| Entry |
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| Name |
Bacterial chemotaxis - Bacillus megaterium QM B1551
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| Description |
Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.
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| Class |
Cellular Processes; Cell motility
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| Pathway map |
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| Module |
| CheA-CheYBV (chemotaxis) two-component regulatory system [PATH: bmq02030] |
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| Other DBs |
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| Organism |
Bacillus megaterium QM B1551 [GN: bmq]
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| Gene |
| methyl-accepting chemotaxis protein; K03406 methyl-accepting chemotaxis protein [KO: K03406] | | methyl-accepting chemotaxis protein domain-containing protein; K03406 methyl-accepting chemotaxis protein [KO: K03406] | | rbsB; ribose ABC transporter ribose-binding protein RbsB [KO: K10439] | | two-component sensor histidine kinase/response regulator; K03407 two-component system, chemotaxis family, sensor kinase CheA [EC: 2.7.13.3] [KO: K03407] [EC: 2.7.13.3] | | cheA; chemotactic two-component sensor histidine kinase [KO: K03407] [EC: 2.7.13.3] | | cheW; chemotactic signal transduction protein [KO: K03408] | | cheY; chemotaxis protein CheY [KO: K03413] | | cheB; chemotactic two-component response regulator-glutamate methylesterase [KO: K03412] [EC: 3.1.1.61] | | signal transduction histidine kinase with CheB and CheR activity; K13924 two-component system, chemotaxis family, CheB/CheR fusion protein [EC: 2.1.1.80 3.1.1.61] [KO: K13924] [EC: 3.1.1.61 2.1.1.80] | | cheV; chemotaxis protein CheV [KO: K03415] | | cheD; chemoreceptor glutamine deamidase CheD [KO: K03411] [EC: 3.5.1.44] | | chemotaxis protein methyltransferase CheR; K00575 chemotaxis protein methyltransferase CheR [EC: 2.1.1.80] [KO: K00575] [EC: 2.1.1.80] | | | | fliG; flagellar motor switch protein FliG [KO: K02410] | | fliM; flagellar motor switch protein FliM [KO: K02416] | | fliN; flagellar motor switch protein FliN [KO: K02417] | | putative flagellar motor channel protein; K02556 chemotaxis protein MotA [KO: K02556] | | motA; chemotaxis protein MotA [KO: K02556] | | putative flagellar motor channel protein; K02557 chemotaxis protein MotB [KO: K02557] | | motB; chemotaxis protein MotB [KO: K02557] |
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| Compound |
| L-Aspartate | | Dipeptide | | D-Ribose | | D-Galactose | | Maltose | | DL-Serine |
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| Reference |
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| Authors |
Kristich CJ, Ordal GW. |
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| Title |
Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis. |
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| Journal |
J Biol Chem 277:25356-62 (2002) |
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| Reference |
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| Authors |
Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW. |
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| Title |
CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis. |
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| Journal |
Mol Microbiol 42:573-85 (2001) |
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| Reference |
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| Authors |
Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW. |
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| Title |
Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch. |
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| Journal |
J Biol Chem 278:48611-6 (2003) |
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| Reference |
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| Authors |
Szurmant H, Muff TJ, Ordal GW. |
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| Title |
Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade. |
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| Journal |
J Biol Chem 279:21787-92 (2004) |
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| Reference |
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| Authors |
Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M. |
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| Title |
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803. |
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| Journal |
Plant Cell Physiol 42:63-73 (2001) |
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| Reference |
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| Authors |
Darzins A. |
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| Title |
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY. |
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| Journal |
J Bacteriol 175:5934-44 (1993) |
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| Reference |
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| Authors |
Szurmant H, Ordal GW |
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| Title |
Diversity in chemotaxis mechanisms among the bacteria and archaea. |
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| Journal |
Microbiol Mol Biol Rev 68:301-19 (2004) |
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| Reference |
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| Authors |
Rao CV, Glekas GD, Ordal GW |
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| Title |
The three adaptation systems of Bacillus subtilis chemotaxis. |
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| Journal |
Trends Microbiol 16:480-7 (2008) |
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| Reference |
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| Authors |
Muff TJ, Ordal GW |
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| Title |
The diverse CheC-type phosphatases: chemotaxis and beyond. |
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| Journal |
Mol Microbiol 70:1054-61 (2008) |
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| Reference |
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| Authors |
Miller LD, Russell MH, Alexandre G |
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| Title |
Diversity in bacterial chemotactic responses and niche adaptation. |
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| Journal |
Adv Appl Microbiol 66:53-75 (2009) |
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| KO pathway |
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