KEGG   PATHWAY: asd03430
Entry
asd03430                    Pathway                                
Name
Mismatch repair - Hoyosella subflava
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
asd03430  Mismatch repair
asd03430

Other DBs
GO: 0006298
Organism
Hoyosella subflava [GN:asd]
Gene
AS9A_P20119  ATP-dependent DNA helicase PcrA [KO:K03657] [EC:5.6.2.4]
AS9A_3749  putative ATP-dependent DNA helicase [KO:K03657] [EC:5.6.2.4]
AS9A_3585  uvrD1; ATP-dependent DNA helicase UvrD1 [KO:K03657] [EC:5.6.2.4]
AS9A_3744  Helicase [KO:K03657] [EC:5.6.2.4]
AS9A_3400  xseA; Exodeoxyribonuclease 7 large subunit [KO:K03601] [EC:3.1.11.6]
AS9A_3401  Exodeoxyribonuclease 7 small subunit [KO:K03602] [EC:3.1.11.6]
AS9A_1059  Single-stranded DNA-binding protein [KO:K03111]
AS9A_4530  Single-stranded DNA-binding protein [KO:K03111]
AS9A_1376  dnaE; Putative DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
AS9A_0002  dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
AS9A_4201  Transcriptional regulator, MerR family [KO:K02338] [EC:2.7.7.7]
AS9A_0217  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
AS9A_1145  DNA-directed DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
AS9A_0296  DNA-directed DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
AS9A_1285  dnaQ; Putative DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
AS9A_3213  ligA; DNA ligase [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair]
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   

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