KEGG   PATHWAY: bmy04142Help
Entry
bmy04142                    Pathway                                

Name
Lysosome - Brugia malayi (filaria)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Lysosome
bmy04142

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Other DBs
BSID: 
GO: 
Organism
Brugia malayi (filaria) [GN:bmy]
Gene
vacuolar proton pump [KO:K02154]
vacuolar proton pump [KO:K02154]
Vacuolar h atpase protein 16 [KO:K02146]
hypothetical protein [KO:K03662]
Vacuolar ATP synthase 16 kDa proteolipid subunit 1, putative [KO:K02155]
Vacuolar ATP synthase 16 kDa proteolipid subunit, putative [KO:K02155]
Vacuolar ATP synthase 21 kDa proteolipid subunit, putative [KO:K03661]
Serine carboxypeptidase F41C3.5 precursor [KO:K13289] [EC:3.4.16.5]
cathepsin B-like cysteine proteinase [KO:K01363] [EC:3.4.22.1]
aspartic protease BmAsp-2, identical [KO:K01379] [EC:3.4.23.5]
Cathepsin L-like precursor [KO:K01371] [EC:3.4.22.38]
Cathepsin L-like precursor [KO:K01365] [EC:3.4.22.15]
cathepsin Z-like cysteine proteinase [KO:K08568] [EC:3.4.18.1]
cathepsin Z-like cysteine proteinase [KO:K08568] [EC:3.4.18.1]
Peptidase C13 family protein [KO:K01369] [EC:3.4.22.34]
O-Glycosyl hydrolase family 30 protein [KO:K01201] [EC:3.2.1.45]
Glycosyl hydrolases family 2, sugar binding domain containing protein [KO:K01195] [EC:3.2.1.31]
Glycosyl hydrolase family 20, catalytic domain containing protein [KO:K12373] [EC:3.2.1.52]
manba-prov protein [KO:K01192] [EC:3.2.1.25]
lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
ab-hydrolase associated lipase region family protein [KO:K01052] [EC:3.1.1.13]
Lecithin:cholesterol acyltransferase family protein [KO:K06129] [EC:3.1.1.5]
Deoxyribonuclease II family protein [KO:K01158] [EC:3.1.22.1]
Deoxyribonuclease II family protein [KO:K01158] [EC:3.1.22.1]
Histidine acid phosphatase family protein [KO:K14410] [EC:3.1.3.2]
Histidine acid phosphatase family protein [KO:K14410] [EC:3.1.3.2]
Ser/Thr protein phosphatase family protein [KO:K14379] [EC:3.1.3.2]
N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase, putative [KO:K01444] [EC:3.5.1.26]
Saposin-like type B, region 1 family protein [KO:K12382]
Palmitoyl-protein thioesterase 1 precursor [KO:K01074] [EC:3.1.2.22]
LAMP family protein lmp-1 precursor [KO:K06528]
Tetraspanin family protein [KO:K06497]
CD36 family protein [KO:K12384]
ML domain containing protein [KO:K13443]
NRAMP-like transporter K11G12.4 [KO:K21398]
ABC transporter family protein [KO:K05656]
CLN3 protein [KO:K12389]
Probable clathrin heavy chain [KO:K04646]
gamma1-adaptin [KO:K12391]
Clathrin coat assembly protein AP47 [KO:K12393]
clathrin-associated protein [KO:K12393]
Clathrin coat assembly protein AP47 [KO:K12393]
clathrin-associated protein [KO:K12393]
adapter-related protein complex 1 sigma 1B subunit, putative [KO:K12394]
Adaptin N terminal region family protein [KO:K12396]
Adaptin [KO:K12396]
Adaptin [KO:K12396]
Adaptin N terminal region family protein [KO:K12397]
Adaptin or adaptin-related protein protein 7 [KO:K12398]
adaptin or adaptin-related protein protein 8 [KO:K12399]
Compound
C00002  
ATP
C00008  
ADP
C00159  
D-Mannose
C00275  
D-Mannose 6-phosphate
Reference
  Authors
Alberts B,  Johnson A, Lewis J, Raff M, Roberts K, Walter P
  Title
Molecular Biology of the Cell 4th ed.
  Journal
Garland Science (2002)
Reference
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
Reference
  Authors
Uchiyama Y.
  Title
[The analysis of a knockout mouse.] ( In Japanese)
  Journal
Cell Technology 25:1322-27 (2006)
Reference
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
Reference
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
KO pathway
 

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