KEGG   PATHWAY: bpa03440Help
Entry
bpa03440                    Pathway                                

Name
Homologous recombination - Bordetella parapertussis 12822
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
bpa03440  Homologous recombination
bpa03440

Ortholog table
Module
bpa_M00260  DNA polymerase III complex, bacteria [PATH:bpa03440]
Other DBs
BSID: 13864
GO: 0000724
Organism
Bordetella parapertussis 12822 [GN:bpa]
Gene
BPP2048  recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
BPP0077  ssb; single-strand binding protein [KO:K03111]
BPP3293  hypothetical protein [KO:K03584]
BPP1223  recR; recombination protein RecR [KO:K06187]
BPP2633  recA; RecA protein [KO:K03553]
BPP1869  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
BPP3568  ruvA; holliday junction DNA helicase [KO:K03550] [EC:3.6.4.12]
BPP3571  ruvB; holliday junction DNA helicase [KO:K03551] [EC:3.6.4.12]
BPP3567  ruvC; crossover junction endodeoxyribonuclease [KO:K01159] [EC:3.1.22.4]
BPP2973  recG; ATP-dependent DNA helicase [KO:K03655] [EC:3.6.4.12]
BPP1707  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
BPP4400  dnaN; DNA polymerase iii, beta chain [KO:K02338] [EC:2.7.7.7]
BPP1221  dnaX; DNA polymerase III subunit Tau [KO:K02343] [EC:2.7.7.7]
BPP1729  holA; putative DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
BPP1560  holB; DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
BPP3831  dnaQ; DNA polymerase III, epsilon chain [KO:K02342] [EC:2.7.7.7]
BPP2401  putative exonuclease [KO:K02342] [EC:2.7.7.7]
BPP3286  conserved hypothetical protein [KO:K02339] [EC:2.7.7.7]
BPP4131  putative primosomal protein [KO:K04066] [EC:3.6.4.-]
BPP2467  priB; primosomal replication protein n [KO:K02686]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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