| Entry |
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| Name |
Lipoic acid metabolism - Acidiphilium cryptum JF-5
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| Class |
Metabolism; Metabolism of cofactors and vitamins
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| Pathway map |
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| Other DBs |
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| Organism |
Acidiphilium cryptum JF-5 [GN: acr]
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| Gene |
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| Compound |
| Lipoate | | Octanoyl-[acp] | | Protein N6-(octanoyl)lysine | | Protein N6-(lipoyl)lysine | | Lipoyl-AMP | | Lipoyl-[acp] |
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| Reference |
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| Authors |
Gunther S, McMillan PJ, Wallace LJ, Muller S. |
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| Title |
Plasmodium falciparum possesses organelle-specific alpha-keto acid dehydrogenase complexes and lipoylation pathways. |
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| Journal |
Biochem Soc Trans 33:977-80 (2005) |
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| Reference |
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| Authors |
Fujiwara K, Suzuki M, Okumachi Y, Okamura-Ikeda K, Fujiwara T, Takahashi E, Motokawa Y. |
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| Title |
Molecular cloning, structural characterization and chromosomal localization of human lipoyltransferase gene. |
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| Journal |
Eur J Biochem 260:761-7 (1999) |
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| Reference |
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| Authors |
Fujiwara K, Okamura-Ikeda K, Motokawa Y. |
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| Title |
Purification and characterization of lipoyl-AMP:N epsilon-lysine lipoyltransferase from bovine liver mitochondria. |
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| Journal |
J Biol Chem 269:16605-9 (1994) |
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| Reference |
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| Authors |
Fujiwara K, Okamura-Ikeda K, Motokawa Y. |
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| Title |
Cloning and expression of a cDNA encoding bovine lipoyltransferase. |
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| Journal |
J Biol Chem 272:31974-8 (1997) |
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| Reference |
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| Authors |
Fujiwara K, Takeuchi S, Okamura-Ikeda K, Motokawa Y. |
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| Title |
Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver. |
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| Journal |
J Biol Chem 276:28819-23 (2001) |
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| Reference |
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| Authors |
Fujiwara K, Toma S, Okamura-Ikeda K, Motokawa Y, Nakagawa A, Taniguchi H. |
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| Title |
Crystal structure of lipoate-protein ligase A from Escherichia coli. Determination of the lipoic acid-binding site. |
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| Journal |
J Biol Chem 280:33645-51 (2005) |
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| Reference |
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| Authors |
Yasuno R, Wada H. |
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| Title |
Biosynthesis of lipoic acid in Arabidopsis: cloning and characterization of the cDNA for lipoic acid synthase. |
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| Journal |
Plant Physiol 118:935-43 (1998) |
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| Reference |
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| Authors |
Gueguen V, Macherel D, Jaquinod M, Douce R, Bourguignon J. |
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| Title |
Fatty acid and lipoic acid biosynthesis in higher plant mitochondria. |
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| Journal |
J Biol Chem 275:5016-25 (2000) |
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| Reference |
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| Authors |
Wada M, Yasuno R, Jordan SW, Cronan JE Jr, Wada H. |
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| Title |
Lipoic acid metabolism in Arabidopsis thaliana: cloning and characterization of a cDNA encoding lipoyltransferase. |
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| Journal |
Plant Cell Physiol 42:650-6 (2001) |
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| Reference |
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| Authors |
Morris TW, Reed KE, Cronan JE Jr. |
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| Title |
Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product. |
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| Journal |
J Biol Chem 269:16091-100 (1994) |
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| Reference |
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| Authors |
Zhao X, Miller JR, Jiang Y, Marletta MA, Cronan JE. |
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| Title |
Assembly of the covalent linkage between lipoic acid and its cognate enzymes. |
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| Journal |
Chem Biol 10:1293-302 (2003) |
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| Reference |
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| Authors |
Nesbitt NM, Baleanu-Gogonea C, Cicchillo RM, Goodson K, Iwig DF, Broadwater JA, Haas JA, Fox BG, Booker SJ. |
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| Title |
Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase. |
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| Journal |
Protein Expr Purif 39:269-82 (2005) |
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| KO pathway |
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