KEGG   PATHWAY: bch00260Help
Entry
bch00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia cenocepacia HI2424
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Glycine, serine and threonine metabolism
bch00260

All organismsOrtholog table
Module
Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bch00260]
Serine biosynthesis, glycerate-3P => serine [PATH:bch00260]
Ectoine biosynthesis, aspartate => ectoine [PATH:bch00260]
Betaine biosynthesis, choline => betaine [PATH:bch00260]
Other DBs
Organism
Burkholderia cenocepacia HI2424 [GN:bch]
Gene
aspartate kinase; K00928 aspartate kinase [EC:2.7.2.4] [KO:K00928] [EC:2.7.2.4]
aspartate-semialdehyde dehydrogenase; K00133 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] [KO:K00133] [EC:1.2.1.11]
homoserine dehydrogenase; K00003 homoserine dehydrogenase [EC:1.1.1.3] [KO:K00003] [EC:1.1.1.3]
homoserine kinase; K02204 homoserine kinase type II [EC:2.7.1.39] [KO:K02204] [EC:2.7.1.39]
threonine synthase; K01733 threonine synthase [EC:4.2.3.1] [KO:K01733] [EC:4.2.3.1]
threonine aldolase; K01620 threonine aldolase [EC:4.1.2.5] [KO:K01620] [EC:4.1.2.5]
glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
serine hydroxymethyltransferase; K00600 glycine hydroxymethyltransferase [EC:2.1.2.1] [KO:K00600] [EC:2.1.2.1]
phosphoserine phosphatase SerB; K01079 phosphoserine phosphatase [EC:3.1.3.3] [KO:K01079] [EC:3.1.3.3]
phosphoserine aminotransferase; K00831 phosphoserine aminotransferase [EC:2.6.1.52] [KO:K00831] [EC:2.6.1.52]
D-isomer specific 2-hydroxyacid dehydrogenase; K00058 D-3-phosphoglycerate dehydrogenase [EC:1.1.1.95] [KO:K00058] [EC:1.1.1.95]
D-isomer specific 2-hydroxyacid dehydrogenase; K00058 D-3-phosphoglycerate dehydrogenase [EC:1.1.1.95] [KO:K00058] [EC:1.1.1.95]
D-isomer specific 2-hydroxyacid dehydrogenase; K00058 D-3-phosphoglycerate dehydrogenase [EC:1.1.1.95] [KO:K00058] [EC:1.1.1.95]
glycerate kinase; K00865 glycerate kinase [EC:2.7.1.31] [KO:K00865] [EC:2.7.1.31]
gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.1]
phosphoglycerate mutase; K15634 probable phosphoglycerate mutase [EC:5.4.2.1] [KO:K15634] [EC:5.4.2.1]
D-isomer specific 2-hydroxyacid dehydrogenase; K00018 glycerate dehydrogenase [EC:1.1.1.29] [KO:K00018] [EC:1.1.1.29]
D-isomer specific 2-hydroxyacid dehydrogenase; K12972 gyoxylate/hydroxypyruvate reductase A [EC:1.1.1.79 1.1.1.81] [KO:K12972] [EC:1.1.1.81 1.1.1.79]
D-isomer specific 2-hydroxyacid dehydrogenase; K12972 gyoxylate/hydroxypyruvate reductase A [EC:1.1.1.79 1.1.1.81] [KO:K12972] [EC:1.1.1.81 1.1.1.79]
2-amino-3-ketobutyrate CoA ligase; K00639 glycine C-acetyltransferase [EC:2.3.1.29] [KO:K00639] [EC:2.3.1.29]
tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
amine oxidase; FAD dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
amine oxidase (flavin-containing); K00274 monoamine oxidase [EC:1.4.3.4] [KO:K00274] [EC:1.4.3.4]
glycine dehydrogenase; K00281 glycine dehydrogenase [EC:1.4.4.2] [KO:K00281] [EC:1.4.4.2]
gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
dihydrolipoamide dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
dihydrolipoamide dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
dihydrolipoamide dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
dihydrolipoamide dehydrogenase; K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [KO:K00382] [EC:1.8.1.4]
CDP-diacylglycerol--serine O-phosphatidyltransferase; K00998 phosphatidylserine synthase [EC:2.7.8.8] [KO:K00998] [EC:2.7.8.8]
Rieske (2Fe-2S) domain-containing protein; K00499 choline monooxygenase [EC:1.14.15.7] [KO:K00499] [EC:1.14.15.7]
choline dehydrogenase; K00108 choline dehydrogenase [EC:1.1.99.1] [KO:K00108] [EC:1.1.99.1]
glucose-methanol-choline oxidoreductase; K00108 choline dehydrogenase [EC:1.1.99.1] [KO:K00108] [EC:1.1.99.1]
betaine aldehyde dehydrogenase; K00130 betaine-aldehyde dehydrogenase [EC:1.2.1.8] [KO:K00130] [EC:1.2.1.8]
aldehyde dehydrogenase; K00130 betaine-aldehyde dehydrogenase [EC:1.2.1.8] [KO:K00130] [EC:1.2.1.8]
betaine-aldehyde dehydrogenase; K00130 betaine-aldehyde dehydrogenase [EC:1.2.1.8] [KO:K00130] [EC:1.2.1.8]
betaine-aldehyde dehydrogenase; K00130 betaine-aldehyde dehydrogenase [EC:1.2.1.8] [KO:K00130] [EC:1.2.1.8]
betaine-aldehyde dehydrogenase; K00130 betaine-aldehyde dehydrogenase [EC:1.2.1.8] [KO:K00130] [EC:1.2.1.8]
sarcosine oxidase subunit alpha; K00302 sarcosine oxidase, subunit alpha [EC:1.5.3.1] [KO:K00302] [EC:1.5.3.1]
sarcosine oxidase subunit beta; K00303 sarcosine oxidase, subunit beta [EC:1.5.3.1] [KO:K00303] [EC:1.5.3.1]
FAD dependent oxidoreductase; K00303 sarcosine oxidase, subunit beta [EC:1.5.3.1] [KO:K00303] [EC:1.5.3.1]
sarcosine oxidase; K00305 sarcosine oxidase, subunit gamma [EC:1.5.3.1] [KO:K00305] [EC:1.5.3.1]
sarcosine oxidase; K00304 sarcosine oxidase, subunit delta [EC:1.5.3.1] [KO:K00304] [EC:1.5.3.1]
L-serine dehydratase 1; K01752 L-serine dehydratase [EC:4.3.1.17] [KO:K01752] [EC:4.3.1.17]
L-serine dehydratase 1; K01752 L-serine dehydratase [EC:4.3.1.17] [KO:K01752] [EC:4.3.1.17]
eutB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
pyridoxal-5'-phosphate-dependent enzyme subunit beta; K01754 threonine dehydratase [EC:4.3.1.19] [KO:K01754] [EC:4.3.1.19]
threonine dehydratase; K01754 threonine dehydratase [EC:4.3.1.19] [KO:K01754] [EC:4.3.1.19]
serine/threonine dehydratase; K01754 threonine dehydratase [EC:4.3.1.19] [KO:K01754] [EC:4.3.1.19]
amino acid aldolase or racemase-like protein; K01753 D-serine dehydratase [EC:4.3.1.18] [KO:K01753] [EC:4.3.1.18]
trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
tryptophan synthase subunit beta; K01696 tryptophan synthase beta chain [EC:4.2.1.20] [KO:K01696] [EC:4.2.1.20]
peptidase M24; K15783 ectoine hydrolase [KO:K15783]
succinylglutamate desuccinylase/aspartoacylase; K15784 N-alpha-acetyl-L-2,4-diaminobutyrate deacetylase [EC:3.5.1.-] [KO:K15784] [EC:3.5.1.-]
hypothetical protein; K15785 L-2,4-diaminobutyrate transaminase [EC:2.6.1.-] [KO:K15785] [EC:2.6.1.-]
succinate-semialdehyde dehydrogenase (NAD(P)(+)); K15786 aspartate-semialdehyde dehydrogenase [EC:1.2.1.-] [KO:K15786] [EC:1.2.1.-]
Compound
C00011  
CO2
C00014  
NH3
C00022  
Pyruvate
C00037  
Glycine
C00048  
Glyoxylate
C00049  
L-Aspartate
C00065  
L-Serine
C00078  
L-Tryptophan
C00097  
L-Cysteine
C00101  
Tetrahydrofolate
C00109  
2-Oxobutanoate
C00114  
Choline
C00143  
5,10-Methylenetetrahydrofolate
C00168  
Hydroxypyruvate
C00188  
L-Threonine
C00197  
3-Phospho-D-glycerate
C00213  
Sarcosine
C00258  
D-Glycerate
C00263  
L-Homoserine
C00300  
Creatine
C00430  
5-Aminolevulinate
C00441  
L-Aspartate 4-semialdehyde
C00546  
Methylglyoxal
C00576  
Betaine aldehyde
C00581  
Guanidinoacetate
C00631  
2-Phospho-D-glycerate
C00719  
Betaine
C00740  
D-Serine
C00986  
1,3-Diaminopropane
C01005  
O-Phospho-L-serine
C01026  
N,N-Dimethylglycine
C01102  
O-Phospho-L-homoserine
C01242  
S-Aminomethyldihydrolipoylprotein
C01726  
D-Lombricine
C01888  
Aminoacetone
C02051  
Lipoylprotein
C02291  
L-Cystathionine
C02737  
Phosphatidylserine
C02855  
N-Phospho-D-lombricine
C02972  
Dihydrolipoylprotein
C03082  
4-Phospho-L-aspartate
C03194  
(R)-1-Aminopropan-2-ol
C03232  
3-Phosphonooxypyruvate
C03283  
L-2,4-Diaminobutanoate
C03508  
L-2-Amino-3-oxobutanoic acid
C05235  
Hydroxyacetone
C05519  
L-Allothreonine
C06231  
Ectoine
C06442  
N-gamma-Acetyldiaminobutyrate
C16432  
5-Hydroxyectoine
C19929  
N-alpha-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
KO pathway
 
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