KEGG   PATHWAY: acr00785Help
Entry
acr00785                    Pathway                                

Name
Lipoic acid metabolism - Acidiphilium cryptum
Class
Metabolism; Metabolism of cofactors and vitamins
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Lipoic acid metabolism
acr00785

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BSID: 
GO: 
Organism
Acidiphilium cryptum [GN:acr]
Gene
lipoyl synthase; K03644 lipoic acid synthetase [EC:2.8.1.8] [KO:K03644] [EC:2.8.1.8]
lipB; lipoate-protein ligase B [KO:K03801] [EC:2.3.1.181]
Compound
C00725  
Lipoate
C05752  
Octanoyl-[acp]
C16236  
Protein N6-(octanoyl)lysine
C16237  
Protein N6-(lipoyl)lysine
C16238  
Lipoyl-AMP
C16239  
Lipoyl-[acp]
Reference
  Authors
Gunther S, McMillan PJ, Wallace LJ, Muller S.
  Title
Plasmodium falciparum possesses organelle-specific alpha-keto acid dehydrogenase complexes and lipoylation pathways.
  Journal
Biochem Soc Trans 33:977-80 (2005)
Reference
  Authors
Fujiwara K, Suzuki M, Okumachi Y, Okamura-Ikeda K, Fujiwara T, Takahashi E, Motokawa Y.
  Title
Molecular cloning, structural characterization and chromosomal localization of human lipoyltransferase gene.
  Journal
Eur J Biochem 260:761-7 (1999)
Reference
PMID:8206978
  Authors
Fujiwara K, Okamura-Ikeda K, Motokawa Y.
  Title
Purification and characterization of lipoyl-AMP:N epsilon-lysine lipoyltransferase from bovine liver mitochondria.
  Journal
J Biol Chem 269:16605-9 (1994)
Reference
PMID:9405389
  Authors
Fujiwara K, Okamura-Ikeda K, Motokawa Y.
  Title
Cloning and expression of a cDNA encoding bovine lipoyltransferase.
  Journal
J Biol Chem 272:31974-8 (1997)
Reference
  Authors
Fujiwara K, Takeuchi S, Okamura-Ikeda K, Motokawa Y.
  Title
Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver.
  Journal
J Biol Chem 276:28819-23 (2001)
Reference
  Authors
Fujiwara K, Toma S, Okamura-Ikeda K, Motokawa Y, Nakagawa A, Taniguchi H.
  Title
Crystal structure of lipoate-protein ligase A from Escherichia coli. Determination of the lipoic acid-binding site.
  Journal
J Biol Chem 280:33645-51 (2005)
Reference
PMID:9808738
  Authors
Yasuno R, Wada H.
  Title
Biosynthesis of lipoic acid in Arabidopsis: cloning and characterization of the cDNA for lipoic acid synthase.
  Journal
Plant Physiol 118:935-43 (1998)
Reference
  Authors
Gueguen V, Macherel D, Jaquinod M, Douce R, Bourguignon J.
  Title
Fatty acid and lipoic acid biosynthesis in higher plant mitochondria.
  Journal
J Biol Chem 275:5016-25 (2000)
Reference
  Authors
Wada M, Yasuno R, Jordan SW, Cronan JE Jr, Wada H.
  Title
Lipoic acid metabolism in Arabidopsis thaliana: cloning and characterization of a cDNA encoding lipoyltransferase.
  Journal
Plant Cell Physiol 42:650-6 (2001)
Reference
PMID:8206909
  Authors
Morris TW, Reed KE, Cronan JE Jr.
  Title
Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product.
  Journal
J Biol Chem 269:16091-100 (1994)
Reference
  Authors
Zhao X, Miller JR, Jiang Y, Marletta MA, Cronan JE.
  Title
Assembly of the covalent linkage between lipoic acid and its cognate enzymes.
  Journal
Chem Biol 10:1293-302 (2003)
Reference
  Authors
Nesbitt NM, Baleanu-Gogonea C, Cicchillo RM, Goodson K, Iwig DF, Broadwater JA, Haas JA, Fox BG, Booker SJ.
  Title
Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase.
  Journal
Protein Expr Purif 39:269-82 (2005)
KO pathway
 

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