KEGG   PATHWAY: amb03440
Entry
amb03440                    Pathway                                
Name
Homologous recombination - Alteromonas macleodii Balearic Sea AD45
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
amb03440  Homologous recombination
amb03440

Other DBs
GO: 0000724
Organism
Alteromonas macleodii Balearic Sea AD45 [GN:amb]
Gene
AMBAS45_03470  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
AMBAS45_00940  single-strand binding protein [KO:K03111]
AMBAS45_00015  recombinational DNA repair ATPase [KO:K03629]
AMBAS45_03480  DNA repair protein RecO [KO:K03584]
AMBAS45_12745  recombination protein RecR [KO:K06187]
AMBAS45_04480  recombinase A [KO:K03553]
AMBAS45_00085  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
AMBAS45_06275  Holliday junction DNA helicase motor protein [KO:K03550]
AMBAS45_06280  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
AMBAS45_06270  Holliday junction resolvase [KO:K01159] [EC:3.1.21.10]
AMBAS45_00570  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
AMBAS45_19705  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
AMBAS45_11570  exodeoxyribonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
AMBAS45_11575  exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
AMBAS45_11565  exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
AMBAS45_04775  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
AMBAS45_00010  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
AMBAS45_12770  DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
AMBAS45_09215  putative DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
AMBAS45_08525  DNA polymerase III subunit delta [KO:K02341] [EC:2.7.7.7]
AMBAS45_08330  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
AMBAS45_19040  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
AMBAS45_16845  putative DNA polymerase [KO:K02342] [EC:2.7.7.7]
AMBAS45_15645  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
AMBAS45_17590  primosome assembly protein PriA [KO:K04066] [EC:5.6.2.4]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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