KEGG PATHWAY: aml04722

PATHWAY: aml04722

Entry

aml04722 Pathway

Name

Neurotrophin signaling pathway - Ailuropoda melanoleuca (giant panda)

Description

Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.

Class

Organismal Systems; Nervous system

Pathway map

aml04722

Neurotrophin signaling pathway

Organism

Ailuropoda melanoleuca (giant panda) [GN:aml]

Gene

100469695	beta-nerve growth factor-like; K02582 nerve growth factor, beta [KO:K02582]
100475465	neurotrophin-4-like; K12457 neurotrophin 4 [KO:K12457]
100474326	neurotrophin-3-like; K04356 neurotrophin 3 [KO:K04356]
100474165	NTRK1; neurotrophic tyrosine kinase, receptor, type 1 [KO:K03176] [EC:2.7.10.1]
100477127	NTRK2; neurotrophic tyrosine kinase, receptor, type 2 [KO:K04360] [EC:2.7.10.1]
100472259	NTRK3; neurotrophic tyrosine kinase, receptor, type 3 [KO:K05101] [EC:2.7.10.1]
100470297	SH2B1; SH2B adaptor protein 1 [KO:K12459]
100475295	SH2B adapter protein 3-like; K12459 SH2B adaptor protein 1/3 [KO:K12459]
100468916	growth factor receptor-bound protein 2-like; K04364 growth factor receptor-binding protein 2 [KO:K04364]
100474396	SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
100482526	SOS1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
100473836	GTPase HRas-like; K02833 GTPase HRas [KO:K02833]
100483919	GTPase KRas-like; K07827 GTPase KRas [KO:K07827]
100464196	GTPase NRas-like; K07828 GTPase NRas [KO:K07828]
100482255	RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [KO:K04366] [EC:2.7.11.1]
100469346	BRAF; v-raf murine sarcoma viral oncogene homolog B1 [KO:K04365] [EC:2.7.11.1]
100478039	MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100465700	dual specificity mitogen-activated protein kinase kinase 2-like; K04369 mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] [KO:K04369] [EC:2.7.12.2]
100472388	mitogen-activated protein kinase 3-like; K04371 extracellular signal-regulated kinase 1/2 [EC:2.7.11.24] [KO:K04371] [EC:2.7.11.24]
100470035	mitogen-activated protein kinase 1-like; K04371 extracellular signal-regulated kinase 1/2 [EC:2.7.11.24] [KO:K04371] [EC:2.7.11.24]
100470572	ribosomal protein S6 kinase alpha-3-like; K04373 p90 ribosomal S6 kinase [EC:2.7.11.1] [KO:K04373] [EC:2.7.11.1]
100474764	RPS6KA6; ribosomal protein S6 kinase, 90kDa, polypeptide 6 [KO:K04373] [EC:2.7.11.1]
100483843	ribosomal protein S6 kinase alpha-2-like; K04373 p90 ribosomal S6 kinase [EC:2.7.11.1] [KO:K04373] [EC:2.7.11.1]
100464040	RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1 [KO:K04373] [EC:2.7.11.1]
100482684	ribosomal protein S6 kinase alpha-5-like; K04445 ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1] [KO:K04445] [EC:2.7.11.1]
100476284	cyclic AMP-dependent transcription factor ATF-4-like; K04374 cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100484344	apoptosis regulator Bcl-2-like; K02161 apoptosis regulator BCL-2 [KO:K02161]
100483274	KIDINS220; kinase D-interacting substrate, 220kDa [KO:K12460]
100483017	FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
100466609	crk-like protein-like; K04438 proto-oncogene C-crk [KO:K04438]
100467322	adapter molecule crk-like; K04438 proto-oncogene C-crk [KO:K04438]
100478465	rap guanine nucleotide exchange factor 1-like; K06277 Rap guanine nucleotide exchange factor (GEF) 1 [KO:K06277]
100471801	ras-related protein Rap-1A-like; K04353 Ras-related protein Rap-1A [KO:K04353]
100480240	ras-related protein Rap-1b-like; K07836 Ras-related protein Rap-1B [KO:K07836]
100475740	mitogen-activated protein kinase kinase kinase 3-like; K04421 mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25] [KO:K04421] [EC:2.7.11.25]
100468286	MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
100470193	mitogen-activated protein kinase 7-like; K04464 mitogen-activated protein kinase 7 [EC:2.7.11.24] [KO:K04464] [EC:2.7.11.24]
100465223	mitogen-activated protein kinase 13-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
100465476	mitogen-activated protein kinase 14-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
100480235	mitogen-activated protein kinase 12-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
100480483	mitogen-activated protein kinase 11-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
100483931	MAP kinase-activated protein kinase 2-like; K04443 mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1] [KO:K04443] [EC:2.7.11.1]
100475137	SHC4; SHC (Src homology 2 domain containing) family, member 4 [KO:K06279]
100468080	SHC3; SHC (Src homology 2 domain containing) transforming protein 3 [KO:K06279]
100480694	SHC2; SHC (Src homology 2 domain containing) transforming protein 2 [KO:K06279]
100480856	SHC1; SHC (Src homology 2 domain containing) transforming protein 1 [KO:K06279]
100472197	GRB2-associated-binding protein 1-like; K09593 GRB2-associated-binding protein 1 [KO:K09593]
100475291	phosphatidylinositol 3-kinase regulatory subunit beta-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
100483828	phosphatidylinositol 3-kinase regulatory subunit alpha-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
100477067	phosphoinositide 3-kinase regulatory subunit 5-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
100467916	phosphatidylinositol 3-kinase regulatory subunit gamma-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
100470322	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100463775	PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100479294	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100479580	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100468763	AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
100480414	AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
100465793	RAC-alpha serine/threonine-protein kinase-like; K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] [KO:K04456] [EC:2.7.11.1]
100466767	NF-kappa-B inhibitor beta-like; K02581 NF-kappa-B inhibitor beta [KO:K02581]
100466997	NF-kappa-B inhibitor alpha-like; K04734 NF-kappa-B inhibitor alpha [KO:K04734]
100481976	NF-kappa-B inhibitor epsilon-like; K05872 NF-kappa-B inhibitor epsilon [KO:K05872]
100467906	NFKB; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
100480158	transcription factor p65-like; K04735 transcription factor p65 [KO:K04735]
100480992	forkhead box protein O3-like; K09408 forkhead box protein O3 [KO:K09408]
100468235	tumor necrosis factor ligand superfamily member 6-like; K04389 tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100473937	bcl2 antagonist of cell death-like; K02158 BCL2-antagonist of cell death [KO:K02158]
100479224	GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
100483652	pyruvate dehydrogenase [lipoamide] kinase isozyme 1-like; K12077 pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2] [KO:K12077] [EC:2.7.11.2]
100480586	1-phosphatidylinositol-4; K01116 phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11] [KO:K01116] [EC:3.1.4.11]
100481994	PLCG2; phospholipase C, gamma 2 (phosphatidylinositol-specific) [KO:K05859] [EC:3.1.4.11]
100478600	calmodulin-like protein 6-like; K02183 calmodulin [KO:K02183]
100470909	calmodulin-like; K02183 calmodulin [KO:K02183]
100484519	calmodulin-like; K02183 calmodulin [KO:K02183]
100484770	calmodulin-like protein 3-like; K02183 calmodulin [KO:K02183]
100481177	calmodulin-like; K02183 calmodulin [KO:K02183]
100472122	calmodulin-like; K02183 calmodulin [KO:K02183]
100475467	calcium/calmodulin-dependent protein kinase type II subunit alpha-like; K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] [KO:K04515] [EC:2.7.11.17]
100466256	calcium/calmodulin-dependent protein kinase type II subunit delta-like; K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] [KO:K04515] [EC:2.7.11.17]
100474459	calcium/calmodulin-dependent protein kinase type II subunit gamma-like; K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] [KO:K04515] [EC:2.7.11.17]
100473015	CAMK4; calcium/calmodulin-dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
100466468	ABL1; c-abl oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
100468867	PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
100477232	MATK; megakaryocyte-associated tyrosine kinase [KO:K08888] [EC:2.7.10.2]
100478241	tumor necrosis factor receptor superfamily member 16-like; K02583 nerve growth factor receptor (TNFR superfamily member 16) [KO:K02583]
100479542	rho GDP-dissociation inhibitor 1-like; K12462 Rho GDP-dissociation inhibitor [KO:K12462]
100480962	rho GDP-dissociation inhibitor 2-like; K12462 Rho GDP-dissociation inhibitor [KO:K12462]
100481000	rho GDP-dissociation inhibitor 3-like; K12462 Rho GDP-dissociation inhibitor [KO:K12462]
100476723	transforming protein RhoA-like; K04513 Ras homolog gene family, member A [KO:K04513]
100465076	cell division control protein 42 homolog; K04393 cell division control protein 42 [KO:K04393]
100466442	MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
100475304	MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100475975	dual specificity mitogen-activated protein kinase kinase 7-like; K04431 mitogen-activated protein kinase kinase 7 [EC:2.7.12.2] [KO:K04431] [EC:2.7.12.2]
100477951	MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100482196	MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
100477600	MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100483834	transcription factor AP-1-like; K04448 transcription factor AP-1 [KO:K04448]
100468516	cellular tumor antigen p53-like; K04451 tumor protein p53 [KO:K04451]
100471095	apoptosis regulator BAX-like; K02159 apoptosis regulator BAX [KO:K02159]
100480840	tumor protein p73-like; K10148 tumor protein p73 [KO:K10148]
100483216	TNF receptor-associated factor 6-like; K03175 TNF receptor-associated factor 6 [KO:K03175]
100482125	ZNF274; zinc finger protein 274 [KO:K12458]
100467671	PR domain zinc finger protein 4-like; K12463 PR domain zinc finger protein 4 [KO:K12463]
100479784	MAGED1; melanoma antigen family D, 1 [KO:K12464]
100469953	protein BEX3-like; K12465 nerve growth factor receptor-associated protein 1 [KO:K12465]
100484851	14-3-3 protein epsilon-like; K06630 14-3-3 protein epsilon [KO:K06630]
100480506	RIPK2; receptor-interacting serine-threonine kinase 2 [KO:K08846] [EC:2.7.11.1]
100484977	interleukin-1 receptor-associated kinase 1-like; K04730 interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1] [KO:K04730] [EC:2.7.11.1]
100468615	interleukin-1 receptor-associated kinase-like 2-like; K04731 interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1] [KO:K04731] [EC:2.7.11.1]
100483119	IRAK3; interleukin-1 receptor-associated kinase 3 [KO:K04732] [EC:2.7.11.1]
100469127	IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100471679	IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
100465908	SORT1; sortilin 1 [KO:K12388]
100477956	presenilin-1-like; K04505 presenilin 1 [EC:3.4.23.-] [KO:K04505] [EC:3.4.23.-]
100466510	presenilin-2-like; K04522 presenilin 2 [EC:3.4.23.-] [KO:K04522] [EC:3.4.23.-]

Compound

C00076	Calcium cation
C00165	Diacylglycerol
C00195	N-Acylsphingosine
C01245	D-myo-Inositol 1,4,5-trisphosphate
C05981	Phosphatidylinositol-3,4,5-trisphosphate

Reference

PMID:12676795

Authors

Huang EJ, Reichardt LF.

Title

Trk receptors: roles in neuronal signal transduction.

Journal

Annu Rev Biochem 72:609-42 (2003)

Reference

PMID:11399424

Authors

Patapoutian A, Reichardt LF

Title

Trk receptors: mediators of neurotrophin action.

Journal

Curr Opin Neurobiol 11:272-80 (2001)

Reference

PMID:16699811

Authors

Arevalo JC, Wu SH

Title

Neurotrophin signaling: many exciting surprises!

Journal

Cell Mol Life Sci 63:1523-37 (2006)

Reference

PMID:14704852

Authors

Teng KK, Hempstead BL

Title

Neurotrophins and their receptors: signaling trios in complex biological systems.

Journal

Cell Mol Life Sci 61:35-48 (2004)

Reference

PMID:11529497

Authors

Miller FD, Kaplan DR

Title

Neurotrophin signalling pathways regulating neuronal apoptosis.

Journal

Cell Mol Life Sci 58:1045-53 (2001)

Reference

PMID:10851172

Authors

Kaplan DR, Miller FD

Title

Neurotrophin signal transduction in the nervous system.

Journal

Curr Opin Neurobiol 10:381-91 (2000)

Reference

PMID:16939974

Authors

Reichardt LF

Title

Neurotrophin-regulated signalling pathways.

Journal

Philos Trans R Soc Lond B Biol Sci 361:1545-64 (2006)

Reference

PMID:16856873

Authors

Zampieri N, Chao MV

Title

Mechanisms of neurotrophin receptor signalling.

Journal

Biochem Soc Trans 34:607-11 (2006)

Reference

PMID:15499580

Authors

Rose CR, Blum R, Kafitz KW, Kovalchuk Y, Konnerth A

Title

From modulator to mediator: rapid effects of BDNF on ion channels.

Journal

Bioessays 26:1185-94 (2004)

Reference

PMID:10812966

Authors

Yano H, Chao MV

Title

Neurotrophin receptor structure and interactions.

Journal

Pharm Acta Helv 74:253-60 (2000)

Reference

PMID:10764727

Authors

Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA

Title

NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.

Journal

J Biol Chem 275:17566-70 (2000)

Reference

PMID:10985348

Authors

Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, Verdi JM, Barker PA

Title

NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.

Journal

Neuron 27:279-88 (2000)

KO pathway

ko04722

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (114)   
   KEGG GENES (114)   
All databases (116)   

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