KEGG   PATHWAY: aat03440Help
Entry
aat03440                    Pathway                                

Name
Homologous recombination - Aggregatibacter actinomycetemcomitans D11S-1
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
aat03440  Homologous recombination
aat03440

Ortholog table
Other DBs
BSID: 126185
GO: 0000724
Organism
Aggregatibacter actinomycetemcomitans D11S-1 [GN:aat]
Gene
D11S_1084  ssDNA exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
D11S_0456  single-stranded DNA-binding protein [KO:K03111]
D11S_2320  single-strand binding protein [KO:K03111]
D11S_1974  DNA replication protein RecF [KO:K03629]
D11S_0610  recO; DNA repair protein RecO [KO:K03584]
D11S_0821  recR; recombination protein RecR [KO:K06187]
D11S_0271  recombinase RecA [KO:K03553]
D11S_0195  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
D11S_1847  Holliday junction ATP-dependent DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
D11S_1846  ruvB; ATP-dependent DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
D11S_1848  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
D11S_1457  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
D11S_1425  exodeoxyribonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
D11S_1828  exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
D11S_1424  exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
D11S_2123  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
D11S_1973  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
D11S_0463  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
D11S_0023  DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
D11S_1795  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
D11S_1062  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
D11S_1826  DNA polymerase III subunit psi [KO:K02344] [EC:2.7.7.7]
D11S_0426  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
D11S_0390  primosomal replication protein N [KO:K02686]
D11S_1868  primosomal replication protein N [KO:K04067]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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