KEGG   PATHWAY: amg03440
Entry
amg03440                    Pathway                                
Name
Homologous recombination - Alteromonas macleodii English Channel 673
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
amg03440  Homologous recombination
amg03440

Other DBs
GO: 0000724
Organism
Alteromonas macleodii English Channel 673 [GN:amg]
Gene
AMEC673_03425  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
AMEC673_00955  single-strand binding protein [KO:K03111]
AMEC673_00015  recombinational DNA repair ATPase [KO:K03629]
AMEC673_03435  DNA repair protein RecO [KO:K03584]
AMEC673_04330  recombinase A [KO:K03553]
AMEC673_00080  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
AMEC673_06120  Holliday junction DNA helicase motor protein [KO:K03550]
AMEC673_06125  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
AMEC673_06115  Holliday junction resolvase [KO:K01159] [EC:3.1.21.10]
AMEC673_00580  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
AMEC673_11295  exodeoxyribonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
AMEC673_11300  exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
AMEC673_11290  exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
AMEC673_04630  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
AMEC673_00010  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
AMEC673_12535  DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
AMEC673_08695  putative DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
AMEC673_08030  DNA polymerase III subunit delta [KO:K02341] [EC:2.7.7.7]
AMEC673_16620  putative DNA polymerase [KO:K02342] [EC:2.7.7.7]
AMEC673_18805  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
AMEC673_07835  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
AMEC673_15390  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
AMEC673_17320  primosome assembly protein PriA [KO:K04066] [EC:5.6.2.4]
AMEC673_19555  flavodoxin [KO:K02317]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG GENES (24)   
All databases (25)   

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