KEGG   PATHWAY: apj03440Help
Entry
apj03440                    Pathway                                

Name
Homologous recombination - Actinobacillus pleuropneumoniae JL03 (serotype 3)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
apj03440  Homologous recombination
apj03440

Ortholog table
Module
apj_M00260  DNA polymerase III complex, bacteria [PATH:apj03440]
Other DBs
BSID: 63131
GO: 0000724
Organism
Actinobacillus pleuropneumoniae JL03 (serotype 3) [GN:apj]
Gene
APJL_0486  recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
APJL_0787  ssb; single stranded DNA binding protein [KO:K03111]
APJL_0003  recF; DNA replication and repair protein [KO:K03629]
APJL_0538  recO; DNA repair protein [KO:K03584]
APJL_0074  recR; recombination DNA repair protein [KO:K06187]
APJL_1163  recA; RecA protein [KO:K03553]
APJL_0500  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
APJL_0295  ruvB; Holliday junction DNA helicase [KO:K03551] [EC:3.6.4.12]
APJL_1173  ruvC; crossover junction endodeoxyribonuclease [KO:K01159] [EC:3.1.22.4]
APJL_1863  recG; ATP-dependent DNA helicase [KO:K03655] [EC:3.6.4.12]
APJL_0388  recB; exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
APJL_1927  recC; exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
APJL_0261  recD; exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
APJL_1120  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
APJL_0002  dnaN; DNA polymerase III beta chain [KO:K02338] [EC:2.7.7.7]
APJL_0273  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
APJL_0886  holA; DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
APJL_1852  holB; DNA polymerase III delta' subunit [KO:K02341] [EC:2.7.7.7]
APJL_1294  dnaQ; DNA polymerase III epsilon chain [KO:K02342] [EC:2.7.7.7]
APJL_1531  holC; DNA polymerase III chi subunit [KO:K02339] [EC:2.7.7.7]
APJL_2056  holD; DNA polymerase III psi subunit protein [KO:K02344] [EC:2.7.7.7]
APJL_1050  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
APJL_1191  priB; primosomal replication protein [KO:K02686]
APJL_0640  hypothetical protein [KO:K04067]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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