KEGG   PATHWAY: bbb00290
Entry
bbb00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Bifidobacterium animalis subsp. lactis BB-12
Class
Metabolism; Amino acid metabolism
Pathway map
bbb00290  Valine, leucine and isoleucine biosynthesis
bbb00290

Module
bbb_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:bbb00290]
bbb_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:bbb00290]
bbb_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:bbb00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Bifidobacterium animalis subsp. lactis BB-12 [GN:bbb]
Gene
BIF_01598  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
BIF_02390  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BIF_01510  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BIF_02900  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
BIF_00863  acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
BIF_01769  ilvN; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
BIF_01396  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
BIF_00467  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
BIF_01826  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
BIF_02076  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K14260] [EC:2.6.1.66 2.6.1.2]
BIF_01494  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
bbb00260  Glycine, serine and threonine metabolism
bbb00280  Valine, leucine and isoleucine degradation
bbb00620  Pyruvate metabolism
KO pathway
ko00290   

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