KEGG   PATHWAY: bhy00030
Entry
bhy00030                    Pathway                                
Name
Pentose phosphate pathway - Brachyspira hyodysenteriae WA1
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
Pathway map
bhy00030  Pentose phosphate pathway
bhy00030

Module
bhy_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:bhy00030]
bhy_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:bhy00030]
bhy_M00061  D-Glucuronate degradation, D-glucuronate => pyruvate + D-glyceraldehyde 3P [PATH:bhy00030]
Other DBs
GO: 0006098
Organism
Brachyspira hyodysenteriae WA1 [GN:bhy]
Gene
BHWA1_01137  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
BHWA1_00002  rpe; ribulose-phosphate 3-epimerase [KO:K01783] [EC:5.1.3.1]
BHWA1_00091  tkt; Transketolase N-terminal subunit [KO:K00615] [EC:2.2.1.1]
BHWA1_00092  tkt'; Transketolase, pyridine binding subunit [KO:K00615] [EC:2.2.1.1]
BHWA1_01968  transaldolase [KO:K00616] [EC:2.2.1.2]
BHWA1_01037  rplB; ribose-5-phosphate isomerase B [KO:K01808] [EC:5.3.1.6]
BHWA1_01546  deoC; Deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]
BHWA1_02311  rbsK; ribokinase [KO:K00852] [EC:2.7.1.15]
BHWA1_02377  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
BHWA1_02494  prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
BHWA1_02238  eda; 2-keto-3-deoxy-6-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
BHWA1_00517  kdgK; 2-keto-3-deoxygluconate kinase [KO:K00874] [EC:2.7.1.45]
BHWA1_01769  fbaA; fruktose-biphosphate aldolase [KO:K01624] [EC:4.1.2.13]
BHWA1_00731  fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
BHWA1_01708  fructose-1,6-bisphosphatase [KO:K04041] [EC:3.1.3.11]
BHWA1_02459  pfkA; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00085  D-Fructose 6-phosphate
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00354  D-Fructose 1,6-bisphosphate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01182  D-Ribulose 1,5-bisphosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C02076  Sedoheptulose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
Related
pathway
bhy00010  Glycolysis / Gluconeogenesis
bhy00040  Pentose and glucuronate interconversions
bhy00052  Galactose metabolism
bhy00230  Purine metabolism
bhy00240  Pyrimidine metabolism
bhy00340  Histidine metabolism
bhy00630  Glyoxylate and dicarboxylate metabolism
bhy00750  Vitamin B6 metabolism
KO pathway
ko00030   

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