KEGG   PATHWAY: api04146Help
Entry
api04146                    Pathway                                
Name
Peroxisome - Acyrthosiphon pisum (pea aphid)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
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Peroxisome
api04146

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Organism
Acyrthosiphon pisum (pea aphid) [GN:api]
Gene
Pex16; peroxisomal biogenesis factor 16 [KO:K13335]
peroxisomal biogenesis factor 3-like; K13336 peroxin-3 [KO:K13336]
peroxisomal biogenesis factor 19-like; K13337 peroxin-19 [KO:K13337]
ATP-binding cassette sub-family D member 3-like; K05677 ATP-binding cassette, subfamily D (ALD), member 3 [KO:K05677]
peroxisome biogenesis factor 1-like; K13338 peroxin-1 [KO:K13338]
peroxisome biogenesis protein 6-like; K13339 peroxin-6 [KO:K13339]
peroxisomal targeting signal 2 receptor-like; K13341 peroxin-7 [KO:K13341]
peroxisomal targeting signal 1 receptor-like; K13342 peroxin-5 [KO:K13342]
peroxisomal membrane protein PEX14-like; K13343 peroxin-14 [KO:K13343]
peroxisomal membrane protein PEX13-like; K13344 peroxin-13 [KO:K13344]
peroxisome assembly protein 12-like; K13345 peroxin-12 [KO:K13345]
peroxisome biogenesis factor 10-like; K13346 peroxin-10 [KO:K13346]
peroxisome biogenesis factor 2-like; K06664 peroxin-2 [KO:K06664]
peroxisomal membrane protein PMP22-like; K13347 peroxisomal membrane protein 2 [KO:K13347]
mpv17-like protein 2-like; K13348 protein Mpv17 [KO:K13348]
mpv17-like protein 2-like; K13348 protein Mpv17 [KO:K13348]
MPV17 mitochondrial membrane protein-like; K13349 Mpv17-like protein [KO:K13349]
peroxisomal membrane protein 11A-like; K13352 peroxin-11B [KO:K13352]
2-hydroxyacyl-CoA lyase 1-like; K12261 2-hydroxyacyl-CoA lyase 1 [EC:4.1.-.-] [KO:K12261] [EC:4.1.-.-]
alpha-methylacyl-CoA racemase-like; K01796 alpha-methylacyl-CoA racemase [EC:5.1.99.4] [KO:K01796] [EC:5.1.99.4]
phytanoyl-CoA dioxygenase; K00477 phytanoyl-CoA hydroxylase [EC:1.14.11.18] [KO:K00477] [EC:1.14.11.18]
probable peroxisomal acyl-coenzyme A oxidase 1-like; K00232 acyl-CoA oxidase [EC:1.3.3.6] [KO:K00232] [EC:1.3.3.6]
probable peroxisomal acyl-coenzyme A oxidase 1-like; K00232 acyl-CoA oxidase [EC:1.3.3.6] [KO:K00232] [EC:1.3.3.6]
peroxisomal acyl-coenzyme A oxidase 3-like; K00232 acyl-CoA oxidase [EC:1.3.3.6] [KO:K00232] [EC:1.3.3.6]
peroxisomal multifunctional enzyme type 2-like; K12405 3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase [EC:1.1.1.35 4.2.1.107] [KO:K12405] [EC:4.2.1.107 1.1.1.35]
non-specific lipid-transfer protein-like; K08764 sterol carrier protein 2 [EC:2.3.1.176] [KO:K08764] [EC:2.3.1.176]
delta(3; K12663 delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase [EC:5.3.3.-] [KO:K12663] [EC:5.3.3.-]
ATP-binding cassette sub-family D member 2-like; K05676 ATP-binding cassette, subfamily D (ALD), member 2 [KO:K05676]
long-chain-fatty-acid--CoA ligase 3-like; K01897 long-chain acyl-CoA synthetase [EC:6.2.1.3] [KO:K01897] [EC:6.2.1.3]
long-chain-fatty-acid--CoA ligase 1-like; K01897 long-chain acyl-CoA synthetase [EC:6.2.1.3] [KO:K01897] [EC:6.2.1.3]
peroxisomal 3; K13239 peroxisomal 3,2-trans-enoyl-CoA isomerase [EC:5.3.3.8] [KO:K13239] [EC:5.3.3.8]
nucleoside diphosphate-linked moiety X motif 19; K13355 nucleoside diphosphate-linked moiety X motif 19, mitochondrial [EC:3.6.1.-] [KO:K13355] [EC:3.6.1.-]
dihydroxyacetone phosphate acyltransferase-like; K00649 glyceronephosphate O-acyltransferase [EC:2.3.1.42] [KO:K00649] [EC:2.3.1.42]
alkyldihydroxyacetonephosphate synthase-like; K00803 alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26] [KO:K00803] [EC:2.5.1.26]
putative fatty acyl-CoA reductase CG5065-like; K13356 fatty acyl-CoA reductase [EC:1.2.1.-] [KO:K13356] [EC:1.2.1.-]
putative fatty acyl-CoA reductase CG5065-like; K13356 fatty acyl-CoA reductase [EC:1.2.1.-] [KO:K13356] [EC:1.2.1.-]
putative fatty acyl-CoA reductase CG5065-like; K13356 fatty acyl-CoA reductase [EC:1.2.1.-] [KO:K13356] [EC:1.2.1.-]
putative fatty acyl-CoA reductase CG5065-like; K13356 fatty acyl-CoA reductase [EC:1.2.1.-] [KO:K13356] [EC:1.2.1.-]
putative fatty acyl-CoA reductase CG5065-like; K13356 fatty acyl-CoA reductase [EC:1.2.1.-] [KO:K13356] [EC:1.2.1.-]
mevalonate kinase-like; K00869 mevalonate kinase [EC:2.7.1.36] [KO:K00869] [EC:2.7.1.36]
phosphomevalonate kinase-like; K13273 phosphomevalonate kinase [EC:2.7.4.2] [KO:K13273] [EC:2.7.4.2]
phosphomevalonate kinase-like; K13273 phosphomevalonate kinase [EC:2.7.4.2] [KO:K13273] [EC:2.7.4.2]
isocitrate dehydrogenase [NADP] cytoplasmic-like; K00031 isocitrate dehydrogenase [EC:1.1.1.42] [KO:K00031] [EC:1.1.1.42]
isocitrate dehydrogenase [NADP]; K00031 isocitrate dehydrogenase [EC:1.1.1.42] [KO:K00031] [EC:1.1.1.42]
hydroxymethylglutaryl-CoA lyase; K01640 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] [KO:K01640] [EC:4.1.3.4]
hydroxyacid oxidase 1-like; K11517 (S)-2-hydroxy-acid oxidase [EC:1.1.3.15] [KO:K11517] [EC:1.1.3.15]
catalase-like; K03781 catalase [EC:1.11.1.6] [KO:K03781] [EC:1.11.1.6]
peroxiredoxin-5; K11187 peroxiredoxin 5, atypical 2-Cys peroxiredoxin [EC:1.11.1.15] [KO:K11187] [EC:1.11.1.15]
superoxide dismutase [Cu-Zn]-like; K04565 superoxide dismutase, Cu-Zn family [EC:1.15.1.1] [KO:K04565] [EC:1.15.1.1]
superoxide dismutase [Cu-Zn]-like; K04565 superoxide dismutase, Cu-Zn family [EC:1.15.1.1] [KO:K04565] [EC:1.15.1.1]
superoxide dismutase [Mn]; K04564 superoxide dismutase, Fe-Mn family [EC:1.15.1.1] [KO:K04564] [EC:1.15.1.1]
xanthine dehydrogenase-like; K00106 xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2] [KO:K00106] [EC:1.17.3.2 1.17.1.4]
dehydrogenase/reductase SDR family member 4-like; K11147 dehydrogenase/reductase SDR family member 4 [EC:1.1.-.-] [KO:K11147] [EC:1.1.-.-]
Reference
  Authors
Schluter A, Real-Chicharro A, Gabaldon T, Sanchez-Jimenez F, Pujol A
  Title
PeroxisomeDB 2.0: an integrative view of the global peroxisomal metabolome.
  Journal
Nucleic Acids Res 38:D800-5 (2010)
Reference
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
Reference
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
Reference
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
Reference
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of  antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
Reference
  Authors
Kleinman R, Goulet OJ, Mieli-Vergani G, Sanderson I, Sherman P, Shneider B.
  Title
Walker's Pediatric Gastrointestinal Disease (5th edition)
  Journal
B.C.Decker (2008)
KO pathway
 
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