KEGG   PATHWAY: bmn00290Help
Entry
bmn00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Burkholderia mallei NCTC 10247
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
Valine, leucine and isoleucine biosynthesis
bmn00290

All organismsOrtholog table
Module
Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:bmn00290]
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:bmn00290]
Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:bmn00290]
Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:bmn00290]
Other DBs
Organism
Burkholderia mallei NCTC 10247 [GN:bmn]
Gene
ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
tdcB; threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
threonine dehydratase; K01754 threonine dehydratase [EC:4.3.1.19] [KO:K01754] [EC:4.3.1.19]
serine/threonine dehydratase; K01754 threonine dehydratase [EC:4.3.1.19] [KO:K01754] [EC:4.3.1.19]
leuC; isopropylmalate isomerase large subunit [KO:K01703] [EC:4.2.1.35 4.2.1.33]
leuD; isopropylmalate isomerase small subunit [KO:K01704] [EC:4.2.1.35 4.2.1.33]
leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
ilvB; acetolactate synthase 3 catalytic subunit [KO:K01652] [EC:2.2.1.6]
acetolactate synthase; K01652 acetolactate synthase I/II/III large subunit [EC:2.2.1.6] [KO:K01652] [EC:2.2.1.6]
thiamine pyrophosphate protein; K01652 acetolactate synthase I/II/III large subunit [EC:2.2.1.6] [KO:K01652] [EC:2.2.1.6]
ilvH; acetolactate synthase 3 regulatory subunit [KO:K01653] [EC:2.2.1.6]
ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
putative ketol-acid reductoisomerase; K00053 ketol-acid reductoisomerase [EC:1.1.1.86] [KO:K00053] [EC:1.1.1.86]
ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
leuA-1; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00109  
2-Oxobutanoate
C00123  
L-Leucine
C00141  
3-Methyl-2-oxobutanoic acid
C00183  
L-Valine
C00188  
L-Threonine
C00233  
4-Methyl-2-oxopentanoate
C00407  
L-Isoleucine
C00671  
(S)-3-Methyl-2-oxopentanoic acid
C02226  
2-Methylmaleate
C02504  
alpha-Isopropylmalate
C02612  
(R)-2-Methylmalate
C02631  
2-Isopropylmaleate
C04181  
3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  
(2S)-2-Isopropyl-3-oxosuccinate
C04272  
(R)-2,3-Dihydroxy-3-methylbutanoate
C04411  
(2R,3S)-3-Isopropylmalate
C06006  
(S)-2-Aceto-2-hydroxybutanoate
C06007  
(R)-2,3-Dihydroxy-3-methylpentanoate
C06010  
(S)-2-Acetolactate
C06032  
D-erythro-3-Methylmalate
C14463  
(R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
KO pathway
 
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