KEGG   PATHWAY: bdi03440Help
Entry
bdi03440                    Pathway                                

Name
Homologous recombination - Brachypodium distachyon
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
bdi03440

All organismsOrtholog table
Module
RPA complex [PATH:bdi03440]
MRN complex [PATH:bdi03440]
BRCA1-associated genome surveillance complex (BASC) [PATH:bdi03440]
Other DBs
BSID: 
GO: 
Organism
Brachypodium distachyon [GN:bdi]
Gene
single-stranded DNA-binding protein, mitochondrial [KO:K03111]
DNA repair protein recA homolog 1, chloroplastic [KO:K03553]
DNA repair protein recA homolog 3, mitochondrial [KO:K03553]
DNA polymerase I A, chloroplastic-like [KO:K02335] [EC:2.7.7.7]
DNA polymerase I A, chloroplastic-like [KO:K02335] [EC:2.7.7.7]
ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
double-strand break repair protein MRE11 [KO:K10865]
double-strand break repair protein MRE11-like [KO:K10865]
nijmegen breakage syndrome 1 protein [KO:K10867]
serine/threonine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
BRCA1-associated RING domain protein 1-like [KO:K10683]
protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
BRCA1-associated RING domain protein 1-like [KO:K10683]
Fanconi anemia group J protein homolog [KO:K15362] [EC:3.6.4.12]
BRCT domain-containing protein At4g02110 [KO:K10728]
DNA topoisomerase 2-binding protein 1 [KO:K10728]
uncharacterized LOC100846437 [KO:K20776]
BRCA1-A complex subunit BRE [KO:K12173]
lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
protein BREAST CANCER SUSCEPTIBILITY 2 homolog B-like [KO:K08775]
probable 26S proteasome complex subunit sem1-1 [KO:K10881]
probable 26S proteasome complex subunit sem1-1 [KO:K10881]
uncharacterized LOC100821436 [KO:K07466]
uncharacterized LOC100821223 [KO:K07466]
replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
uncharacterized protein At4g28440 [KO:K07466]
uncharacterized protein At4g28440-like [KO:K07466]
replication protein A 70 kDa DNA-binding subunit C-like [KO:K07466]
replication protein A 70 kDa DNA-binding subunit C-like [KO:K07466]
uncharacterized protein At4g28440-like [KO:K07466]
replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
replication protein A 70 kDa DNA-binding subunit-like [KO:K07466]
replication protein A 32 kDa subunit A-like [KO:K10739]
replication protein A 32 kDa subunit B-like [KO:K10739]
replication protein A 14 kDa subunit [KO:K10740]
replication protein A 14 kDa subunit-like [KO:K10740]
DNA repair protein RAD51 homolog B-like [KO:K04482]
DNA repair protein RAD51 homolog A [KO:K04482]
DNA repair protein RAD51 homolog 2 [KO:K10869]
DNA repair protein RAD51 homolog 3 [KO:K10870]
DNA repair protein RAD51 homolog 4 [KO:K10871]
DNA repair protein XRCC2 homolog [KO:K10879]
DNA repair protein XRCC3 homolog [KO:K10880]
DNA repair and recombination protein RAD54 [KO:K10875] [EC:3.6.4.-]
SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:3.6.4.-]
SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:3.6.4.-]
SNF2 domain-containing protein CLASSY 1-like [KO:K10875] [EC:3.6.4.-]
SNF2 domain-containing protein CLASSY 1-like [KO:K10875] [EC:3.6.4.-]
protein chromatin remodeling 35-like [KO:K10875] [EC:3.6.4.-]
protein chromatin remodeling 35-like [KO:K10875] [EC:3.6.4.-]
protein chromatin remodeling 35-like [KO:K10875] [EC:3.6.4.-]
protein chromatin remodeling 35-like [KO:K10875] [EC:3.6.4.-]
DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
DNA polymerase delta small subunit [KO:K02328]
protein IWS1 homolog A [KO:K03504]
DNA polymerase delta subunit 4-like [KO:K03505]
uncharacterized LOC100836085 [KO:K03505]
ATP-dependent DNA helicase Q-like 4A [KO:K10901] [EC:3.6.4.12]
ATP-dependent DNA helicase Q-like 1 [KO:K10901] [EC:3.6.4.12]
ATP-dependent DNA helicase Q-like 3 [KO:K10901] [EC:3.6.4.12]
TOP3A; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.99.1.2]
DNA topoisomerase 3-beta [KO:K03165] [EC:5.99.1.2]
crossover junction endonuclease MUS81-like [KO:K08991] [EC:3.1.22.-]
crossover junction endonuclease MUS81-like [KO:K08991] [EC:3.1.22.-]
crossover junction endonuclease EME1-like [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

DBGET integrated database retrieval system