KEGG   PATHWAY: bpc03440
Entry
bpc03440                    Pathway                                
Name
Homologous recombination - Bordetella pertussis CS
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
bpc03440  Homologous recombination
bpc03440

Other DBs
GO: 0000724
Organism
Bordetella pertussis CS [GN:bpc]
Gene
BPTD_1097  recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
BPTD_3607  ssb; single-strand binding protein [KO:K03111]
BPTD_2387  hypothetical protein [KO:K03584]
BPTD_1534  recR; recombination protein RecR [KO:K06187]
BPTD_2506  recA; recombinase A [KO:K03553]
BPTD_1244  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
BPTD_3370  ruvA; Holliday junction DNA helicase RuvA [KO:K03550]
BPTD_3373  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
BPTD_3369  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.21.10]
BPTD_1594  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
BPTD_2291  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
BPTD_0502  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
BPTD_1532  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
BPTD_2010  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
BPTD_1825  holB; DNA polymerase III, delta subunit [KO:K02341] [EC:2.7.7.7]
BPTD_0421  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
BPTD_1992  putative exonuclease [KO:K02342] [EC:2.7.7.7]
BPTD_2379  hypothetical protein [KO:K02339] [EC:2.7.7.7]
BPTD_3249  putative primosomal protein [KO:K04066] [EC:5.6.2.4]
BPTD_2748  priB; primosomal replication protein N [KO:K02686]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG GENES (20)   
All databases (21)   

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