KEGG   PATHWAY: avn03440
Entry
avn03440                    Pathway                                
Name
Homologous recombination - Azotobacter vinelandii DJ
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
avn03440  Homologous recombination
avn03440

Other DBs
GO: 0000724
Organism
Azotobacter vinelandii DJ [GN:avn]
Gene
Avin_39440  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Avin_06540  Single-strand DNA binding protein [KO:K03111]
Avin_00030  recF; DNA replication and repair protein, RecF [KO:K03629]
Avin_13820  recO; DNA repair protein RecO [KO:K03584]
Avin_19850  recR; RecR protein [KO:K06187]
Avin_38560  recA; bacterial DNA recombination protein [KO:K03553]
Avin_00630  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Avin_36700  ruvA; holliday junction DNA helicase RuvA [KO:K03550]
Avin_36690  ruvB; holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Avin_36710  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Avin_48450  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Avin_51710  recB; exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
Avin_51720  recC; exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
Avin_51700  recD; exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
Avin_38840  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
Avin_00020  DNA polymerase III, beta chain 1, 2, and 3 protein [KO:K02338] [EC:2.7.7.7]
Avin_19830  dnaX; DNA-directed DNA polymerase III, gamma and tau subunits [KO:K02343] [EC:2.7.7.7]
Avin_08980  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Avin_14980  holB; DNA polymerase III delta prime subunit [KO:K02341] [EC:2.7.7.7]
Avin_05890  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Avin_29590  dnaQ; DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Avin_11640  DNA polymerase III chi subunit, HolC [KO:K02339] [EC:2.7.7.7]
Avin_45350  priA; primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG GENES (23)   
All databases (24)   

Download RDF
DBGET integrated database retrieval system