| Entry |
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| Name |
Base excision repair - Aeropyrum pernix
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| Description |
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
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| Class |
Genetic Information Processing; Replication and repair
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| Pathway map |
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| Module |
| DNA polymerase delta complex [PATH: ape03410] | | |
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| Other DBs |
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| Organism |
Aeropyrum pernix [GN: ape]
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| Gene |
| | | | | U/G and T/G mismatch-specific DNA glycosylase; K03575 A/G-specific adenine glycosylase [EC:3.2.2.-] [KO: K03575] [EC:3.2.2.-] | | 3-methyladenine DNA glycosylase; K03652 DNA-3-methyladenine glycosylase [EC: 3.2.2.21] [KO: K03652] [EC: 3.2.2.21] | | | | hypothetical protein; K07462 single-stranded-DNA-specific exonuclease [EC:3.1.-.-] [KO: K07462] [EC:3.1.-.-] | | DNA polymerase sliding clamp A; K04802 proliferating cell nuclear antigen [KO: K04802] | | DNA polymerase sliding clamp B2; K04802 proliferating cell nuclear antigen [KO: K04802] | | DNA polymerase sliding clamp B1; K04802 proliferating cell nuclear antigen [KO: K04802] | | fen; flap endonuclease-1 [KO: K04799] [EC:3.-.-.-] | | |
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| Reference |
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| Authors |
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E. |
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| Title |
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease. |
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| Journal |
Acta Biochim Pol 54:413-34 (2007) |
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| Reference |
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| Authors |
Almeida KH, Sobol RW. |
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| Title |
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. |
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| Journal |
DNA Repair (Amst) 6:695-711 (2007) |
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| Reference |
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| Authors |
Ikeda S, Seki S. |
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| Title |
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 46:916-23 (2001) |
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| KO pathway |
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