KEGG PATHWAY: ath04120

PATHWAY: ath04120

Entry

ath04120 Pathway

Name

Ubiquitin mediated proteolysis - Arabidopsis thaliana (thale cress)

Description

Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.

Class

Genetic Information Processing; Folding, sorting and degradation

Pathway map

ath04120

Ubiquitin mediated proteolysis

Module

ath_M00379	SCF-MET30 complex [PATH:ath04120]
ath_M00380	SCF-BTRC complex [PATH:ath04120]
ath_M00381	SCF-SKP2 complex [PATH:ath04120]
ath_M00382	SCF-FBS complex [PATH:ath04120]
ath_M00383	ECV complex [PATH:ath04120]
ath_M00384	Cul3-SPOP complex [PATH:ath04120]
ath_M00385	Cul4-DDB1-DDB2 complex [PATH:ath04120]
ath_M00386	Cul4-DDB1-CSA complex [PATH:ath04120]
ath_M00387	SCF-FBW7 complex [PATH:ath04120]
ath_M00388	ECS complex [PATH:ath04120]
ath_M00389	APC/C complex [PATH:ath04120]
ath_M00407	SCF-CDC4 complex [PATH:ath04120]
ath_M00411	SCF-GRR1 complex [PATH:ath04120]

Other DBs

BSID:

4111

GO:

0016567

Organism

Arabidopsis thaliana (thale cress) [GN:ath]

Gene

AT2G30110	UBA1; ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.3.2.19]
AT5G06460	UBA_2; ubiquitin-activating enzyme E1 2 [KO:K03178] [EC:6.3.2.19]
AT5G50580	SAE1B; SUMO-activating enzyme subunit 1B [KO:K10684] [EC:6.3.2.19]
AT4G24940	SAE1A; SUMO-activating enzyme subunit 1A [KO:K10684] [EC:6.3.2.19]
AT5G50680	SAE1B; SUMO-activating enzyme subunit 1B [KO:K10684] [EC:6.3.2.19]
AT2G21470	SAE2; SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.3.2.19]
AT5G19180	ECR1; ubiquitin-activating enzyme E1 C [KO:K10686] [EC:6.3.2.19]
AT1G14400	UBC1; ubiquitin-conjugating enzyme E2 1 [KO:K10573] [EC:6.3.2.19]
AT2G02760	UBC2; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:6.3.2.19]
AT5G62540	UBC3; ubiquitin-conjugating enzyme E2 3 [KO:K10573] [EC:6.3.2.19]
AT3G20060	UBC19; ubiquitin-conjugating enzyme E2 19 [KO:K06688] [EC:6.3.2.19]
AT1G50490	UBC20; ubiquitin-conjugating enzyme E2 20 [KO:K06688] [EC:6.3.2.19]
AT5G41340	UBC4; ubiquitin-conjugating enzyme E2 4 [KO:K06689] [EC:6.3.2.19]
AT3G08690	UBC11; ubiquitin-conjugating enzyme E2 11 [KO:K06689] [EC:6.3.2.19]
AT1G36340	UBC31; ubiquitin-conjugating enzyme E2 D/E [KO:K06689] [EC:6.3.2.19]
AT2G32790	ubiquitin-conjugating enzyme E2 D/E; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:6.3.2.19] [KO:K06689] [EC:6.3.2.19]
AT2G16740	UBC29; ubiquitin-conjugating enzyme E2 29 [KO:K06689] [EC:6.3.2.19]
AT3G08700	UBC12; putative ubiquitin-conjugating enzyme E2 12 [KO:K06689] [EC:6.3.2.19]
AT1G64230	UBC28; ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:6.3.2.19]
AT5G56150	UBC30; ubiquitin-conjugating enzyme E2 30 [KO:K06689] [EC:6.3.2.19]
AT5G53300	UBC10; ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:6.3.2.19]
AT5G41700	UBC8; ubiquitin-conjugating enzyme E2 8 [KO:K06689] [EC:6.3.2.19]
AT3G46460	UBC13; ubiquitin-conjugating enzyme E2 13 [KO:K10575] [EC:6.3.2.19]
AT3G55380	UBC14; ubiquitin-conjugating enzyme E2 14 [KO:K10575] [EC:6.3.2.19]
AT5G59300	UBC7; ubiquitin carrier protein 7 [KO:K10575] [EC:6.3.2.19]
AT1G63800	UBC5; ubiquitin-conjugating enzyme E2 5 [KO:K10576] [EC:6.3.2.19]
AT2G46030	UBC6; ubiquitin-conjugating enzyme E2 6 [KO:K10576] [EC:6.3.2.19]
AT3G57870	SCE1; SUMO-conjugating enzyme SCE1 [KO:K10577] [EC:6.3.2.19]
AT3G17000	UBC32; ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:6.3.2.19]
AT1G17280	UBC34; ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:6.3.2.19]
AT5G50430	UBC33; putative ubiquitin-conjugating enzyme E2 33 [KO:K04554] [EC:6.3.2.19]
AT2G18600	ubiquitin-conjugating enzyme E2 M; K10579 ubiquitin-conjugating enzyme E2 M [EC:6.3.2.19] [KO:K10579] [EC:6.3.2.19]
AT4G36800	RCE1; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:6.3.2.19]
AT1G16890	UBC36; ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:6.3.2.19]
AT1G78870	UBC35; ubiquitin-conjugating enzyme E2 35 [KO:K10580] [EC:6.3.2.19]
AT2G16920	UBC23; putative ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:6.3.2.19]
AT1G53025	Ubiquitin-conjugating enzyme family protein; K10581 ubiquitin-conjugating enzyme E2 O [EC:6.3.2.19] [KO:K10581] [EC:6.3.2.19]
AT1G53023	Ubiquitin-conjugating enzyme family protein; K10581 ubiquitin-conjugating enzyme E2 O [EC:6.3.2.19] [KO:K10581] [EC:6.3.2.19]
AT3G15355	UBC25; putative ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:6.3.2.19]
AT2G33770	PHO2; putative ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:6.3.2.19]
AT5G05080	UBC22; ubiquitin-conjugating enzyme E2 22 [KO:K10583] [EC:6.3.2.19]
AT1G75440	UBC16; putative ubiquitin-conjugating enzyme E2 16 [KO:K10688] [EC:6.3.2.19]
AT1G45050	ATUBC2-1; ubiquitin-conjugating enzyme 15 [KO:K10688] [EC:6.3.2.19]
AT5G42990	UBC18; putative ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:6.3.2.19]
AT4G36410	UBC17; putative ubiquitin-conjugating enzyme E2 17 [KO:K10688] [EC:6.3.2.19]
AT5G50870	UBC27; ubiquitin-conjugating enzyme E2 27 [KO:K04649] [EC:6.3.2.19]
AT3G53090	UPL7; E3 ubiquitin-protein ligase UPL7 [KO:K10588] [EC:6.3.2.19]
AT3G17205	UPL6; E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:6.3.2.19]
AT4G38600	KAK; E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:6.3.2.19]
AT5G02880	UPL4; E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:6.3.2.19]
AT4G12570	UPL5; E3 ubiquitin-protein ligase UPL5 [KO:K10591] [EC:6.3.2.19]
AT1G70320	UPL2; ubiquitin-protein ligase 2 [KO:K10592] [EC:6.3.2.19]
AT1G55860	UPL1; ubiquitin-protein ligase 1 [KO:K10592] [EC:6.3.2.19]
AT5G15400	putative ubiquitin conjugation factor E4; K10597 ubiquitin conjugation factor E4 B [EC:6.3.2.19] [KO:K10597] [EC:6.3.2.19]
AT3G07370	CHIP; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:6.3.2.19]
AT5G67530	PUB49; Peptidyl-prolyl cis-trans isomerase-like 2 [KO:K10598] [EC:5.2.1.8]
AT1G04510	MAC3A; Pre-mRNA-processing factor 19 [KO:K10599] [EC:6.3.2.19]
AT2G33340	MAC3B; Pre-mRNA-processing factor 19-2 [KO:K10599] [EC:6.3.2.19]
AT3G58040	SINAT2; E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:6.3.2.19]
AT2G41980	ubiquitin-protein ligase SIAH1; K04506 E3 ubiquitin-protein ligase SIAH1 [EC:6.3.2.19] [KO:K04506] [EC:6.3.2.19]
AT4G27880	E3 ubiquitin-protein ligase SINAT4; K04506 E3 ubiquitin-protein ligase SIAH1 [EC:6.3.2.19] [KO:K04506] [EC:6.3.2.19]
AT3G61790	E3 ubiquitin-protein ligase SINAT3; K04506 E3 ubiquitin-protein ligase SIAH1 [EC:6.3.2.19] [KO:K04506] [EC:6.3.2.19]
AT2G32950	COP1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:6.3.2.19]
AT5G52250	transducin/WD40 domain-containing protein; K10143 E3 ubiquitin-protein ligase RFWD2 [EC:6.3.2.19] [KO:K10143] [EC:6.3.2.19]
AT5G23730	transducin/WD40 domain-containing protein; K10143 E3 ubiquitin-protein ligase RFWD2 [EC:6.3.2.19] [KO:K10143] [EC:6.3.2.19]
AT3G62970	ring finger and CHY zinc finger domain-containing protein 1; K10144 RING finger and CHY zinc finger domain-containing protein 1 [EC:6.3.2.19] [KO:K10144] [EC:6.3.2.19]
AT5G18650	ring finger and CHY zinc finger domain-containing protein 1; K10144 RING finger and CHY zinc finger domain-containing protein 1 [EC:6.3.2.19] [KO:K10144] [EC:6.3.2.19]
AT5G22920	ring finger and CHY zinc finger domain-containing protein 1; K10144 RING finger and CHY zinc finger domain-containing protein 1 [EC:6.3.2.19] [KO:K10144] [EC:6.3.2.19]
AT5G25560	CHY and CTCHY and RING-type zinc finger protein; K10144 RING finger and CHY zinc finger domain-containing protein 1 [EC:6.3.2.19] [KO:K10144] [EC:6.3.2.19]
AT5G41580	RING/U-box domain-containing protein; K04706 E3 SUMO-protein ligase PIAS1 [EC:6.3.2.-] [KO:K04706] [EC:6.3.2.-]
AT1G08910	EMB3001; zinc ion binding protein [KO:K04706] [EC:6.3.2.-]
AT3G16090	ubiquitin-protein ligase synoviolin; K10601 E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19] [KO:K10601] [EC:6.3.2.19]
AT1G65040	ubiquitin-protein ligase synoviolin; K10601 E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19] [KO:K10601] [EC:6.3.2.19]
AT5G65740	zinc ion binding protein; K10606 E3 ubiquitin-protein ligase FANCL [EC:6.3.2.19] [KO:K10606] [EC:6.3.2.19]
AT3G42830	RING-box protein 1; K03868 RING-box protein 1 [KO:K03868]
AT5G20570	RBX1; RING-box protein 1 [KO:K03868]
AT4G02570	CUL1; cullin 1 [KO:K03347]
AT1G02980	CUL2; cullin 2 [KO:K03347]
AT1G59790	putative cullin-like protein 2; K03347 cullin 1 [KO:K03347]
AT1G59800	cullin-like protein 3; K03347 cullin 1 [KO:K03347]
AT1G43140	cullin-like protein; K03347 cullin 1 [KO:K03347]
AT1G75950	SKP1; S-phase kinase-associated protein 1 [KO:K03094]
AT5G42190	ASK2; S-phase kinase-associated protein 1 [KO:K03094]
AT1G20140	SK4; S-phase kinase-associated protein 1 [KO:K03094]
AT2G25700	SK3; S-phase kinase-associated protein 1 [KO:K03094]
AT2G03170	SK14; S-phase kinase-associated protein 1 [KO:K03094]
AT3G21830	SK8; S-phase kinase-associated protein 1 [KO:K03094]
AT3G21850	SK9; S-phase kinase-associated protein 1 [KO:K03094]
AT3G21860	SK10; S-phase kinase-associated protein 1 [KO:K03094]
AT3G60010	SK13; S-phase kinase-associated protein 1 [KO:K03094]
AT4G34210	SK11; S-phase kinase-associated protein 1 [KO:K03094]
AT4G34470	SK12; S-phase kinase-associated protein 1 [KO:K03094]
AT1G10230	SK18; S-phase kinase-associated protein 1 [KO:K03094]
AT2G03160	SK19; S-phase kinase-associated protein 1 [KO:K03094]
AT2G03190	SK16; S-phase kinase-associated protein 1 [KO:K03094]
AT2G20160	MEO; S-phase kinase-associated protein 1 [KO:K03094]
AT3G25650	SK15; S-phase kinase-associated protein 1 [KO:K03094]
AT3G60020	SK5; S-phase kinase-associated protein 1 [KO:K03094]
AT3G21840	SK7; S-phase kinase-associated protein 1 [KO:K03094]
AT3G53060	SK6; S-phase kinase-associated protein 1 [KO:K03094]
AT1G77000	SKP2B; F-box/LRR-repeat protein 5 [KO:K03875]
AT5G59140	transcription elongation factor B; K03872 transcription elongation factor B, polypeptide 1 [KO:K03872]
AT1G26830	CUL3; cullin 3 [KO:K03869]
AT1G69670	CUL3B; cullin 3B [KO:K03869]
AT5G46210	CUL4; cullin4 [KO:K10609]
AT3G46910	putative cullin-like protein 4; K10609 cullin 4 [KO:K10609]
AT4G12100	cullin-like protein 5; K10609 cullin 4 [KO:K10609]
AT4G05420	DDB1A; DNA damage-binding protein 1a [KO:K10610]
AT4G21100	DDB1B; DNA damage-binding protein 1b [KO:K10610]
AT5G58760	DDB2; DNA damage-binding protein 2 [KO:K10140]
AT1G19750	DNA excision repair protein ERCC-8; K10570 DNA excision repair protein ERCC-8 [KO:K10570]
AT1G27840	ATCSA-1; transducin/WD-40 repeat-containing protein [KO:K10570]
AT4G10180	DET1; Light-mediated development protein DET1 [KO:K10571]
AT3G05870	APC11; anaphase-promoting complex subunit 11 [KO:K03358]
AT2G04660	APC2; anaphase-promoting complex subunit 2 [KO:K03349]
AT4G33270	CDC20.1; cell division cycle 20, cofactor of APC complex [KO:K03363]
AT5G27945	cell division cycle 20; K03363 cell division cycle 20, cofactor of APC complex [KO:K03363]
AT5G26900	cell division cycle 20; K03363 cell division cycle 20, cofactor of APC complex [KO:K03363]
AT5G27080	cell division cycle 20; K03363 cell division cycle 20, cofactor of APC complex [KO:K03363]
AT5G27570	cell division cycle 20; K03363 cell division cycle 20, cofactor of APC complex [KO:K03363]
AT4G33260	CDC20.2; cell division cycle 20, cofactor of APC complex [KO:K03363]
AT4G22910	FZR2; protein FIZZY-related 2 [KO:K03364]
AT4G11920	CCS52A2; protein FIZZY-related 1 [KO:K03364]
AT5G13840	FZR3; protein FIZZY-related 3 [KO:K03364]
AT5G05560	EMB2771; anaphase-promoting complex subunit 1 [KO:K03348]
AT2G20000	HBT; cell division cycle protein 27-B [KO:K03350]
AT3G16320	CDC27a; cell division cycle protein 27-A [KO:K03350]
AT4G21530	anaphase-promoting complex subunit 4; K03351 anaphase-promoting complex subunit 4 [KO:K03351]
AT1G06590	anaphase-promoting complex subunit 5; K03352 anaphase-promoting complex subunit 5 [KO:K03352]
AT1G78770	APC6; anaphase-promoting complex subunit 6 [KO:K03353]
AT2G39090	anaphase-promoting complex subunit 7; K03354 anaphase-promoting complex subunit 7 [KO:K03354]
AT4G10000	thioredoxin family protein; K03354 anaphase-promoting complex subunit 7 [KO:K03354]
AT3G48150	APC8; anaphase-promoting complex subunit 8 [KO:K03355]
AT2G18290	APC10; anaphase-promoting complex subunit 10 [KO:K03357]
AT1G73177	BNS; prtoein BONSAI [KO:K12456]

Reference

PMID:16922370 (Japanese)

Authors

Kamura T.

Title

[Cullin-based E3 family] Japanese

Journal

Tanpakushitsu Kakusan Koso 51:1167-72 (2006)

Reference

PMID:16922408 (Japanese)

Authors

Matsuda N.

Title

[Overview: hereditary disorders caused by dysfunction of ubiquitylation]

Journal

Tanpakushitsu Kakusan Koso 51:1402-7 (2006)

Reference

PMID:16922367 (Japanese)

Authors

Tokunaga F.

Title

[E2 ubiquitin-conjugating enzymes: structures and functions]

Journal

Tanpakushitsu Kakusan Koso 51:1150-6 (2006)

Reference

PMID:16816840

Authors

Nalepa G, Rolfe M, Harper JW.

Title

Drug discovery in the ubiquitin-proteasome system.

Journal

Nat Rev Drug Discov 5:596-613 (2006)

Reference

PMID:16405856

Authors

Hsu YJ, Goodman SR.

Title

Spectrin and ubiquitination: a review.

Journal

Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)

Reference

PMID:12944364

Authors

Hatakeyama S, Nakayama KI.

Title

Ubiquitylation as a quality control system for intracellular proteins.

Journal

J Biochem 134:1-8 (2003)

Reference

PMID:17588513

Authors

Lee J, Zhou P.

Title

DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.

Journal

Mol Cell 26:775-80 (2007)

KO pathway

ko04120

All links

Pathway (6)   
   KEGG MODULE (5)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (135)   
   KEGG GENES (135)   
All databases (142)   

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