KEGG   PATHWAY: ago04113Help
Entry
ago04113                    Pathway                                

Name
Meiosis - yeast - Ashbya gossypii (Eremothecium gossypii)
Description
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, then segregates from, its homologous pair, while the sister chromatids segregate from each other at meoisis II. In yeast, the switch to enter growth phase or meiosis phase is controlled by nutritional signals. At the onset of meiosis, nutritional signaling pathways converge on transcriptional regulation of Ime1. Ime1 is a transcriptional activator to promote expression of early meiosis-specific genes required for pre-meiotic DNA replication and meiotic recombination. Two of the early meiosis-specific genes, a transcriptional activator, Ndt80, and a CDK2 homolog, Ime2, are required for the transcription of middle meiosis-specific genes, which includes B-type cyclin genes and genes involved in spore wall formation. Polo-like kinase Cdc5, whose expression is activated by Ndt80, is required for the critical step in meiotic progression. Cdc5 regulates sister-kinetochore co-orientation by promoting the localization of Mam1 and Lrs4, components of the co-orientation complex, to kinetochores. Cdc5 also phosphorylates the meiotic cohesin subunit Rec8, which is essential for its cleavage and removal by separase. Moreover, Cdc5 promotes the release of protein phosphatase Cdc14 from the nuclezus, which is required for anaphase I spindle disassembly and exit from meiosis I. The centromeric protein Sgo1 is a key regulator of meiotic chromosome segregation. Sgo1 with PP2A may protect pericentromeric but not arm cohesion of sister chromatids during meiosis I. Sgo1 then disappears at meiosis II to allow sister chromatids to separate.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
Meiosis - yeast
ago04113

All organismsOrtholog table
Module
Origin recognition complex [PATH:ago04113]
MCM complex [PATH:ago04113]
Other DBs
BSID: 
GO: 
Organism
Ashbya gossypii (Eremothecium gossypii) [GN:ago]
Gene
ADR384Wp [KO:K06646]
ADR058Cp [KO:K04563] [EC:2.7.11.22]
AGL297Cp [KO:K06649]
AFR690Cp [KO:K06648]
AFL174Cp [KO:K06650]
AFL204Cp [KO:K08139]
AFL205Cp [KO:K08139]
AFL207Cp [KO:K08139]
ADR091Wp [KO:K08139]
AEL230Wp [KO:K12761] [EC:2.7.11.1]
AEL089Cp [KO:K12762]
AAL162Cp [KO:K01768] [EC:4.6.1.1]
AFL090Wp [KO:K04345] [EC:2.7.11.11]
AEL115Cp [KO:K04345] [EC:2.7.11.11]
ABR089Cp [KO:K09468]
ABR055Cp [KO:K12763]
AFR076Wp [KO:K12765] [EC:2.7.11.1]
ABR240Wp [KO:K03085]
AAR100Cp [KO:K06651]
AFR621Cp [KO:K02213]
AFR353Wp [KO:K12414]
AER133Cp [KO:K02603]
AGR028Cp [KO:K02604]
AAL169Cp [KO:K02605]
ABR178Cp [KO:K02606]
AFR656Cp [KO:K02607]
ABR135Cp [KO:K02608]
AFR178Wp [KO:K02540] [EC:3.6.4.12]
AFR355Cp [KO:K02541] [EC:3.6.4.12]
ADL026Wp [KO:K02212] [EC:3.6.4.12]
AGR276Wp [KO:K02209] [EC:3.6.4.12]
AFR546Wp [KO:K02542] [EC:3.6.4.12]
ADR041Wp [KO:K02210] [EC:3.6.4.12]
AGR071Cp [KO:K06628]
AER216Cp [KO:K02214] [EC:2.7.11.1]
AGL205Cp [KO:K02309]
ADR253Wp [KO:K12766] [EC:2.7.11.1]
ACR218Wp [KO:K12767] [EC:2.7.11.1]
AGL099Cp [KO:K09243]
ADR025Wp [KO:K10878]
AGR101Cp [KO:K10872]
AAL085Cp [KO:K12768]
AGR347Wp [KO:K12769]
ABL089Wp [KO:K12770]
AFR724Cp [KO:K12771] [EC:2.7.11.1]
ABR127Cp [KO:K12772]
AFR571Wp [KO:K12773]
ADR068Wp [KO:K06659]
ACL006Wp [KO:K06660] [EC:2.7.11.21]
AGR229Wp [KO:K12575]
AEL025Wp [KO:K06639] [EC:3.1.3.48 3.1.3.16]
AGL304Wp [KO:K12774]
AER329Cp [KO:K12775]
AFR166Cp [KO:K06269] [EC:3.1.3.16]
AER334Cp [KO:K06269] [EC:3.1.3.16]
AFL051Wp [KO:K06269] [EC:3.1.3.16]
ADR379Cp [KO:K12776] [EC:2.7.11.1]
AGR260Wp [KO:K12777]
ACL029Wp [KO:K12778]
AAL045Cp [KO:K12779]
AEL149Cp [KO:K03114] [EC:2.7.11.1]
AGR289Cp [KO:K02544]
AFL075Wp [KO:K06663]
ADR411Wp [KO:K02830] [EC:3.1.11.2]
AGR112Cp [KO:K06662]
ABR108Cp [KO:K02543]
AGR173Cp [KO:K06661]
ACR142Wp [KO:K02831] [EC:2.7.11.-]
AEL185Cp [KO:K02216] [EC:2.7.11.1]
AGR083Wp [KO:K02627]
AAR089Cp [KO:K02365] [EC:3.4.22.49]
AGL023Wp [KO:K06636]
AAL182Wp [KO:K06669]
AEL292Wp [KO:K12780]
ADL093Wp [KO:K06671]
ACR043Wp [KO:K02537]
AFL065Cp [KO:K06679]
AFR021Wp [KO:K03348]
AGL193Wp [KO:K03349]
AGL294Wp [KO:K03350]
AGR078Cp [KO:K03351]
AAL094Wp [KO:K03352]
ACR168Wp [KO:K03353]
ABR206Wp [KO:K03355]
AGR070Cp [KO:K03356]
AFR272Wp [KO:K03357]
AER016Cp [KO:K03358]
AEL221Cp [KO:K12416]
AFL014Cp [KO:K03363]
AGR315Cp [KO:K02178] [EC:2.7.11.1]
ADR218Wp [KO:K11582]
AEL333Wp [KO:K11584]
ADR099Cp [KO:K04382] [EC:3.1.3.16]
ACR279Cp [KO:K03456]
ADL135Cp [KO:K12782]
AFR130Wp [KO:K12783]
AER223Cp [KO:K06683] [EC:2.7.11.1]
Compound
C00031  
D-Glucose
C00288  
HCO3-
C00575  
3',5'-Cyclic AMP
Reference
  Authors
Honigberg SM, Purnapatre K
  Title
Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast.
  Journal
J Cell Sci 116:2137-47 (2003)
DOI:10.1242/jcs.00460
Reference
  Authors
Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G
  Title
Transcriptional regulation of meiosis in budding yeast.
  Journal
Int Rev Cytol 224:111-71 (2003)
DOI:10.1016/S0074-7696(05)24004-4
Reference
  Authors
Honigberg SM
  Title
Ime2p and Cdc28p: co-pilots driving meiotic development.
  Journal
J Cell Biochem 92:1025-33 (2004)
DOI:10.1002/jcb.20131
Reference
  Authors
Hochwagen A, Amon A
  Title
Checking your breaks: surveillance mechanisms of meiotic recombination.
  Journal
Curr Biol 16:R217-28 (2006)
DOI:10.1016/j.cub.2006.03.009
Reference
  Authors
Hollingsworth NM
  Title
Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
  Journal
Genes Dev 22:2596-600 (2008)
DOI:10.1101/gad.1727508
Reference
  Authors
Sourirajan A, Lichten M
  Title
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
  Journal
Genes Dev 22:2627-32 (2008)
DOI:10.1101/gad.1711408
Reference
  Authors
Roeder GS, Bailis JM
  Title
The pachytene checkpoint.
  Journal
Trends Genet 16:395-403 (2000)
DOI:10.1016/S0168-9525(00)02080-1
Reference
  Authors
Barr FA, Sillje HH, Nigg EA
  Title
Polo-like kinases and the orchestration of cell division.
  Journal
Nat Rev Mol Cell Biol 5:429-40 (2004)
DOI:10.1038/nrm1401
Reference
  Authors
Lee BH, Amon A
  Title
Polo kinase--meiotic cell cycle coordinator.
  Journal
Cell Cycle 2:400-2 (2003)
DOI:10.4161/cc.2.5.475
Reference
  Authors
Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K
  Title
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
  Journal
Dev Cell 4:727-39 (2003)
DOI:10.1016/S1534-5807(03)00129-1
Reference
  Authors
Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W
  Title
The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
  Journal
Cell 120:773-88 (2005)
DOI:10.1016/j.cell.2005.01.032
Reference
  Authors
Dai W, Wang X
  Title
The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
  Journal
Cell Div 1:9 (2006)
DOI:10.1186/1747-1028-1-9
Reference
  Authors
Clift D, Bizzari F, Marston AL
  Title
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
  Journal
Genes Dev 23:766-80 (2009)
DOI:10.1101/gad.507509
Reference
  Authors
Pesin JA, Orr-Weaver TL
  Title
Regulation of APC/C activators in mitosis and meiosis.
  Journal
Annu Rev Cell Dev Biol 24:475-99 (2008)
DOI:10.1146/annurev.cellbio.041408.115949
Reference
  Authors
Diamond AE, Park JS, Inoue I, Tachikawa H, Neiman AM
  Title
The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
  Journal
Mol Biol Cell 20:134-45 (2009)
DOI:10.1091/mbc.E08-06-0615
KO pathway
 

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