KEGG   PATHWAY: apz00020Help
Entry
apz00020                    Pathway                                

Name
Citrate cycle (TCA cycle) - Acetobacter pasteurianus IFO 3283-32
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
apz00020  Citrate cycle (TCA cycle)
apz00020

Ortholog table
Module
apz_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:apz00020]
apz_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:apz00020]
apz_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:apz00020]
apz_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:apz00020]
Other DBs
BSID: 590730
GO: 0006099
Organism
Acetobacter pasteurianus IFO 3283-32 [GN:apz]
Gene
APA32_10670  citrate synthase [KO:K01647] [EC:2.3.3.1]
APA32_25120  aconitate hydratase [KO:K01681] [EC:4.2.1.3]
APA32_06250  isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
APA32_10420  isocitrate dehydrogenase [KO:K00030] [EC:1.1.1.41]
APA32_07660  2-oxoglutarate dehydrogenase E1 component [KO:K00164] [EC:1.2.4.2]
APA32_07670  2-oxoglutarate dehydrogenase E2 component [KO:K00658] [EC:2.3.1.61]
APA32_07680  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
APA32_12150  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
APA32_10710  acetyl-CoA hydrolase [KO:K18118] [EC:2.8.3.18]
APA32_00330  succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:1.3.5.4 1.3.5.1]
APA32_00340  succinate dehydrogenase Fe-S protein subunit [KO:K00240] [EC:1.3.5.4 1.3.5.1]
APA32_00310  succinate dehydrogenase cytochrome b subunit [KO:K00241]
APA32_00320  succinate dehydrogenase membrane anchor subunit [KO:K00242]
APA32_24940  fumarate hydratase [KO:K01676] [EC:4.2.1.2]
APA32_14580  fumarate hydratase [KO:K01679] [EC:4.2.1.2]
APA32_11550  malate:quinone oxidoreductase [KO:K00116] [EC:1.1.5.4]
APA32_12180  pyruvate dehydrogenase E1 component alpha subunit [KO:K00161] [EC:1.2.4.1]
APA32_12170  pyruvate dehydrogenase E1 component beta subunit [KO:K00162] [EC:1.2.4.1]
APA32_12160  dihydrolipoamide acetyltransferase component [KO:K00627] [EC:2.3.1.12]
APA32_05960  esterase/lipase [KO:K00627] [EC:2.3.1.12]
APA32_14730  pyruvate ferredoxin/flavodoxin oxidoreductase [KO:K03737] [EC:1.2.7.- 1.2.7.1]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 2)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 3)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
ko00020   

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