KEGG   PATHWAY: bmy04142Help
Entry
bmy04142                    Pathway                                

Name
Lysosome - Brugia malayi (filaria)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Lysosome
bmy04142

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BSID: 
GO: 
Organism
Brugia malayi (filaria) [GN:bmy]
Gene
vacuolar proton pump; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
vacuolar proton pump; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
Vacuolar h atpase protein 16; K02146 V-type H+-transporting ATPase subunit d [KO:K02146]
hypothetical protein; K03662 V-type H+-transporting ATPase S1 subunit [KO:K03662]
Vacuolar ATP synthase 16 kDa proteolipid subunit 1; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
Vacuolar ATP synthase 16 kDa proteolipid subunit; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
Vacuolar ATP synthase 21 kDa proteolipid subunit; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [KO:K03661]
Serine carboxypeptidase F41C3.5 precursor; K13289 cathepsin A (carboxypeptidase C) [EC:3.4.16.5] [KO:K13289] [EC:3.4.16.5]
cathepsin B-like cysteine proteinase; K01363 cathepsin B [EC:3.4.22.1] [KO:K01363] [EC:3.4.22.1]
aspartic protease BmAsp-2; K01379 cathepsin D [EC:3.4.23.5] [KO:K01379] [EC:3.4.23.5]
Cathepsin L-like precursor; K01371 cathepsin K [EC:3.4.22.38] [KO:K01371] [EC:3.4.22.38]
Cathepsin L-like precursor; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
cathepsin Z-like cysteine proteinase; K08568 cathepsin X [EC:3.4.18.1] [KO:K08568] [EC:3.4.18.1]
cathepsin Z-like cysteine proteinase; K08568 cathepsin X [EC:3.4.18.1] [KO:K08568] [EC:3.4.18.1]
Peptidase C13 family protein; K01369 legumain [EC:3.4.22.34] [KO:K01369] [EC:3.4.22.34]
O-Glycosyl hydrolase family 30 protein; K01201 glucosylceramidase [EC:3.2.1.45] [KO:K01201] [EC:3.2.1.45]
Glycosyl hydrolases family 2; K01195 beta-glucuronidase [EC:3.2.1.31] [KO:K01195] [EC:3.2.1.31]
Glycosyl hydrolase family 20; K12373 hexosaminidase [EC:3.2.1.52] [KO:K12373] [EC:3.2.1.52]
manba-prov protein; K01192 beta-mannosidase [EC:3.2.1.25] [KO:K01192] [EC:3.2.1.25]
lysosomal alpha-mannosidase; K12311 lysosomal alpha-mannosidase [EC:3.2.1.24] [KO:K12311] [EC:3.2.1.24]
ab-hydrolase associated lipase region family protein; K01052 lysosomal acid lipase/cholesteryl ester hydrolase [EC:3.1.1.13] [KO:K01052] [EC:3.1.1.13]
Lecithin:cholesterol acyltransferase family protein; K06129 lysophospholipase III [EC:3.1.1.5] [KO:K06129] [EC:3.1.1.5]
Deoxyribonuclease II family protein; K01158 deoxyribonuclease II [EC:3.1.22.1] [KO:K01158] [EC:3.1.22.1]
Deoxyribonuclease II family protein; K01158 deoxyribonuclease II [EC:3.1.22.1] [KO:K01158] [EC:3.1.22.1]
N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase; K01444 N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26] [KO:K01444] [EC:3.5.1.26]
Saposin-like type B; K12382 saposin [KO:K12382]
Palmitoyl-protein thioesterase 1 precursor; K01074 palmitoyl-protein thioesterase [EC:3.1.2.22] [KO:K01074] [EC:3.1.2.22]
LAMP family protein lmp-1 precursor; K06528 lysosomal-associated membrane protein 1/2 [KO:K06528]
Tetraspanin family protein; K06497 CD63 antigen [KO:K06497]
CD36 family protein; K12384 lysosome membrane protein 2 [KO:K12384]
ML domain containing protein; K13443 Niemann-Pick C2 protein [KO:K13443]
NRAMP-like transporter K11G12.4; K12347 natural resistance-associated macrophage protein [KO:K12347]
ABC transporter family protein; K05656 ATP-binding cassette, subfamily B (MDR/TAP), member 9 [KO:K05656]
CLN3 protein; K12389 battenin [KO:K12389]
Probable clathrin heavy chain; K04646 clathrin heavy chain [KO:K04646]
gamma1-adaptin; K12391 AP-1 complex subunit gamma-1 [KO:K12391]
Clathrin coat assembly protein AP47; K12393 AP-1 complex subunit mu [KO:K12393]
clathrin-associated protein; K12393 AP-1 complex subunit mu [KO:K12393]
Clathrin coat assembly protein AP47; K12393 AP-1 complex subunit mu [KO:K12393]
clathrin-associated protein; K12393 AP-1 complex subunit mu [KO:K12393]
adapter-related protein complex 1 sigma 1B subunit; K12394 AP-1 complex subunit sigma 1/2 [KO:K12394]
Adaptin N terminal region family protein; K12396 AP-3 complex subunit delta-1 [KO:K12396]
Adaptin; K12396 AP-3 complex subunit delta-1 [KO:K12396]
Adaptin; K12396 AP-3 complex subunit delta-1 [KO:K12396]
Adaptin N terminal region family protein; K12397 AP-3 complex subunit beta [KO:K12397]
Adaptin or adaptin-related protein protein 7; K12398 AP-3 complex subunit mu [KO:K12398]
adaptin or adaptin-related protein protein 8; K12399 AP-3 complex subunit sigma [KO:K12399]
Compound
C00002  
ATP
C00008  
ADP
C00159  
D-Mannose
C00275  
D-Mannose 6-phosphate
Reference
  Authors
Alberts B,  Johnson A, Lewis J, Raff M, Roberts K, Walter P
  Title
Molecular Biology of the Cell 4th ed.
  Journal
Garland Science (2002)
Reference
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
Reference
  Authors
Uchiyama Y.
  Title
[The analysis of a knockout mouse.] ( In Japanese)
  Journal
Cell Technology 25:1322-27 (2006)
Reference
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
Reference
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
KO pathway
 

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