low density lipoprotein receptor-related protein 5 [KO:K03068]
16974  
Lrp6; low density lipoprotein receptor-related protein 6 [KO:K03068]
68010  
Bambi; BMP and activin membrane-bound inhibitor [KO:K10162]
27373  
Csnk1e; casein kinase 1, epsilon [KO:K08960] [EC:2.7.11.1]
13544  
Dvl3; dishevelled 3, dsh homolog (Drosophila) [KO:K02353]
13542  
Dvl1; dishevelled, dsh homolog 1 (Drosophila) [KO:K02353]
13543  
Dvl2; dishevelled 2, dsh homolog (Drosophila) [KO:K02353]
14296  
Frat1; frequently rearranged in advanced T cell lymphomas [KO:K03069]
212398  
Frat2; frequently rearranged in advanced T cell lymphomas 2 [KO:K03096]
12995  
Csnk2a1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
13000  
Csnk2a2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
13001  
Csnk2b; casein kinase 2, beta polypeptide [KO:K03115]
93960  
Nkd1; naked cuticle 1 homolog (Drosophila) [KO:K03213]
72293  
Nkd2; naked cuticle 2 homolog (Drosophila) [KO:K03213]
319478  
Cxxc4; CXXC finger 4 [KO:K03344]
75826  
Senp2; SUMO/sentrin specific peptidase 2 [KO:K03345] [EC:3.4.22.68]
114671  
4930444G20Rik; RIKEN cDNA 4930444G20 gene [KO:K03345] [EC:3.4.22.68]
231201  
Susp4; cDNA sequence AF366264 [KO:K03345] [EC:3.4.22.68]
408192  
Gm9839; predicted gene 9839 [KO:K03345] [EC:3.4.22.68]
408191  
Gm5415; predicted gene 5415 [KO:K03345] [EC:3.4.22.68]
56637  
Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
12387  
Ctnnb1; catenin (cadherin associated protein), beta 1 [KO:K02105]
12005  
Axin1; axin 1 [KO:K02157]
12006  
Axin2; axin2 [KO:K04385]
11789  
Apc; adenomatosis polyposis coli [KO:K02085]
23805  
Apc2; adenomatosis polyposis coli 2 [KO:K02085]
93687  
Csnk1a1; casein kinase 1, alpha 1 [KO:K08957] [EC:2.7.11.1]
21414  
Tcf7; transcription factor 7, T cell specific [KO:K02620]
21415  
Tcf7l1; transcription factor 7 like 1 (T cell specific, HMG box) [KO:K04490]
21416  
Tcf7l2; transcription factor 7 like 2, T cell specific, HMG box [KO:K04491]
16842  
Lef1; lymphoid enhancer binding factor 1 [KO:K04492]
67087  
Ctnnbip1; catenin beta interacting protein 1 [KO:K04493]
67772  
Chd8; chromodomain helicase DNA binding protein 8 [KO:K04494] [EC:3.6.4.12]
20671  
Sox17; SRY (sex determining region Y)-box 17 [KO:K04495]
13016  
Ctbp1; C-terminal binding protein 1 [KO:K04496]
13017  
Ctbp2; C-terminal binding protein 2 [KO:K04496]
12914  
Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
328572  
Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
56505  
Ruvbl1; RuvB-like protein 1 [KO:K04499]
17128  
Smad4; SMAD family member 4 [KO:K04501]
26409  
Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
18099  
Nlk; nemo like kinase [KO:K04468] [EC:2.7.11.24]
17869  
Myc; myelocytomatosis oncogene [KO:K04377]
16476  
Jun; jun proto-oncogene [KO:K04448]
14283  
Fosl1; fos-like antigen 1 [KO:K04502]
12443  
Ccnd1; cyclin D1 [KO:K04503]
12444  
Ccnd2; cyclin D2 [KO:K10151]
12445  
Ccnd3; cyclin D3 [KO:K10152]
19015  
Ppard; peroxisome proliferator activator receptor delta [KO:K04504]
17393  
Mmp7; matrix metallopeptidase 7 [KO:K01397] [EC:3.4.24.23]
19164  
Psen1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
18747  
Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  
Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
19108  
Prkx; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
22059  
Trp53; transformation related protein 53 [KO:K04451]
20437  
Siah1a; seven in absentia 1A [KO:K04506] [EC:6.3.2.19]
20438  
Siah1b; seven in absentia 1B [KO:K04506] [EC:6.3.2.19]
12301  
Cacybp; calcyclin binding protein [KO:K04507]
21402  
Skp1a; S-phase kinase-associated protein 1A [KO:K03094]
21372  
Tbl1x; transducin (beta)-like 1 X-linked [KO:K04508]
81004  
Tbl1xr1; transducin (beta)-like 1X-linked receptor 1 [KO:K04508]
103583  
Fbxw11; F-box and WD-40 domain protein 11 [KO:K03362]
12234  
Btrc; beta-transducin repeat containing protein [KO:K03362]
26965  
Cul1; cullin 1 [KO:K03347]
56438  
Rbx1; ring-box 1 [KO:K03868]
Gm9840; predicted gene 9840 [KO:K03868]
14735  
Gpc4; glypican 4 [KO:K08110]
93840  
Vangl2; vang-like 2 (van gogh, Drosophila) [KO:K04510]
229658  
Vangl1; vang-like 1 (van gogh, Drosophila) [KO:K04510]
243548  
Prickle2; prickle homolog 2 (Drosophila) [KO:K04511]
106042  
Prickle1; prickle homolog 1 (Drosophila) [KO:K04511]
208846  
Daam1; dishevelled associated activator of morphogenesis 1 [KO:K04512]
76441  
Daam2; dishevelled associated activator of morphogenesis 2 [KO:K04512]
11848  
Rhoa; ras homolog gene family, member A [KO:K04513]
67653  
4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513]
19878  
Rock2; Rho-associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
19353  
Rac1; RAS-related C3 botulinum substrate 1 [KO:K04392]
19354  
Rac2; RAS-related C3 botulinum substrate 2 [KO:K07860]
170758  
Rac3; RAS-related C3 botulinum substrate 3 [KO:K07861]
26419  
Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  
Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26414  
Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
18795  
Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18797  
Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  
Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
18796  
Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
108058  
Camk2d; calcium/calmodulin-dependent protein kinase II, delta [KO:K04515] [EC:2.7.11.17]
12325  
Camk2g; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
12323  
Camk2b; calcium/calmodulin-dependent protein kinase II, beta [KO:K04515] [EC:2.7.11.17]
12322  
Camk2a; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
19057  
Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19055  
Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  
Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19058  
Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  
Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
18750  
Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
18751  
Prkcb; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
18752  
Prkcg; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
18018  
Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446]
18019  
Nfatc2; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [KO:K17332]
18021  
Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333]
73181  
Nfatc4; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 [KO:K17334]
17127  
Smad3; SMAD family member 3 [KO:K04500]
Compound
C00076  
Calcium cation
Reference
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
Reference
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
Reference
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
Reference
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
Reference
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
Reference
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
Reference
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
Reference
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
Reference
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
Reference
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates  Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
KO pathway
 

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