KEGG   PATHWAY: bdi03440Help
Entry
bdi03440                    Pathway                                
Name
Homologous recombination - Brachypodium distachyon
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
bdi03440

All organismsOrtholog table
Module
DNA polymerase III complex, bacteria [PATH:bdi03440]
RPA complex [PATH:bdi03440]
MRN complex [PATH:bdi03440]
MRX complex [PATH:bdi03440]
BRCA1-associated genome surveillance complex (BASC) [PATH:bdi03440]
Other DBs
BSID: 
GO: 
Organism
Brachypodium distachyon [GN:bdi]
Gene
single-stranded DNA-binding protein; K03111 single-strand DNA-binding protein [KO:K03111]
DNA repair protein recA homolog 1; K03553 recombination protein RecA [KO:K03553]
DNA repair protein recA homolog 3; K03553 recombination protein RecA [KO:K03553]
uncharacterized LOC100823216; K02335 DNA polymerase I [EC:2.7.7.7] [KO:K02335] [EC:2.7.7.7]
uncharacterized LOC100833898; K02335 DNA polymerase I [EC:2.7.7.7] [KO:K02335] [EC:2.7.7.7]
ATP-dependent DNA helicase recG-like; K03655 ATP-dependent DNA helicase RecG [EC:3.6.4.12] [KO:K03655] [EC:3.6.4.12]
DNA repair protein RAD50-like; K10866 DNA repair protein RAD50 [EC:3.6.-.-] [KO:K10866] [EC:3.6.-.-]
double-strand break repair protein MRE11-like; K10865 double-strand break repair protein MRE11 [KO:K10865]
uncharacterized LOC100824411; K10867 nijmegen breakage syndrome protein 1 [KO:K10867]
uncharacterized LOC100822424; K07466 replication factor A1 [KO:K07466]
replication protein A 70 kDa DNA-binding subunit-like; K07466 replication factor A1 [KO:K07466]
replication protein A 70 kDa DNA-binding subunit-like; K07466 replication factor A1 [KO:K07466]
replication protein A 70 kDa DNA-binding subunit-like; K07466 replication factor A1 [KO:K07466]
replication protein A 70 kDa DNA-binding subunit-like; K07466 replication factor A1 [KO:K07466]
uncharacterized LOC100842852; K07466 replication factor A1 [KO:K07466]
uncharacterized LOC100821436; K07466 replication factor A1 [KO:K07466]
uncharacterized LOC100821223; K07466 replication factor A1 [KO:K07466]
uncharacterized LOC100839862; K07466 replication factor A1 [KO:K07466]
replication protein A 32 kDa subunit-like; K10739 replication factor A2 [KO:K10739]
uncharacterized LOC100837028; K10739 replication factor A2 [KO:K10739]
replication factor A protein 2-like; K10739 replication factor A2 [KO:K10739]
uncharacterized LOC100829480; K10740 replication factor A3 [KO:K10740]
DNA repair protein RAD51 homolog B-like; K04482 DNA repair protein RAD51 [KO:K04482]
DNA repair protein RAD51 homolog B-like; K04482 DNA repair protein RAD51 [KO:K04482]
uncharacterized LOC100832537; K08775 breast cancer 2 susceptibility protein [KO:K08775]
probable 26S proteasome complex subunit sem1-1-like; K10881 26 proteasome complex subunit DSS1 [KO:K10881]
probable 26S proteasome complex subunit sem1-1-like; K10881 26 proteasome complex subunit DSS1 [KO:K10881]
DNA repair protein RAD51 homolog 2-like; K10869 RAD51-like protein 1 [KO:K10869]
DNA repair protein RAD51 homolog 3-like; K10870 RAD51-like protein 2 [KO:K10870]
DNA repair protein RAD51 homolog 4-like; K10871 RAD51-like protein 3 [KO:K10871]
DNA repair protein XRCC2 homolog; K10879 DNA-repair protein XRCC2 [KO:K10879]
DNA repair protein XRCC3 homolog; K10880 DNA-repair protein XRCC3 [KO:K10880]
DNA repair and recombination protein RAD54-like; K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] [KO:K10875] [EC:3.6.4.-]
uncharacterized LOC100842951; K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] [KO:K10875] [EC:3.6.4.-]
uncharacterized LOC100831563; K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] [KO:K10875] [EC:3.6.4.-]
uncharacterized LOC100833676; K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] [KO:K10875] [EC:3.6.4.-]
uncharacterized LOC100839149; K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] [KO:K10875] [EC:3.6.4.-]
transcriptional regulator ATRX homolog; K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] [KO:K10875] [EC:3.6.4.-]
helicase ARIP4-like; K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] [KO:K10875] [EC:3.6.4.-]
uncharacterized LOC100846678; K10875 DNA repair and recombination protein RAD54 and RAD54-like protein [EC:3.6.4.-] [KO:K10875] [EC:3.6.4.-]
DNA polymerase delta catalytic subunit-like; K02327 DNA polymerase delta subunit 1 [EC:2.7.7.7] [KO:K02327] [EC:2.7.7.7]
DNA polymerase delta small subunit-like; K02328 DNA polymerase delta subunit 2 [KO:K02328]
uncharacterized LOC100831421; K03504 DNA polymerase delta subunit 3 [KO:K03504]
DNA polymerase delta subunit 4-like; K03505 DNA polymerase delta subunit 4 [KO:K03505]
uncharacterized LOC100827592; K03505 DNA polymerase delta subunit 4 [KO:K03505]
ATP-dependent DNA helicase Q-like 4A-like; K10901 bloom syndrome protein [EC:3.6.4.12] [KO:K10901] [EC:3.6.4.12]
ATP-dependent DNA helicase Q-like 1-like; K10901 bloom syndrome protein [EC:3.6.4.12] [KO:K10901] [EC:3.6.4.12]
ATP-dependent DNA helicase Q-like 3-like; K10901 bloom syndrome protein [EC:3.6.4.12] [KO:K10901] [EC:3.6.4.12]
TOP3A; topoisomerase (DNA) III alpha [KO:K03165] [EC:5.99.1.2]
DNA topoisomerase 3-beta-1-like; K03165 DNA topoisomerase III [EC:5.99.1.2] [KO:K03165] [EC:5.99.1.2]
crossover junction endonuclease mus81-like; K08991 crossover junction endonuclease MUS81 [EC:3.1.22.-] [KO:K08991] [EC:3.1.22.-]
uncharacterized LOC100834151; K10882 crossover junction endonuclease EME1 [EC:3.1.22.-] [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 
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