KEGG   PATHWAY: bbo03008Help
Entry
bbo03008                    Pathway                                
Name
Ribosome biogenesis in eukaryotes - Babesia bovis
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is  assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Ribosome biogenesis in eukaryotes
bbo03008

All organismsOrtholog table
Module
H/ACA ribonucleoprotein complex [PATH:bbo03008]
Organism
Babesia bovis [GN:bbo]
Gene
18.m06515; protein kinase CK2 regulatory subunit CK2B1 [KO:K03115]
23.m05738; casein kinase II beta 4 subunit [KO:K03115]
17.m07683; casein kinase II, alpha chain (CK II) [KO:K03097] [EC:2.7.11.1]
23.m05808; hypothetical protein [KO:K14544]
19.m02216; hypothetical protein [KO:K14546]
23.m06499; WD domain, G-beta repeat containing protein [KO:K14552]
17.m07984; hypothetical protein [KO:K14553]
23.m06340; WD domain, G-beta repeat containing protein [KO:K14554]
17.m07962; WD domain, G-beta repeat containing protein [KO:K14556]
17.m10521; hypothetical protein [KO:K14557]
18.m06073; periodic tryptophan protein 2-like protein [KO:K14558]
21.m02752; U3 small nucleolar ribonucleoprotein protein [KO:K14559]
21.m02848; U3 small nucleolar ribonucleoprotein protein IMP3-like protein [KO:K14560]
16.m00780; Brix domain containing protein [KO:K14561]
17.m07778; fibrillarin [KO:K14563] [EC:2.1.1.-]
23.m05998; nucleolar protein Nop56 [KO:K14564]
18.m06502; nucleolar protein NOP5 [KO:K14565]
17.m07845; ribosomal protein L7A [KO:K12845]
18.m06459; rRNA pseudouridine synthase family protein [KO:K11131] [EC:5.4.99.-]
18.m06174; gar1 protein RNA binding region containing protein [KO:K11128]
23.m05786; ribosome biogeneisis subunit NOP10 [KO:K11130]
18.m06530; hypothetical protein [KO:K14566]
19.m02290; suppressor Mra1 family domain containing protein [KO:K14568] [EC:2.1.1.260]
17.m07199; hypothetical protein [KO:K14568] [EC:2.1.1.260]
17.m07327; hypothetical protein [KO:K14569]
17.m07395; ATPase domain containing protein [KO:K14521] [EC:2.3.1.-]
23.m06448; RNA 3'-terminal phosphate cyclase [KO:K11108]
17.m07068; ribonucleases domain containing protein [KO:K01164] [EC:3.1.26.5]
23.m05744; hypothetical protein [KO:K03538] [EC:3.1.26.5]
16.m00713; hypothetical protein [KO:K03539] [EC:3.1.26.5]
17.m07602; exonuclease family protein [KO:K14570] [EC:3.1.-.-]
18.m06591; 5'-3' exoribonuclease (XRN2) [KO:K12618] [EC:3.1.13.-]
18.m06180; XRN 5'-3' exonuclease protein [KO:K12619] [EC:3.1.13.-]
17.m07392; nucleolar GTP-binding protein 1 [KO:K06943]
19.m02341; nucleolar GTP-binding protein 2 [KO:K14537]
23.m06332; ATPase AAA type domain containing protein [KO:K14571]
17.m07217; ATPase associated with various cellular activities (AAA) family protein [KO:K14572]
21.m02926; RNA binding protein [KO:K14573]
23.m06253; hypothetical protein [KO:K11883]
23.m06098; GTP-binding nuclear protein Ran [KO:K07936]
18.m06600; exportin 1 [KO:K14290]
23.m05734; nonsense-mediated mRNA decay protein [KO:K07562]
17.m07522; translation initiation factor eIF-6 family protein [KO:K03264]
23.m05967; hypothetical protein [KO:K14574]
23.m06487; GTPase subfamily protein [KO:K14539] [EC:3.6.1.-]
18.m06623; hypothetical protein [KO:K14535] [EC:2.7.4.3]
23.m06086; serine/threonine protein kinase [KO:K07178] [EC:2.7.11.1]
17.m07814; RIO1 family protein [KO:K07179] [EC:2.7.11.1]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
KO pathway
 
DBGET integrated database retrieval system