KEGG   PATHWAY: bmy04142Help
bmy04142                    Pathway                                

Lysosome - Brugia malayi (filaria)
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
bmy04142  Lysosome

Ortholog table
Other DBs
BSID: 99314
GO: 0005764
Brugia malayi (filaria) [GN:bmy]
Bm1_46445  vacuolar proton pump [KO:K02154]
Bm1_31340  vacuolar proton pump [KO:K02154]
Bm1_48215  Vacuolar h atpase protein 16 [KO:K02146]
Bm1_36575  hypothetical protein [KO:K03662]
Bm1_44370  Vacuolar ATP synthase 16 kDa proteolipid subunit 1, putative [KO:K02155]
Bm1_44375  Vacuolar ATP synthase 16 kDa proteolipid subunit, putative [KO:K02155]
Bm1_43140  Vacuolar ATP synthase 21 kDa proteolipid subunit, putative [KO:K03661]
Bm1_43130  Serine carboxypeptidase F41C3.5 precursor [KO:K13289] [EC:]
Bm1_33735  cathepsin B-like cysteine proteinase [KO:K01363] [EC:]
Bm1_12055  aspartic protease BmAsp-2, identical [KO:K01379] [EC:]
Bm1_13265  Cathepsin L-like precursor [KO:K01371] [EC:]
Bm1_20385  Cathepsin L-like precursor [KO:K01365] [EC:]
Bm1_56735  cathepsin Z-like cysteine proteinase [KO:K08568] [EC:]
Bm1_30360  cathepsin Z-like cysteine proteinase [KO:K08568] [EC:]
Bm1_50230  Peptidase C13 family protein [KO:K01369] [EC:]
Bm1_32350  O-Glycosyl hydrolase family 30 protein [KO:K01201] [EC:]
Bm1_53975  Glycosyl hydrolases family 2, sugar binding domain containing protein [KO:K01195] [EC:]
Bm1_15330  Glycosyl hydrolase family 20, catalytic domain containing protein [KO:K12373] [EC:]
Bm1_45340  manba-prov protein [KO:K01192] [EC:]
Bm1_32610  lysosomal alpha-mannosidase [KO:K12311] [EC:]
Bm1_21635  ab-hydrolase associated lipase region family protein [KO:K01052] [EC:]
Bm1_48320  Lecithin:cholesterol acyltransferase family protein [KO:K06129] [EC:]
Bm1_30865  Deoxyribonuclease II family protein [KO:K01158] [EC:]
Bm1_32760  Deoxyribonuclease II family protein [KO:K01158] [EC:]
Bm1_23365  Histidine acid phosphatase family protein [KO:K14410] [EC:]
Bm1_24820  Histidine acid phosphatase family protein [KO:K14410] [EC:]
Bm1_48715  Ser/Thr protein phosphatase family protein [KO:K14379] [EC:]
Bm1_03250  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase, putative [KO:K01444] [EC:]
Bm1_37185  Saposin-like type B, region 1 family protein [KO:K12382]
Bm1_51565  Palmitoyl-protein thioesterase 1 precursor [KO:K01074] [EC:]
Bm1_33020  LAMP family protein lmp-1 precursor [KO:K06528]
Bm1_47975  Tetraspanin family protein [KO:K06497]
Bm1_29920  CD36 family protein [KO:K12384]
Bm1_35600  ML domain containing protein [KO:K13443]
Bm1_40010  NRAMP-like transporter K11G12.4 [KO:K21398]
Bm1_15490  ABC transporter family protein [KO:K05656]
Bm1_48800  CLN3 protein [KO:K12389]
Bm1_21545  Probable clathrin heavy chain [KO:K04646]
Bm1_49090  gamma1-adaptin [KO:K12391]
Bm1_49745  Clathrin coat assembly protein AP47 [KO:K12393]
Bm1_56850  clathrin-associated protein [KO:K12393]
Bm1_56970  Clathrin coat assembly protein AP47 [KO:K12393]
Bm1_35845  clathrin-associated protein [KO:K12393]
Bm1_23720  adapter-related protein complex 1 sigma 1B subunit, putative [KO:K12394]
Bm1_25725  Adaptin N terminal region family protein [KO:K12396]
Bm1_55840  Adaptin [KO:K12396]
Bm1_57425  Adaptin [KO:K12396]
Bm1_48425  Adaptin N terminal region family protein [KO:K12397]
Bm1_30830  Adaptin or adaptin-related protein protein 7 [KO:K12398]
Bm1_07400  adaptin or adaptin-related protein protein 8 [KO:K12399]
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Alberts B,  Johnson A, Lewis J, Raff M, Roberts K, Walter P
Molecular Biology of the Cell 4th ed.
Garland Science (2002)
Eskelinen EL, Tanaka Y, Saftig P
At the acidic edge: emerging functions for lysosomal membrane proteins.
Trends Cell Biol 13:137-45 (2003)
Neufeld EF
Lysosomal storage diseases.
Annu Rev Biochem 60:257-80 (1991)
von Figura K, Hasilik A
Lysosomal enzymes and their receptors.
Annu Rev Biochem 55:167-93 (1986)
Janvier K, Bonifacino JS
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Mol Biol Cell 16:4231-42 (2005)
Vergarajauregui S, Puertollano R
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
Autophagy 4:832-4 (2008)
KO pathway

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