KEGG   PATHWAY: bnc03440
Entry
bnc03440                    Pathway                                
Name
Homologous recombination - Bacillus cereus NC7401
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
bnc03440  Homologous recombination
bnc03440

Other DBs
GO: 0000724
Organism
Bacillus cereus NC7401 [GN:bnc]
Gene
BCN_4319  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
BCN_2121  single-stranded DNA-binding protein [KO:K03111]
BCN_5400  single-stranded DNA-binding protein [KO:K03111]
BCN_0004  DNA replication and repair protein RecF [KO:K03629]
BCN_4209  recombination protein O [KO:K03584]
BCN_0022  recombination protein RecR [KO:K06187]
BCN_3608  RecA protein [KO:K03553]
BCN_4487  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
BCN_4332  Holliday junction DNA helicase RuvA [KO:K03550]
BCN_4331  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
BCN_3684  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
BCN_4304  helicase, putative [KO:K03581] [EC:3.1.11.5]
BCN_4506  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
BCN_3646  DNA polymerase III, alpha subunit, Gram-positive type [KO:K03763] [EC:2.7.7.7]
BCN_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
BCN_2561  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
BCN_P062  DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
BCN_0020  DNA polymerase III, gamma and tau subunits [KO:K02343] [EC:2.7.7.7]
BCN_4236  conserved hypothetical protein [KO:K02340] [EC:2.7.7.7]
BCN_0028  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
BCN_3421  DNA polymerase III, epsilon subunit, putative [KO:K02342] [EC:2.7.7.7]
BCN_3697  primosomal protein N` [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG GENES (22)   
All databases (23)   

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