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ago04113                    Pathway                                

Meiosis - yeast - Ashbya gossypii (Eremothecium gossypii)
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, then segregates from, its homologous pair, while the sister chromatids segregate from each other at meoisis II. In yeast, the switch to enter growth phase or meiosis phase is controlled by nutritional signals. At the onset of meiosis, nutritional signaling pathways converge on transcriptional regulation of Ime1. Ime1 is a transcriptional activator to promote expression of early meiosis-specific genes required for pre-meiotic DNA replication and meiotic recombination. Two of the early meiosis-specific genes, a transcriptional activator, Ndt80, and a CDK2 homolog, Ime2, are required for the transcription of middle meiosis-specific genes, which includes B-type cyclin genes and genes involved in spore wall formation. Polo-like kinase Cdc5, whose expression is activated by Ndt80, is required for the critical step in meiotic progression. Cdc5 regulates sister-kinetochore co-orientation by promoting the localization of Mam1 and Lrs4, components of the co-orientation complex, to kinetochores. Cdc5 also phosphorylates the meiotic cohesin subunit Rec8, which is essential for its cleavage and removal by separase. Moreover, Cdc5 promotes the release of protein phosphatase Cdc14 from the nuclezus, which is required for anaphase I spindle disassembly and exit from meiosis I. The centromeric protein Sgo1 is a key regulator of meiotic chromosome segregation. Sgo1 with PP2A may protect pericentromeric but not arm cohesion of sister chromatids during meiosis I. Sgo1 then disappears at meiosis II to allow sister chromatids to separate.
Cellular Processes; Cell growth and death
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Meiosis - yeast

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Origin recognition complex [PATH:ago04113]
MCM complex [PATH:ago04113]
Other DBs
Ashbya gossypii (Eremothecium gossypii) [GN:ago]
ADR384Wp; K06646 G1/S-specific cyclin CLN3 [KO:K06646]
ADR058Cp; K04563 cyclin-dependent kinase [EC:] [KO:K04563] [EC:]
AGL297Cp; K06649 regulatory protein SWI4 [KO:K06649]
AFR690Cp; K06648 regulatory protein SWI6 [KO:K06648]
AFL174Cp; K06650 G1/S-specific cyclin CLN2 [KO:K06650]
AFL204Cp; K08139 MFS transporter, SP family, sugar:H+ symporter [KO:K08139]
AFL205Cp; K08139 MFS transporter, SP family, sugar:H+ symporter [KO:K08139]
AFL207Cp; K08139 MFS transporter, SP family, sugar:H+ symporter [KO:K08139]
ADR091Wp; K08139 MFS transporter, SP family, sugar:H+ symporter [KO:K08139]
AEL230Wp; K12761 carbon catabolite-derepressing protein kinase [EC:] [KO:K12761] [EC:]
AEL089Cp; K12762 G protein-coupled receptor GPR1 [KO:K12762]
AAL162Cp; K01768 adenylate cyclase [EC:] [KO:K01768] [EC:]
AFL090Wp; K04345 protein kinase A [EC:] [KO:K04345] [EC:]
AEL115Cp; K04345 protein kinase A [EC:] [KO:K04345] [EC:]
ABR089Cp; K09468 zinc finger protein MSN2/4 [KO:K09468]
ABR055Cp; K12763 protein SOK2 [KO:K12763]
AFR076Wp; K12765 meiosis induction protein kinase IME2/SME1 [EC:] [KO:K12765] [EC:]
ABR240Wp; K03085 substrate and inhibitor of the cyclin-dependent protein kinase CDC28 [KO:K03085]
AAR100Cp; K06651 S-phase entry cyclin 5/6 [KO:K06651]
AFR621Cp; K02213 cell division control protein 6 [KO:K02213]
AFR353Wp; K12414 DNA replication licensing factor, required for pre-replication complex assembly [KO:K12414]
AER133Cp; K02603 origin recognition complex subunit 1 [KO:K02603]
AGR028Cp; K02604 origin recognition complex subunit 2 [KO:K02604]
AAL169Cp; K02605 origin recognition complex subunit 3 [KO:K02605]
ABR178Cp; K02606 origin recognition complex subunit 4 [KO:K02606]
AFR656Cp; K02607 origin recognition complex subunit 5 [KO:K02607]
ABR135Cp; K02608 origin recognition complex subunit 6 [KO:K02608]
AFR178Wp; K02540 DNA replication licensing factor MCM2 [EC:] [KO:K02540] [EC:]
AFR355Cp; K02541 DNA replication licensing factor MCM3 [EC:] [KO:K02541] [EC:]
ADL026Wp; K02212 DNA replication licensing factor MCM4 [EC:] [KO:K02212] [EC:]
AGR276Wp; K02209 DNA replication licensing factor MCM5 [EC:] [KO:K02209] [EC:]
AFR546Wp; K02542 DNA replication licensing factor MCM6 [EC:] [KO:K02542] [EC:]
ADR041Wp; K02210 DNA replication licensing factor MCM7 [EC:] [KO:K02210] [EC:]
AGR071Cp; K06628 cell division control protein 45 [KO:K06628]
AER216Cp; K02214 cell division control protein 7 [EC:] [KO:K02214] [EC:]
AGL205Cp; K02309 regulatory subunit for Cdc7p protein kinase [KO:K02309]
ADR253Wp; K12766 serine/threonine-protein kinase MDS1/RIM11 [EC:] [KO:K12766] [EC:]
ACR218Wp; K12767 serine/threonine-protein kinase RIM15 [EC:] [KO:K12767] [EC:]
AGL099Cp; K09243 transcriptional regulatory protein UME6 [KO:K09243]
ADR025Wp; K10878 meiotic recombination protein SPO11 [KO:K10878]
AGR101Cp; K10872 meiotic recombination protein DMC1 [KO:K10872]
AAL085Cp; K12768 synaptonemal complex protein ZIP1 [KO:K12768]
AGR347Wp; K12769 meiosis-specific transcription factor NDT80 [KO:K12769]
ABL089Wp; K12770 GLC7-interacting protein 1 [KO:K12770]
AFR724Cp; K12771 sporulation-specific protein 1 [EC:] [KO:K12771] [EC:]
ABR127Cp; K12772 sporulation-specific protein 4 [KO:K12772]
AFR571Wp; K12773 sporulation-regulated protein 3 [KO:K12773]
ADR068Wp; K06659 G2/mitotic-specific cyclin 3/4 [KO:K06659]
ACL006Wp; K06660 cell cycle serine/threonine-protein kinase CDC5/MSD2 [EC:] [KO:K06660] [EC:]
AGR229Wp; K12575 kinetochore protein SLK19 [KO:K12575]
AEL025Wp; K06639 cell division cycle 14 [EC:] [KO:K06639] [EC:]
AGL304Wp; K12774 monopolin complex subunit MAM1 [KO:K12774]
AER329Cp; K12775 monopolin complex subunit LRS4 [KO:K12775]
AFR166Cp; K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:] [KO:K06269] [EC:]
AER334Cp; K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:] [KO:K06269] [EC:]
AFL051Wp; K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:] [KO:K06269] [EC:]
ADR379Cp; K12776 meiosis-specific serine/threonine-protein kinase MEK1 [EC:] [KO:K12776] [EC:]
AGR260Wp; K12777 protein RED1 [KO:K12777]
ACL029Wp; K12778 meiosis-specific protein HOP1 [KO:K12778]
AAL045Cp; K12779 suppressor of MAR1-1 protein [KO:K12779]
AEL149Cp; K03114 mitosis inhibitor protein kinase SWE1 [EC:] [KO:K03114] [EC:]
AGR289Cp; K02544 G2-specific checkpoint protein [KO:K02544]
AFL075Wp; K06663 DNA damage checkpoint protein [KO:K06663]
ADR411Wp; K02830 cell cycle checkpoint protein [EC:] [KO:K02830] [EC:]
AGR112Cp; K06662 cell cycle checkpoint protein [KO:K06662]
ABR108Cp; K02543 cell cycle checkpoint protein MEC1 [KO:K02543]
AGR173Cp; K06661 DNA repair protein RAD9 [KO:K06661]
ACR142Wp; K02831 ser/thr/tyr protein kinase RAD53 [EC:2.7.11.-] [KO:K02831] [EC:2.7.11.-]
AEL185Cp; K02216 serine/threonine-protein kinase Chk1 [EC:] [KO:K02216] [EC:]
AGR083Wp; K02627 cell cycle regulator [KO:K02627]
AAR089Cp; K02365 separase [EC:] [KO:K02365] [EC:]
AGL023Wp; K06636 structural maintenance of chromosome 1 [KO:K06636]
AAL182Wp; K06669 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) [KO:K06669]
AEL292Wp; K12780 meiotic recombination protein REC8, fungi type [KO:K12780]
ADL093Wp; K06671 cohesin complex subunit SA-1/2 [KO:K06671]
ACR043Wp; K02537 mitotic spindle assembly checkpoint protein MAD2 [KO:K02537]
AFL065Cp; K06679 mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
AFR021Wp; K03348 anaphase-promoting complex subunit 1 [KO:K03348]
AGL193Wp; K03349 anaphase-promoting complex subunit 2 [KO:K03349]
AGL294Wp; K03350 anaphase-promoting complex subunit 3 [KO:K03350]
AGR078Cp; K03351 anaphase-promoting complex subunit 4 [KO:K03351]
AAL094Wp; K03352 anaphase-promoting complex subunit 5 [KO:K03352]
ACR168Wp; K03353 anaphase-promoting complex subunit 6 [KO:K03353]
ABR206Wp; K03355 anaphase-promoting complex subunit 8 [KO:K03355]
AGR070Cp; K03356 anaphase-promoting complex subunit 9 [KO:K03356]
AFR272Wp; K03357 anaphase-promoting complex subunit 10 [KO:K03357]
AER016Cp; K03358 anaphase-promoting complex subunit 11 [KO:K03358]
AEL221Cp; K12416 anaphase-promoting complex subunit SWM1 [KO:K12416]
AFL014Cp; K03363 cell division cycle 20, cofactor of APC complex [KO:K03363]
AGR315Cp; K02178 checkpoint serine/threonine-protein kinase [EC:] [KO:K02178] [EC:]
ADR218Wp; K11582 shugoshin [KO:K11582]
AEL333Wp; K11584 serine/threonine-protein phosphatase 2A regulatory subunit B' [KO:K11584]
ADR099Cp; K04382 serine/threonine-protein phosphatase 2A catalytic subunit [EC:] [KO:K04382] [EC:]
ACR279Cp; K03456 serine/threonine-protein phosphatase 2A regulatory subunit A [KO:K03456]
ADL135Cp; K12782 meiosis-specific APC/C activator protein AMA1 [KO:K12782]
AFR130Wp; K12783 sporulation-specific protein 1 [KO:K12783]
AER223Cp; K06683 cell division control protein CDC15 [EC:] [KO:K06683] [EC:]
3',5'-Cyclic AMP
Honigberg SM, Purnapatre K
Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast.
J Cell Sci 116:2137-47 (2003)
Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G
Transcriptional regulation of meiosis in budding yeast.
Int Rev Cytol 224:111-71 (2003)
Honigberg SM
Ime2p and Cdc28p: co-pilots driving meiotic development.
J Cell Biochem 92:1025-33 (2004)
Hochwagen A, Amon A
Checking your breaks: surveillance mechanisms of meiotic recombination.
Curr Biol 16:R217-28 (2006)
Hollingsworth NM
Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
Genes Dev 22:2596-600 (2008)
Sourirajan A, Lichten M
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
Genes Dev 22:2627-32 (2008)
Roeder GS, Bailis JM
The pachytene checkpoint.
Trends Genet 16:395-403 (2000)
Barr FA, Sillje HH, Nigg EA
Polo-like kinases and the orchestration of cell division.
Nat Rev Mol Cell Biol 5:429-40 (2004)
Lee BH, Amon A
Polo kinase--meiotic cell cycle coordinator.
Cell Cycle 2:400-2 (2003)
Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
Dev Cell 4:727-39 (2003)
Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W
The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
Cell 120:773-88 (2005)
Dai W, Wang X
The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
Cell Div 1:9 (2006)
Clift D, Bizzari F, Marston AL
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
Genes Dev 23:766-80 (2009)
Pesin JA, Orr-Weaver TL
Regulation of APC/C activators in mitosis and meiosis.
Annu Rev Cell Dev Biol 24:475-99 (2008)
Diamond AE, Park JS, Inoue I, Tachikawa H, Neiman AM
The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
Mol Biol Cell 20:134-45 (2009)
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