KEGG   PATHWAY: bcu02020
Entry
bcu02020                    Pathway                                
Name
Two-component system - Bacillus cereus AH820
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
bcu02020  Two-component system
bcu02020

Other DBs
GO: 0000160
Organism
Bacillus cereus AH820 [GN:bcu]
Gene
BCAH820_4703  phoR; sensory box histidine kinase PhoR [KO:K07636] [EC:2.7.13.3]
BCAH820_4704  phoP; DNA-binding response regulator PhoP [KO:K07658]
BCAH820_2999  alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
BCAH820_4426  alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
BCAH820_0770  putative phosphate ABC transporter, phosphate-binding protein [KO:K02040]
BCAH820_4292  phoX; phosphate ABC transporter, phosphate-binding protein [KO:K02040]
BCAH820_1756  A-type flagellin [KO:K02406]
BCAH820_1757  A-type flagellin [KO:K02406]
BCAH820_1725  putative chemotaxis protein MotA [KO:K02556]
BCAH820_4625  chemotaxis protein MotA [KO:K02556]
BCAH820_0818  kdpD; sensor histidine kinase KdpD [KO:K07646] [EC:2.7.13.3]
BCAH820_0815  kdpA; potassium-transporting ATPase, A subunit [KO:K01546]
BCAH820_0816  kdpB; potassium-transporting ATPase, B subunit [KO:K01547] [EC:7.2.2.6]
BCAH820_0817  kdpC; potassium-transporting ATPase, C subunit [KO:K01548]
BCAH820_1570  resE; sensor histidine kinase ResE [KO:K07651] [EC:2.7.13.3]
BCAH820_1569  resD; DNA-binding response regulator ResD [KO:K07775]
BCAH820_3961  ctaA; cytochrome aa3 controlling protein [KO:K02259] [EC:1.17.99.9]
BCAH820_5571  yycG; sensory box histidine kinase YycG [KO:K07652] [EC:2.7.13.3]
BCAH820_5572  yycF; DNA-binding response regulator YycF [KO:K07668]
BCAH820_0001  dnaA; chromosomal replication initiator protein DnaA [KO:K02313]
BCAH820_5201  bacitracin export ATP-binding protein BceA [KO:K11631]
BCAH820_4946  efflux ABC transporter, ATP-binding protein [KO:K11631]
BCAH820_4945  efflux ABC transporter, permease protein [KO:K11632]
BCAH820_5202  ABC transporter, permease component [KO:K11632]
BCAH820_5199  sensor histidine kinase [KO:K19081] [EC:2.7.13.3]
BCAH820_5200  DNA-binding response regulator [KO:K19082]
BCAH820_1461  dltA; D-alanine--poly(phosphoribitol) ligase, subunit 1 [KO:K03367] [EC:6.1.1.13]
BCAH820_1460  dltB; D-alanyl-lipoteichoic acid biosynthesis protein DltB [KO:K03739]
BCAH820_1459  dltC; D-alanine--poly(phosphoribitol) ligase, subunit 2 [KO:K14188] [EC:6.1.1.13]
BCAH820_1458  dltD; D-alanyl-lipoteichoic acid biosynthesis protein DltD [KO:K03740]
BCAH820_2852  dltD2; dltD protein [KO:K03740]
BCAH820_1558  putative lysylphosphatidylglycerol synthetase MprF [KO:K14205] [EC:2.3.2.3]
BCAH820_2615  sensor histidine kinase [KO:K11633] [EC:2.7.13.3]
BCAH820_4949  sensor histidine kinase [KO:K11633] [EC:2.7.13.3]
BCAH820_2614  DNA-binding response regulator [KO:K11634]
BCAH820_4952  ABC transporter, ATP-binding protein [KO:K11635]
BCAH820_2620  ABC transporter, ATP-binding protein [KO:K11635]
BCAH820_2033  putative membrane protein [KO:K11636]
BCAH820_4950  putative membrane protein [KO:K11636]
BCAH820_4951  putative permease [KO:K11636]
BCAH820_4953  putative membrane protein [KO:K11636]
BCAH820_2621  efflux ABC transporter, permease protein [KO:K11636]
BCAH820_0627  DNA-binding response regulator [KO:K14983]
BCAH820_3208  sensor protein vanSB [KO:K18345] [EC:2.7.13.3]
BCAH820_3209  alkaline phosphatase synthesis transcriptional regulatory proteinphoP [KO:K18344]
BCAH820_5144  DNA-binding response regulator [KO:K18344]
BCAH820_4961  D-alanyl-D-alanine carboxypeptidase family protein [KO:K07260] [EC:3.4.17.14]
BCAH820_4626  D-alanyl-D-alanine carboxypeptidase family protein [KO:K07260] [EC:3.4.17.14]
BCAH820_2541  D-alanyl-D-alanine carboxypeptidase family protein [KO:K07260] [EC:3.4.17.14]
BCAH820_2101  D-alanyl-D-alanine carboxypeptidase family protein [KO:K07260] [EC:3.4.17.14]
BCAH820_2241  sensor histidine kinase [KO:K18940] [EC:2.7.13.3]
BCAH820_2240  DNA-binding response regulator [KO:K18941]
BCAH820_3143  sporulation kinase [KO:K02491] [EC:2.7.13.3]
BCAH820_1429  kinB1; sporulation kinase B [KO:K07697] [EC:2.7.13.3]
BCAH820_2661  kinB2; sporulation kinase B [KO:K07697] [EC:2.7.13.3]
BCAH820_4025  kinB3; sporulation kinase B [KO:K07697] [EC:2.7.13.3]
BCAH820_5020  kinase-associated protein B [KO:K06347]
BCAH820_1424  sensor histidine kinase KinD [KO:K13532] [EC:2.7.13.3]
BCAH820_5429  spo0F; sporulation initiation phosphotransferase F [KO:K02490]
BCAH820_4521  putative sporulation initiation phosphotransferase [KO:K06375] [EC:2.7.-.-]
BCAH820_4192  spo0A; stage 0 sporulation protein A [KO:K07699]
BCAH820_1004  sensor histidine kinase [KO:K11637] [EC:2.7.13.3]
BCAH820_1005  response regulator [KO:K11638]
BCAH820_0632  sensory box histidine kinase [KO:K11614] [EC:2.7.13.3]
BCAH820_0633  response regulator [KO:K11615]
BCAH820_1848  malS; malate oxidoreductase (oxaloacetate-decarboxylating) [KO:K00027] [EC:1.1.1.38]
BCAH820_0635  putative malate dehydrogenase [KO:K00027] [EC:1.1.1.38]
BCAH820_4718  putative malate dehydrogenase [KO:K00027] [EC:1.1.1.38]
BCAH820_0634  citrate cation symporter family [KO:K11616]
BCAH820_5537  sensor histidine kinase LytS [KO:K07704] [EC:2.7.13.3]
BCAH820_5536  response regulator LytR [KO:K07705]
BCAH820_5535  putative holin [KO:K05338]
BCAH820_5534  putative membrane protein [KO:K05339]
BCAH820_3005  histidine kinase domain protein [KO:K07706] [EC:2.7.13.3]
BCAH820_3006  response regulator [KO:K07707]
BCAH820_2158  narG; respiratory nitrate reductase, alpha subunit [KO:K00370] [EC:1.7.5.1 1.7.99.-]
BCAH820_2159  narH; respiratory nitrate reductase, beta subunit [KO:K00371] [EC:1.7.5.1 1.7.99.-]
BCAH820_2161  narI; respiratory nitrate reductase, gamma subunit [KO:K00374] [EC:1.7.5.1 1.7.99.-]
BCAH820_2160  narJ; nitrate reductase molybdenum cofactor assembly chaperone [KO:K00373]
BCAH820_5445  sensor histidine kinase [KO:K07778] [EC:2.7.13.3]
BCAH820_5444  DNA-binding response regulator [KO:K07693]
BCAH820_2998  fatty acid desaturase [KO:K10255] [EC:1.14.19.23 1.14.19.45]
BCAH820_1530  sensor histidine kinase [KO:K11617] [EC:2.7.13.3]
BCAH820_1531  DNA-binding response regulator [KO:K11618]
BCAH820_1527  conserved hypothetical protein [KO:K11619]
BCAH820_1529  conserved hypothetical protein [KO:K11622]
BCAH820_B0084  cpaB; Flp pilus assembly protein CpaB [KO:K02279]
BCAH820_B0086  bacterial type II/IV secretion system protein [KO:K02283] [EC:7.4.2.8]
BCAH820_B0087  membrane protein, putative [KO:K12510]
BCAH820_3713  glnA; glutamine synthetase, type I [KO:K01915] [EC:6.3.1.2]
BCAH820_2320  atoD; acetate CoA-transferase, subunit A [KO:K01034] [EC:2.8.3.8 2.8.3.9]
BCAH820_2321  CoA-transferase, beta subunit [KO:K01035] [EC:2.8.3.8 2.8.3.9]
BCAH820_3329  putative membrane protein [KO:K02106]
BCAH820_5437  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BCAH820_3638  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BCAH820_4043  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BCAH820_3597  C4-dicarboxylate transporter [KO:K11103]
BCAH820_5227  sigL; RNA polymerase sigma-54 factor [KO:K03092]
BCAH820_1071  methyltransferase, CheR family [KO:K00575] [EC:2.1.1.80]
BCAH820_1732  cheR; chemotaxis protein methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
BCAH820_0614  methyl-accepting chemotaxis protein [KO:K03406]
BCAH820_2043  methyl-accepting chemotaxis protein [KO:K03406]
BCAH820_3282  methyl-accepting chemotaxis protein [KO:K03406]
BCAH820_0405  methyl-accepting chemotaxis protein [KO:K03406]
BCAH820_0422  methyl-accepting chemotaxis protein [KO:K03406]
BCAH820_0739  methyl-accepting chemotaxis protein [KO:K03406]
BCAH820_0631  methyl-accepting chemotaxis protein [KO:K03406]
BCAH820_5149  chemotaxis signal transducer [KO:K03406]
BCAH820_5150  chemotaxis signal transducer [KO:K03406]
BCAH820_5124  methyl-accepting chemotaxis protein [KO:K03406]
BCAH820_5184  methyl-accepting chemotaxis protein [KO:K03406]
BCAH820_1728  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
BCAH820_1072  sensor histidine kinase/response regulator [KO:K03407] [EC:2.7.13.3]
BCAH820_1727  chemotaxis response regulator [KO:K03413]
BCAH820_1754  chemotaxis protein CheV [KO:K03415]
BCAH820_3163  sensor histidine kinase [KO:K07717] [EC:2.7.13.3]
BCAH820_1849  sensor histidine kinase [KO:K07717] [EC:2.7.13.3]
BCAH820_1850  response regulator [KO:K07719]
BCAH820_3162  response regulator [KO:K07719]
BCAH820_3164  glsA2; glutaminase A [KO:K01425] [EC:3.5.1.2]
BCAH820_0480  glsA1; glutaminase A [KO:K01425] [EC:3.5.1.2]
BCAH820_3165  sodium/alanine symporter family protein [KO:K11626]
BCAH820_4614  DNA-binding response regulator [KO:K07720]
BCAH820_5313  cydA3; cytochrome d ubiquinol oxidase, subunit I [KO:K00425] [EC:7.1.1.7]
BCAH820_4914  cydA2; cytochrome d ubiquinol oxidase, subunit I [KO:K00425] [EC:7.1.1.7]
BCAH820_1978  cydA1; cytochrome d ubiquinol oxidase, subunit I [KO:K00425] [EC:7.1.1.7]
BCAH820_5314  putative cytochrome d ubiquinol oxidase, subunit II [KO:K00426] [EC:7.1.1.7]
BCAH820_4915  cydB2; cytochrome d ubiquinol oxidase, subunit II [KO:K00426] [EC:7.1.1.7]
BCAH820_3994  cytochrome d ubiquinol oxidase, subunit II-related protein [KO:K00426] [EC:7.1.1.7]
BCAH820_1979  cydB1; cytochrome d ubiquinol oxidase, subunit II [KO:K00426] [EC:7.1.1.7]
BCAH820_0451  low molecular weight phosphotyrosine protein phosphatase family protein [KO:K25307] [EC:3.1.3.48]
BCAH820_5359  UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
BCAH820_5289  UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
BCAH820_5362  UDP-glucose/GDP-mannose dehydrogenase family protein [KO:K02472] [EC:1.1.1.336]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
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  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
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Reference
PMID:15813739
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  Title
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Reference
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J Biol Chem 277:24155-61 (2002)
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  Title
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J Bacteriol 187:5723-31 (2005)
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Reference
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J Bacteriol 184:4161-7 (2002)
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Reference
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  Title
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Reference
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  Title
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Reference
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  Title
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Proc Natl Acad Sci U S A 101:13318-23 (2004)
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Reference
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  Title
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Reference
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Reference
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Reference
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  Title
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Reference
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  Title
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Reference
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Reference
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Reference
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  Title
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Reference
PMID:11889485
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  Title
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Arch Microbiol 177:313-21 (2002)
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Reference
PMID:12167640
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  Title
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
  Journal
J Biol Chem 277:39809-14 (2002)
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Reference
PMID:8550490
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  Title
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
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Reference
PMID:10940023
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  Title
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J Bacteriol 182:4822-8 (2000)
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Reference
PMID:11807079
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  Title
High genetic variability of the agr locus in Staphylococcus species.
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J Bacteriol 184:1180-6 (2002)
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Reference
PMID:8501030
  Authors
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  Title
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
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Reference
PMID:9220011
  Authors
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  Title
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Mol Microbiol 24:1049-60 (1997)
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Microbiology 153:667-75 (2007)
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Related
pathway
bcu00190  Oxidative phosphorylation
bcu00550  Peptidoglycan biosynthesis
bcu00910  Nitrogen metabolism
bcu02030  Bacterial chemotaxis
bcu02040  Flagellar assembly
bcu03070  Bacterial secretion system
KO pathway
ko02020   

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