KEGG   PATHWAY: aai03440
Entry
aai03440                    Pathway                                
Name
Homologous recombination - Glutamicibacter arilaitensis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
aai03440  Homologous recombination
aai03440

Other DBs
GO: 0000724
Organism
Glutamicibacter arilaitensis [GN:aai]
Gene
AARI_pI00010  single-stranded DNA-binding protein [KO:K03111]
AARI_34010  ssb; single-stranded DNA-binding protein [KO:K03111]
AARI_18650  ssb; single-stranded DNA-binding protein [KO:K03111]
AARI_03700  single-stranded DNA-binding protein [KO:K03111]
AARI_00030  recF; DNA replication and repair protein RecF [KO:K03629]
AARI_16780  recO; DNA repair protein RecO [KO:K03584]
AARI_03170  recR; recombination protein recR [KO:K06187]
AARI_11010  recA; RecA bacterial DNA recombination protein [KO:K03553]
AARI_19350  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
AARI_17470  ruvA; Holliday junction ATP-dependent DNA helicase RuvA [KO:K03550]
AARI_17460  ruvB; Holliday junction ATP-dependent DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
AARI_17480  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
AARI_14440  recG; putative ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
AARI_20640  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
AARI_00020  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
AARI_03180  dnaX; DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
AARI_16950  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
AARI_05190  putative DNA polymerase III subunit delta prime [KO:K02341] [EC:2.7.7.7]
AARI_13030  putative DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
AARI_33870  putative exonuclease [KO:K02342] [EC:2.7.7.7]
AARI_18340  putative DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
AARI_21390  putative DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
AARI_17060  priA; putative primosomal protein PriA [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG GENES (23)   
All databases (24)   

Download RDF
DBGET integrated database retrieval system