KEGG   PATHWAY: bfo00030
Entry
bfo00030                    Pathway                                
Name
Pentose phosphate pathway - Branchiostoma floridae (Florida lancelet)
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
Pathway map
bfo00030  Pentose phosphate pathway
bfo00030

Module
bfo_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:bfo00030]
bfo_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:bfo00030]
bfo_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:bfo00030]
bfo_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:bfo00030]
Other DBs
GO: 0006098
Organism
Branchiostoma floridae (Florida lancelet) [GN:bfo]
Gene
118418022  glucose-6-phosphate isomerase-like [KO:K01810] [EC:5.3.1.9]
118415985  glucose-6-phosphate 1-dehydrogenase-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
118417749  6-phosphogluconolactonase-like [KO:K01057] [EC:3.1.1.31]
118418047  GDH/6PGL endoplasmic bifunctional protein-like [KO:K13937] [EC:1.1.1.47 3.1.1.31]
118430769  6-phosphogluconate dehydrogenase, decarboxylating-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
118407507  ribulose-phosphate 3-epimerase-like [KO:K01783] [EC:5.1.3.1]
118415914  transketolase-like protein 2 isoform X1 [KO:K00615] [EC:2.2.1.1]
118406667  transaldolase-like [KO:K00616] [EC:2.2.1.2]
118413185  ribose-5-phosphate isomerase-like [KO:K01807] [EC:5.3.1.6]
118426408  sedoheptulokinase-like [KO:K11214] [EC:2.7.1.14]
118406350  deoxyribose-phosphate aldolase-like [KO:K01619] [EC:4.1.2.4]
118418618  ribokinase-like isoform X1 [KO:K00852] [EC:2.7.1.15]
118431295  phosphoglucomutase-1-like [KO:K01835] [EC:5.4.2.2]
118419770  phosphoglucomutase-2-like [KO:K15779] [EC:5.4.2.2 5.4.2.7]
118418997  ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
118415670  regucalcin-like [KO:K01053] [EC:3.1.1.17]
118407281  regucalcin-like isoform X1 [KO:K01053] [EC:3.1.1.17]
118419006  regucalcin-like isoform X1 [KO:K01053] [EC:3.1.1.17]
118419008  regucalcin-like [KO:K01053] [EC:3.1.1.17]
118419417  regucalcin-like [KO:K01053] [EC:3.1.1.17]
118410307  probable gluconokinase [KO:K00851] [EC:2.7.1.12]
118415989  glycerate kinase-like [KO:K11529] [EC:2.7.1.165]
118425659  fructose-bisphosphate aldolase-like isoform X1 [KO:K01623] [EC:4.1.2.13]
118409841  fructose-1,6-bisphosphatase 1-like isoform X1 [KO:K03841] [EC:3.1.3.11]
118405158  ATP-dependent 6-phosphofructokinase, muscle type-like [KO:K00850] [EC:2.7.1.11]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00085  D-Fructose 6-phosphate
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00354  D-Fructose 1,6-bisphosphate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01182  D-Ribulose 1,5-bisphosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C02076  Sedoheptulose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
Related
pathway
bfo00010  Glycolysis / Gluconeogenesis
bfo00040  Pentose and glucuronate interconversions
bfo00052  Galactose metabolism
bfo00230  Purine metabolism
bfo00240  Pyrimidine metabolism
bfo00340  Histidine metabolism
bfo00630  Glyoxylate and dicarboxylate metabolism
bfo00750  Vitamin B6 metabolism
KO pathway
ko00030   

DBGET integrated database retrieval system