KEGG   PATHWAY: bmw03440Help
Entry
bmw03440                    Pathway                                

Name
Homologous recombination - Brucella melitensis NI
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
bmw03440  Homologous recombination
bmw03440

Ortholog table
Module
bmw_M00260  DNA polymerase III complex, bacteria [PATH:bmw03440]
Other DBs
BSID: 597839
GO: 0000724
Organism
Brucella melitensis NI [GN:bmw]
Gene
BMNI_I1233  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
BMNI_I1076  single-strand binding protein [KO:K03111]
BMNI_I0003  recombination protein F [KO:K03629]
BMNI_I0664  DNA repair protein RecO [KO:K03584]
BMNI_I0031  recombination protein RecR [KO:K06187]
BMNI_I1170  recA protein [KO:K03553]
BMNI_I0123  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
BMNI_I1637  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
BMNI_I1636  Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
BMNI_I1638  Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
BMNI_II0547  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
BMNI_I0815  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
BMNI_I0002  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
BMNI_I0033  DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
BMNI_I1955  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
BMNI_I0971  DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
BMNI_II0949  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
BMNI_II0587  DNA polymerase III, epsilon chain [KO:K02342] [EC:2.7.7.7]
BMNI_I1972  DNA polymerase iii, epsilon chain [KO:K02342] [EC:2.7.7.7]
BMNI_I0686  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
BMNI_I1726  primosome assembly protein PriA [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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