KEGG   PATHWAY: bcb03440
Entry
bcb03440                    Pathway                                
Name
Homologous recombination - Bacillus cereus B4264
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
bcb03440  Homologous recombination
bcb03440

Other DBs
GO: 0000724
Organism
Bacillus cereus B4264 [GN:bcb]
Gene
BCB4264_A4528  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
BCB4264_A2176  ssb2; single-stranded DNA-binding protein [KO:K03111]
BCB4264_A5600  ssb1; single-stranded DNA-binding protein [KO:K03111]
BCB4264_A3616  single-strand binding family protein [KO:K03111]
BCB4264_A0004  recF; DNA replication and repair protein RecF [KO:K03629]
BCB4264_A4415  recO; recombination protein O [KO:K03584]
BCB4264_A0026  recR; recombination protein RecR [KO:K06187]
BCB4264_A3878  recA; protein RecA [KO:K03553]
BCB4264_A4697  polA; DNA-directed DNA polymerase [KO:K02335] [EC:2.7.7.7]
BCB4264_A4540  ruvA; Holliday junction DNA helicase RuvA [KO:K03550]
BCB4264_A4539  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
BCB4264_A3954  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
BCB4264_A4514  putative helicase [KO:K03581] [EC:3.1.11.5]
BCB4264_A4714  dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
BCB4264_A3916  polC; DNA polymerase III, alpha subunit, Gram-positive type [KO:K03763] [EC:2.7.7.7]
BCB4264_A0002  dnaN1; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
BCB4264_A2706  dnaN2; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
BCB4264_A0024  dnaX; DNA polymerase III, gamma and tau subunits [KO:K02343] [EC:2.7.7.7]
BCB4264_A4442  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
BCB4264_A0036  holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
BCB4264_A3719  putative DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
BCB4264_A3967  priA; primosomal protein N` [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG GENES (22)   
All databases (23)   

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