| Entry |
|
|---|
| Name |
Homologous recombination - Ajellomyces capsulatus
|
|---|
| Description |
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
|
|---|
| Class |
Genetic Information Processing; Replication and repair
 |
|---|
| Pathway map |
  |
|---|
| Module |
| DNA polymerase III complex, bacteria [PATH: aje03440] | | | | | | | | BRCA1-associated genome surveillance complex (BASC) [PATH: aje03440] |
|
|---|
| Other DBs |
|
|---|
| Organism |
Ajellomyces capsulatus [GN: aje]
|
|---|
| Gene |
| hypothetical protein; K10866 DNA repair protein RAD50 [EC:3.6.-.-] [KO: K10866] [EC:3.6.-.-] | | double-strand break repair protein mus-23; K10865 double-strand break repair protein MRE11 [KO: K10865] | | hypothetical protein; K10958 DNA repair protein RAD57 [KO: K10958] | | hypothetical protein; K07466 replication factor A1 [KO: K07466] | | hypothetical protein; K10739 replication factor A2 [KO: K10739] | | DNA repair protein RAD51; K04482 DNA repair protein RAD51 [KO: K04482] | | hypothetical protein; K10873 DNA repair and recombination protein RAD52 [KO: K10873] | | hypothetical protein; K10881 26 proteasome complex subunit DSS1 [KO: K10881] | | DNA repair and recombination protein RAD54; K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] [KO: K10875] [EC:3.6.4.-] | | hypothetical protein; K10877 DNA repair and recombination protein RAD54B [EC:3.6.4.-] [KO: K10877] [EC:3.6.4.-] | | DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1 [EC: 2.7.7.7] [KO: K02327] [EC: 2.7.7.7] | | hypothetical protein; K02328 DNA polymerase delta subunit 2 [KO: K02328] | | hypothetical protein; K03504 DNA polymerase delta subunit 3 [KO: K03504] | | hypothetical protein; K03505 DNA polymerase delta subunit 4 [KO: K03505] | | | | | | | | hypothetical protein; K08991 crossover junction endonuclease MUS81 [EC:3.1.22.-] [KO: K08991] [EC:3.1.22.-] | | hypothetical protein; K10882 crossover junction endonuclease EME1 [EC:3.1.22.-] [KO: K10882] [EC:3.1.22.-] |
|
|---|
| Reference |
|
|---|
| Authors |
Maloisel L, Fabre F, Gangloff S. |
|---|
| Title |
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension. |
|---|
| Journal |
Mol Cell Biol 28:1373-82 (2008) |
|---|
| Reference |
|
|---|
| Authors |
Haruta-Takahashi N, Iwasaki H. |
|---|
| Title |
[Recombination mediators] Japanese |
|---|
| Journal |
Seikagaku 79:449-53 (2007) |
|---|
| Reference |
|
|---|
| Authors |
Ouyang KJ, Woo LL, Ellis NA. |
|---|
| Title |
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases. |
|---|
| Journal |
Mech Ageing Dev 129:425-40 (2008) |
|---|
| Reference |
|
|---|
| Authors |
Kawabata M, Kawabata T, Nishibori M. |
|---|
| Title |
Role of recA/RAD51 family proteins in mammals. |
|---|
| Journal |
Acta Med Okayama 59:1-9 (2005) |
|---|
| Reference |
|
|---|
| Authors |
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A. |
|---|
| Title |
Mitotic recombination in Saccharomyces cerevisiae. |
|---|
| Journal |
Curr Genet 42:185-98 (2003) |
|---|
| Reference |
|
|---|
| Authors |
Heyer WD, Li X, Rolfsmeier M, Zhang XP. |
|---|
| Title |
Rad54: the Swiss Army knife of homologous recombination? |
|---|
| Journal |
Nucleic Acids Res 34:4115-25 (2006) |
|---|
| Reference |
|
|---|
| Authors |
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R. |
|---|
| Title |
Recombination proteins and rescue of arrested replication forks. |
|---|
| Journal |
DNA Repair (Amst) 6:967-80 (2007) |
|---|
| Reference |
|
|---|
| Authors |
Hanaoka F. |
|---|
| Title |
[DNA Replication and Repair] (In Japanese) |
|---|
| Journal |
Yodosha (2004) |
|---|
| Reference |
|
|---|
| Authors |
Ohashi E, Ohmori H. |
|---|
| Title |
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese) |
|---|
| Journal |
Cell Technology 19:1449-53 (2000) |
|---|
| KO pathway |
|
|---|
