KEGG   PATHWAY: ago04113Help
Entry
ago04113                    Pathway                                

Name
Meiosis - yeast - Ashbya gossypii (Eremothecium gossypii)
Description
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, then segregates from, its homologous pair, while the sister chromatids segregate from each other at meoisis II. In yeast, the switch to enter growth phase or meiosis phase is controlled by nutritional signals. At the onset of meiosis, nutritional signaling pathways converge on transcriptional regulation of Ime1. Ime1 is a transcriptional activator to promote expression of early meiosis-specific genes required for pre-meiotic DNA replication and meiotic recombination. Two of the early meiosis-specific genes, a transcriptional activator, Ndt80, and a CDK2 homolog, Ime2, are required for the transcription of middle meiosis-specific genes, which includes B-type cyclin genes and genes involved in spore wall formation. Polo-like kinase Cdc5, whose expression is activated by Ndt80, is required for the critical step in meiotic progression. Cdc5 regulates sister-kinetochore co-orientation by promoting the localization of Mam1 and Lrs4, components of the co-orientation complex, to kinetochores. Cdc5 also phosphorylates the meiotic cohesin subunit Rec8, which is essential for its cleavage and removal by separase. Moreover, Cdc5 promotes the release of protein phosphatase Cdc14 from the nuclezus, which is required for anaphase I spindle disassembly and exit from meiosis I. The centromeric protein Sgo1 is a key regulator of meiotic chromosome segregation. Sgo1 with PP2A may protect pericentromeric but not arm cohesion of sister chromatids during meiosis I. Sgo1 then disappears at meiosis II to allow sister chromatids to separate.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
ago04113  Meiosis - yeast
ago04113

Ortholog table
Module
ago_M00284  Origin recognition complex [PATH:ago04113]
ago_M00285  MCM complex [PATH:ago04113]
Other DBs
BSID: 122139
GO: 0051321
Organism
Ashbya gossypii (Eremothecium gossypii) [GN:ago]
Gene
AGOS_ADR384W  ADR384Wp [KO:K06646]
AGOS_ADR058C  ADR058Cp [KO:K04563] [EC:2.7.11.22]
AGOS_AGL297C  AGL297Cp [KO:K06649]
AGOS_AFR690C  AFR690Cp [KO:K06648]
AGOS_AFL174C  AFL174Cp [KO:K06650]
AGOS_AFL204C  AFL204Cp [KO:K08139]
AGOS_AFL205C  AFL205Cp [KO:K08139]
AGOS_AFL207C  AFL207Cp [KO:K08139]
AGOS_ADR091W  ADR091Wp [KO:K08139]
AGOS_AEL230W  AEL230Wp [KO:K12761] [EC:2.7.11.1]
AGOS_AEL089C  AEL089Cp [KO:K12762]
AGOS_AAL162C  AAL162Cp [KO:K01768] [EC:4.6.1.1]
AGOS_AFL090W  AFL090Wp [KO:K04345] [EC:2.7.11.11]
AGOS_AEL115C  AEL115Cp [KO:K04345] [EC:2.7.11.11]
AGOS_ABR089C  ABR089Cp [KO:K09468]
AGOS_ABR055C  ABR055Cp [KO:K12763]
AGOS_AFR076W  AFR076Wp [KO:K12765] [EC:2.7.11.1]
AGOS_ABR240W  ABR240Wp [KO:K03085]
AGOS_AAR100C  AAR100Cp [KO:K06651]
AGOS_AFR621C  AFR621Cp [KO:K02213]
AGOS_AFR353W  AFR353Wp [KO:K12414]
AGOS_AER133C  AER133Cp [KO:K02603]
AGOS_AGR028C  AGR028Cp [KO:K02604]
AGOS_AAL169C  AAL169Cp [KO:K02605]
AGOS_ABR178C  ABR178Cp [KO:K02606]
AGOS_AFR656C  AFR656Cp [KO:K02607]
AGOS_ABR135C  ABR135Cp [KO:K02608]
AGOS_AFR178W  AFR178Wp [KO:K02540] [EC:3.6.4.12]
AGOS_AFR355C  AFR355Cp [KO:K02541] [EC:3.6.4.12]
AGOS_ADL026W  ADL026Wp [KO:K02212] [EC:3.6.4.12]
AGOS_AGR276W  AGR276Wp [KO:K02209] [EC:3.6.4.12]
AGOS_AFR546W  AFR546Wp [KO:K02542] [EC:3.6.4.12]
AGOS_ADR041W  ADR041Wp [KO:K02210] [EC:3.6.4.12]
AGOS_AGR071C  AGR071Cp [KO:K06628]
AGOS_AER216C  AER216Cp [KO:K02214] [EC:2.7.11.1]
AGOS_AGL205C  AGL205Cp [KO:K02309]
AGOS_ADR253W  ADR253Wp [KO:K12766] [EC:2.7.11.1]
AGOS_ACR218W  ACR218Wp [KO:K12767] [EC:2.7.11.1]
AGOS_AGL099C  AGL099Cp [KO:K09243]
AGOS_ADR025W  ADR025Wp [KO:K10878]
AGOS_AGR101C  AGR101Cp [KO:K10872]
AGOS_AAL085C  AAL085Cp [KO:K12768]
AGOS_AGR347W  AGR347Wp [KO:K12769]
AGOS_ABL089W  ABL089Wp [KO:K12770]
AGOS_AFR724C  AFR724Cp [KO:K12771] [EC:2.7.11.1]
AGOS_ABR127C  ABR127Cp [KO:K12772]
AGOS_AFR571W  AFR571Wp [KO:K12773]
AGOS_ADR068W  ADR068Wp [KO:K06659]
AGOS_ACL006W  ACL006Wp [KO:K06660] [EC:2.7.11.21]
AGOS_AGR229W  AGR229Wp [KO:K12575]
AGOS_AEL025W  AEL025Wp [KO:K06639] [EC:3.1.3.48 3.1.3.16]
AGOS_AGL304W  AGL304Wp [KO:K12774]
AGOS_AER329C  AER329Cp [KO:K12775]
AGOS_AFR166C  AFR166Cp [KO:K06269] [EC:3.1.3.16]
AGOS_AER334C  AER334Cp [KO:K06269] [EC:3.1.3.16]
AGOS_AFL051W  AFL051Wp [KO:K06269] [EC:3.1.3.16]
AGOS_ADR379C  ADR379Cp [KO:K12776] [EC:2.7.11.1]
AGOS_AGR260W  AGR260Wp [KO:K12777]
AGOS_ACL029W  ACL029Wp [KO:K12778]
AGOS_AAL045C  AAL045Cp [KO:K12779]
AGOS_AEL149C  AEL149Cp [KO:K03114] [EC:2.7.11.1]
AGOS_AGR289C  AGR289Cp [KO:K02544]
AGOS_AFL075W  AFL075Wp [KO:K06663]
AGOS_ADR411W  ADR411Wp [KO:K02830] [EC:3.1.11.2]
AGOS_AGR112C  AGR112Cp [KO:K06662]
AGOS_ABR108C  ABR108Cp [KO:K02543]
AGOS_AGR173C  AGR173Cp [KO:K06661]
AGOS_ACR142W  ACR142Wp [KO:K02831] [EC:2.7.11.-]
AGOS_AEL185C  AEL185Cp [KO:K02216] [EC:2.7.11.1]
AGOS_AGR083W  AGR083Wp [KO:K02627]
AGOS_AAR089C  AAR089Cp [KO:K02365] [EC:3.4.22.49]
AGOS_AGL023W  AGL023Wp [KO:K06636]
AGOS_AAL182W  AAL182Wp [KO:K06669]
AGOS_AEL292W  AEL292Wp [KO:K12780]
AGOS_ADL093W  ADL093Wp [KO:K06671]
AGOS_ACR043W  ACR043Wp [KO:K02537]
AGOS_AFL065C  AFL065Cp [KO:K06679]
AGOS_AFR021W  AFR021Wp [KO:K03348]
AGOS_AGL193W  AGL193Wp [KO:K03349]
AGOS_AGL294W  AGL294Wp [KO:K03350]
AGOS_AGR078C  AGR078Cp [KO:K03351]
AGOS_AAL094W  AAL094Wp [KO:K03352]
AGOS_ACR168W  ACR168Wp [KO:K03353]
AGOS_ABR206W  ABR206Wp [KO:K03355]
AGOS_AGR070C  AGR070Cp [KO:K03356]
AGOS_AFR272W  AFR272Wp [KO:K03357]
AGOS_AER016C  AER016Cp [KO:K03358]
AGOS_AEL221C  AEL221Cp [KO:K12416]
AGOS_AFL014C  AFL014Cp [KO:K03363]
AGOS_AGR315C  AGR315Cp [KO:K02178] [EC:2.7.11.1]
AGOS_ADR218W  ADR218Wp [KO:K11582]
AGOS_AEL333W  AEL333Wp [KO:K11584]
AGOS_ADR099C  ADR099Cp [KO:K04382] [EC:3.1.3.16]
AGOS_ACR279C  ACR279Cp [KO:K03456]
AGOS_ADL135C  ADL135Cp [KO:K12782]
AGOS_AFR130W  AFR130Wp [KO:K12783]
AGOS_AER223C  AER223Cp [KO:K06683] [EC:2.7.11.1]
Compound
C00031  D-Glucose
C00288  HCO3-
C00575  3',5'-Cyclic AMP
Reference
  Authors
Honigberg SM, Purnapatre K
  Title
Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast.
  Journal
J Cell Sci 116:2137-47 (2003)
DOI:10.1242/jcs.00460
Reference
  Authors
Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G
  Title
Transcriptional regulation of meiosis in budding yeast.
  Journal
Int Rev Cytol 224:111-71 (2003)
DOI:10.1016/S0074-7696(05)24004-4
Reference
  Authors
Honigberg SM
  Title
Ime2p and Cdc28p: co-pilots driving meiotic development.
  Journal
J Cell Biochem 92:1025-33 (2004)
DOI:10.1002/jcb.20131
Reference
  Authors
Hochwagen A, Amon A
  Title
Checking your breaks: surveillance mechanisms of meiotic recombination.
  Journal
Curr Biol 16:R217-28 (2006)
DOI:10.1016/j.cub.2006.03.009
Reference
  Authors
Hollingsworth NM
  Title
Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
  Journal
Genes Dev 22:2596-600 (2008)
DOI:10.1101/gad.1727508
Reference
  Authors
Sourirajan A, Lichten M
  Title
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
  Journal
Genes Dev 22:2627-32 (2008)
DOI:10.1101/gad.1711408
Reference
  Authors
Roeder GS, Bailis JM
  Title
The pachytene checkpoint.
  Journal
Trends Genet 16:395-403 (2000)
DOI:10.1016/S0168-9525(00)02080-1
Reference
  Authors
Barr FA, Sillje HH, Nigg EA
  Title
Polo-like kinases and the orchestration of cell division.
  Journal
Nat Rev Mol Cell Biol 5:429-40 (2004)
DOI:10.1038/nrm1401
Reference
  Authors
Lee BH, Amon A
  Title
Polo kinase--meiotic cell cycle coordinator.
  Journal
Cell Cycle 2:400-2 (2003)
DOI:10.4161/cc.2.5.475
Reference
  Authors
Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K
  Title
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
  Journal
Dev Cell 4:727-39 (2003)
DOI:10.1016/S1534-5807(03)00129-1
Reference
  Authors
Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W
  Title
The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
  Journal
Cell 120:773-88 (2005)
DOI:10.1016/j.cell.2005.01.032
Reference
  Authors
Dai W, Wang X
  Title
The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
  Journal
Cell Div 1:9 (2006)
DOI:10.1186/1747-1028-1-9
Reference
  Authors
Clift D, Bizzari F, Marston AL
  Title
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
  Journal
Genes Dev 23:766-80 (2009)
DOI:10.1101/gad.507509
Reference
  Authors
Pesin JA, Orr-Weaver TL
  Title
Regulation of APC/C activators in mitosis and meiosis.
  Journal
Annu Rev Cell Dev Biol 24:475-99 (2008)
DOI:10.1146/annurev.cellbio.041408.115949
Reference
  Authors
Diamond AE, Park JS, Inoue I, Tachikawa H, Neiman AM
  Title
The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
  Journal
Mol Biol Cell 20:134-45 (2009)
DOI:10.1091/mbc.E08-06-0615
KO pathway
ko04113   

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