The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].

Metabolism; Carbohydrate metabolism

Azoarcus sp. BH72 [GN:azo]

(map 3)

Nishizuka Y (ed).

[Metabolic Maps] (In Japanese)

Tokyo Kagaku Dojin (1980)

(map 4)

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

[Cellular Functions and Metabolic Maps] (In Japanese)

Tokyo Kagaku Dojin (1997)

Michal G.

Biochemical Pathways

Wiley (1999)

PMID:12700258

Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.

Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.

J Bacteriol 185:2793-801 (2003)

PMID:16788179

Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y

The ribulose monophosphate pathway substitutes for the missing pentose phosphate  pathway in the archaeon Thermococcus kodakaraensis.

J Bacteriol 188:4698-704 (2006)

PMID:16428816

Kato N, Yurimoto H, Thauer RK

The physiological role of the ribulose monophosphate pathway in bacteria and archaea.

Biosci Biotechnol Biochem 70:10-21 (2006)

PMID:23279921

Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B

Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.

FEBS J 280:1126-38 (2013)

PMID:16458304

Reher M, Schonheit P

Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.

FEBS Lett 580:1198-204 (2006)

PMID:20023024

Reher M, Fuhrer T, Bott M, Schonheit P

The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.

J Bacteriol 192:964-74 (2010)