| Entry |
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| Name |
Other types of O-glycan biosynthesis - Aedes aegypti (yellow fever mosquito)
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| Description |
O-mannosyl glycans are a type of O-glycans that are found both in eukaryotes and prokaryotes. Biosynthesis of O-mannosyl glycans is initiated by the transfer of mannose from Man-P-Dol to serine or threonine residue, which is catalyzed by protein O-mannosyltransferases POMT1 and POMT2. Defects of these genes are linked to human diseases, such as muscular dystrophies caused by reduced O-mannosylation of alpha-dystroglycan in skeletal muscles [DS: H00120].
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| Class |
Metabolism; Glycan biosynthesis and metabolism
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| Pathway map |
| Other types of O-glycan biosynthesis |
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| Organism |
Aedes aegypti (yellow fever mosquito) [GN: aag]
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| Gene |
| mannosyltransferase 1; K00728 dolichyl-phosphate-mannose-protein mannosyltransferase [EC: 2.4.1.109] [KO: K00728] [EC: 2.4.1.109] | | mannosyltransferase 1; K00728 dolichyl-phosphate-mannose-protein mannosyltransferase [EC: 2.4.1.109] [KO: K00728] [EC: 2.4.1.109] | | o-linked n-acetylglucosamine transferase; K09667 polypeptide N-acetylglucosaminyltransferase [EC:2.4.1.-] [KO: K09667] [EC:2.4.1.-] | | | | | | | | galactosyltransferase; K13675 UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase [EC:2.4.1.-] [KO: K13675] [EC:2.4.1.-] | | endoplasmic reticulum-resident kdel protein; K13667 protein glucosyltransferase [EC:2.4.1.-] [KO: K13667] [EC:2.4.1.-] | | hypothetical protein; K13676 UDP-xylose:glucoside alpha-1,3-xylosyltransferase [EC:2.4.2.-] [KO: K13676] [EC:2.4.2.-] | | |
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| Reference |
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| Authors |
Kizuka Y, Oka S |
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| Title |
Regulated expression and neural functions of human natural killer-1 (HNK-1) carbohydrate. |
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| Journal |
Cell Mol Life Sci 69:4135-47 (2012) |
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| Reference |
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| Authors |
Lommel M, Strahl S |
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| Title |
Protein O-mannosylation: conserved from bacteria to humans. |
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| Journal |
Glycobiology 19:816-28 (2009) |
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| KO pathway |
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